Healthcare-Associated Tubo-Ovarian Infections in Ukraine: Results of a Multicenter Study (2020-2022)

Abstract

The aim: To determine the current prevalence of healthcare-associated tubo-ovarian infections in female and antimicrobial resistance of the responsible pathogens in Ukraine. Materials and methods: We performed a retrospective multicenter cohort study was based on healthcare-associated infections surveillance data. Definitions of health¬care-associated tubo-ovarian infections were used from the CDC/ NHSN. The susceptibility to antibiotics was determined by disk diffusion method according to the EUCAST. Results: Among all the 1,528 of women in this study, the prevalence of healthcare-associated tubo-ovarian infections was 31.2%. Of these cases, Salpingitis, Oophoritis, and tubo-ovarian abscess were 47.5%, 34% and 18.5%, respectively. Of all cases tubo-ovarian infections in female, 74.7% were detected after hospital discharge. The predominant pathogens were: Escherichia coli (27.7%), Enterobacter spp. (12.2%), Klebsiella pneumoniae (9.6%), Staphylococcus aureus (8.2%), Pseudomonas aeruginosa (8.1%), and Enterococcus faecalis (7.5%), followed by Proteus mirabilis (5.1%), Streptococcus spp. (4.5%), Staphylococcus epidermidis (4.4%), and Acinetibacter spp. (4%). Methicillin-resistance was ob¬served in 16.8% of S. aureus (MRSA). No strains S.aureus and E. faecalis resistant to vancomycin. The overall proportion of extended spectrum beta-lactamases (ESBL) production among Enterobacteriaceae was 24.7%. The prevalence of ESBL production among E. coli isolates was 28.6% and among K. pneumoniae 12.8%. Resistance to third-generation cephalosporins was observed in 14.9% E.coli and 11.3% K. pneumoniae isolates. Carbapenem resistance was identified in 11.3% of P.aeruginosa isolates. Conclusions: A healthcare-associated tubo-ovarian infections of the female in Ukraine is a common occurrence and many cases are caused by pathogens that are resistant to antibiotics.

Deciphering the role of female reproductive tract microbiome in reproductive health: a review

“…Here, we focus on the effects of their interactions on the physiological functions of the reproductive tract. In general, the normal tissue structure of the vagina, cervix, uterus, and fallopian tubes provides a nutrient-rich habitat for the colonization and proliferation of tissue- (Chen et al, 2017;Onywera et al, 2019a;Onywera et al, 2019b;Łaniewski et al, 2018;Audirac-Chalifour et al, 2016;Carneiro et al, 2020;Gorgos et al, 2015;Lusk et al, 2016;Roy et al, 2021;Shroff, 2023;Wu et (Moreno et al, 2016;Franasiak et al, 2016;Verstraelen et al, 2016;Walther-Antońio et al, 2016;Chen W. et al, 2021;Kimura et al, 2019;Kitaya et al, 2018;Li et al, 2021;Liu et al, 2019;Medina-Bastidas et al, 2022;Moreno et al, 2018) Fallopian Burkholderia, Francisella, Treponema, Corynebacterium, Blautia, Escherichia, Trabulsiella (Miles et al, 2017;Zhou et al, 2019;Walther-Antońio et al, 2016;Banerjee et al, 2017;Salmanov et al, 2022b;Xie et al, 2017) BVAB, BV-associated bacteria; ↓, decrease.…”