Healthcare-associated infections: a threat to the survival of patients with COVID-19 in intensive care units

Macedo, Viviane de; Santos, Gabryella S P; Silva, R.N.; Couto, Clayton; Bastos, Camila; Viecelli, E.; Mateus, M.N.; Graf, Maria; Gonçalves, Raquel Bernardelli; Silva, M.A.; Bernardini, P; Boaventura, Viviane Pavanelo; Pereira, Helki Simone Rodrigues; Levin, Adeera

doi:10.1016/j.jhin.2022.05.013

Cited by 6 publications

(8 citation statements)

References 20 publications

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“…Enterobacter spp. Amikacin, ciprofloxacin, colistin, ertapenem, imipenem, meropenem, penicillin, sulfamethoxazoletrimethoprim Urinary tract infection, bloodstream infection [38,94,98] Previous studies have associated higher mortality in patients due to bacterial co-infections in influenza [100]. In addition, death cases of patients with COVID-19 along with bacterial co-infections have also been frequently reported [101].…”

Section: Excessive and Reckless Medical Prescription In The Covid-19 ...mentioning

confidence: 99%

Les misérables: a Parallel Between Antimicrobial Resistance and COVID-19 in Underdeveloped and Developing Countries

Jorge

Goes

Gontijo

2022

Curr Infect Dis Rep

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Purpose of Review The COVID-19 pandemic has been responsible for more than 6.3 million deaths worldwide. During the pandemic, the indiscriminate use of antibiotics has increased, contributing to the spread of multidrug-resistant bacteria. In this review, we aim to determine the spread and impact of antibiotic treatments in patients with COVID-19, focusing on underdeveloped and developing countries. Recent Findings Meta-analysis revealed that bacterial co-infections and secondary infections are relatively rare in COVID-19 patients, corresponding to less than 20% of hospitalized patients. Even so, most of these patients have received antibiotic treatments. Summary This review discusses how the COVID-19 pandemic could increase the emergence of multidrug-resistant strains to currently available antibiotics. Initially, we discussed the spread and impact of multidrug resistance of ESKAPE pathogens associated with nosocomial infections and analyzed their risk of secondary infections in patients with COVID-19. Then we highlight three factors related to the spread of resistant bacteria during the current pandemic: overprescription of antibiotics followed by self-medication. Finally, we discussed the lack of availability of diagnostic tests to discriminate the etiologic agent of a disease. All these factors lead to inappropriate use of antibiotics and, therefore, to an increase in the prevalence of resistance, which can have devastating consequences shortly. The data compiled in this study underscore the importance of epidemiological surveillance of hospital isolates to provide new strategies for preventing and controlling infections caused by multidrug-resistant bacteria. In addition, the bibliographic research also highlights the need for an improvement in antibiotic prescribing in the health system.

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Section: Excessive and Reckless Medical Prescription In The Covid-19 ...mentioning

confidence: 99%

Les misérables: a Parallel Between Antimicrobial Resistance and COVID-19 in Underdeveloped and Developing Countries

Jorge

Goes

Gontijo

2022

Curr Infect Dis Rep

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“…This is a nested case-control study in a cohort of 400 adult patients (≥ 18 years old) with COVID-19 hospitalized in the Intensive Care Units (ICU) of 4 hospitals in the city of Curitiba, Brazil: [8] 1- Santa Casa (a philanthropic hospital with 249 beds, with 48 ICU beds, which is a referral hospital for chest pain, and renal and heart transplantation); 2- Trabalhador Hospital (a state institution with 222 beds, including 40 ICU beds, that is a trauma referral hospital); 3- Rehabilitation Hospital (a state institution with 82 beds, including 62 ICU beds, which was adapted for COVID-19 patients only); and 4- Institute of Medicine (a private hospital, which was reopened by the city as a field hospital for COVID-19 patients, with 100 beds, including 60 ICU beds). The patients were admitted between 1 st March and 31 st December 2020.…”

Section: Methodsmentioning

confidence: 99%

“…Patients with severe disease were defined as patients with Oxygen Saturation (SpO 2 ) ≤94% in ambient air; or requiring supplemental oxygen; requiring mechanical ventilation; or requiring extracorporeal membrane oxygenation. [8] …”

Section: Methodsmentioning

confidence: 99%

“…The incidence of MDR-GNB infections in critically ill COVID-19 patients in different regions of the world ranges between 3.4% to 46%. 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 COVID-19 patients admitted to the ICU also seem to be more susceptible to colonization by MDR. [16] …”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that mainly critically ill patients with COVID-19 have secondary infections, 6 , 7 , 8 , 9 , 10 a proportion of them caused by Multidrug-Resistant (MDR) Gram-Negative Bacteria (GNB). The incidence of MDR-GNB infections in critically ill COVID-19 patients in different regions of the world ranges between 3.4% to 46%.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The health facility as a risk factor for multidrug-resistant gram-negative bacteria in critically ill patients with COVID-19

Macedo

Santos²,

Silva

et al. 2022

Clinics

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Impact of COVID-19 pandemic on the rates of central line...associated bloodstream infection and catheter-associated urinary tract infection in an.ßintensive care setting:.ßNational experience

Alsaffar

Alsheddi

Humayun

et al. 2023

American Journal of Infection Control

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Healthcare-associated infections: a threat to the survival of patients with COVID-19 in intensive care units

Cited by 6 publications

References 20 publications

Les misérables: a Parallel Between Antimicrobial Resistance and COVID-19 in Underdeveloped and Developing Countries

Les misérables: a Parallel Between Antimicrobial Resistance and COVID-19 in Underdeveloped and Developing Countries

The health facility as a risk factor for multidrug-resistant gram-negative bacteria in critically ill patients with COVID-19

Impact of COVID-19 pandemic on the rates of central line...associated bloodstream infection and catheter-associated urinary tract infection in an.ßintensive care setting:.ßNational experience

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