Health Utilities Associated with Hypoglycemic Events in Type 2 Diabetes Mellitus (T2DM) Patients Receiving Basal-Bolus Insulin Therapy

Ionova, Tatiana; Nikitina, Tatiana; Kurbatova, Kira A

doi:10.1016/j.jval.2015.09.2112

Cited by 2 publications

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“…After controlling for covariates, increasing severity of hypoglycaemia was inversely associated with mean health utility scores (0.64, 0.62 and 0.58 for no event, nonsevere and severe groups, respectively; P < .001; Figure ). Health utility scores were similar to those previously reported for patients with T2DM receiving basal‐bolus insulin therapy (0.68 for patients without hypoglycaemia, and 0.60 for those with severe hypoglycaemia) . The robustness of the regression model was confirmed by the consistent results of the sensitivity analysis (0.6371, 0.6212 and 0.5877 for no event, nonsevere and severe groups, respectively).…”

Section: Resultssupporting

confidence: 84%

Severity of hypoglycaemia and health‐related quality of life, work productivity and healthcare costs in patients with type 2 diabetes in Europe

Pawaskar

Witt

Engel

et al. 2018

Endocrino Diabet & Metabol

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SummaryAims: Hypoglycaemia in patients with type 2 diabetes mellitus (T2DM) is associated with poor health outcomes, such as reduced health-related quality of life (HRQoL).This study aimed to assess the impact of hypoglycaemic events by severity on HRQoL, work productivity and healthcare costs in patients with T2DM. Materials and Methods: European patients with T2DM selected from the NationalHealth and Wellness Survey who were currently receiving pharmacologic therapy were stratified into 3 groups based on the reported history and severity of hypoglycaemic events (no event, nonsevere, severe) experienced in the previous 3 months.Patients' work productivity, HRQoL, healthcare resource use (HCRU) and associated costs were assessed as self-reported outcomes. Results:Of 1269 patients included in the study, 652 (51.4%) patients had not experienced an event, while 533 (42.0%) and 84 (6.6%) patients had experienced nonsevere and severe hypoglycaemic events, respectively, in the previous 3 months. An increase in hypoglycaemia severity was associated with a decrease in HRQoL, and an increase in HCRU and healthcare costs. Conclusions:The impact of hypoglycaemia varies by severity and has a negative impact on HRQoL and overall HCRU and costs. K E Y W O R D Seconomic burden, healthcare resource use, health-related quality of life, hypoglycaemia, type 2 diabetes mellitus, work productivity

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Section: Resultssupporting

confidence: 84%

Severity of hypoglycaemia and health‐related quality of life, work productivity and healthcare costs in patients with type 2 diabetes in Europe

Pawaskar

Witt

Engel

et al. 2018

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

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Assessment of the Influence of Modified Risk Factors on the Occurrence of Complications in Patients With Diabetes Mellitus

Vodolagin

2021

Mediko-farmacevtičeskij žurnal "Pulʹs"

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One of the leading risk factors for the development of diabetes mellitus and its complications are overweight or obesity. The Russian Federation is in the category of 10 countries in the World with the highest prevalence of obesity. Therefore in Russia, according to the results of the ESSE-RF study, about a third of women (30.8%) and almost a quarter of men (23.2%) are obese. Overweight and obesity are also a risk of cardiovascular disease, kidney disease, liver disease and cancer. The total number of patients with diabetes mellitus according to the Federal Register of Diabetic Patients in Russia as of April 19, 2021 was 4.849 million people (3.3% of the population of the Russian Federation), including type 1 diabetes mellitus (DM1) - 5.4 % (267.0 thousand), type 2 diabetes mellitus (DM2) - 92.3% (4.48 million), other types of diabetes - 2.3% (101.4 thousand). According to a study of 434 patients with an established diagnosis of diabetes mellitus on the effect of being overweight on the risk of complications associated with diabetes mellitus, it was found that, as in the group with type 1 diabetes mellitus (RR = 1.664, 95% CI 1.07 –2.58) and in the group with type 2 diabetes mellitus (RR = 1.616, 95% CI 1.30–2.00), overweight was a statistically significant risk factor for complications. Evidence suggests the need to establish active implement for evaluation system for assessing the presence of various risk factors for the development of complications associated with diabetes mellitus and to change approaches in the prevention and treatment of diabetes.

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Health Utilities Associated with Hypoglycemic Events in Type 2 Diabetes Mellitus (T2DM) Patients Receiving Basal-Bolus Insulin Therapy

Cited by 2 publications

References 0 publications

Severity of hypoglycaemia and health‐related quality of life, work productivity and healthcare costs in patients with type 2 diabetes in Europe

Severity of hypoglycaemia and health‐related quality of life, work productivity and healthcare costs in patients with type 2 diabetes in Europe

Assessment of the Influence of Modified Risk Factors on the Occurrence of Complications in Patients With Diabetes Mellitus

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