“…6 In addition to ID, there are particular phenotypic characteristics of FXS that may be variably present, including prominent forehead, narrow face, protruding ears, high-arched palate, strabismus, macro-orchidism, and connective tissue dysplasia including hyperflexibility of the joints. 2,7,8 In clinical settings, patients with FXS may be seen for a variety of medical problems related to FXS including seizures, recurrent otitis media (OM), and gastrointestinal (GI) disturbances. It has been hypothesized that some of these, such as OM and gastroesophageal reflux (GER), may be related to connective tissue abnormalities.…”