Health risks and interventions in prediabetes: A review

Mahat, Roshan Kumar; Singh, Neelima; Arora, Manisha; Rathore, Vedika

doi:10.1016/j.dsx.2019.07.041

Cited by 30 publications

(24 citation statements)

References 122 publications

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“…In conformity with safety and quality standards, trained physicians performed blood withdrawals from antecubital vein by using a closed vacuum-extraction tube system. Concerning the fasting blood glucose, 100 mg/dL was chosen as the upper normal threshold according to the value ranges used by the American Diabetes Association in order to identify individuals with prediabetes (28).…”

Section: Methodsmentioning

confidence: 99%

Perceived Stress in a Gender Perspective: A Survey in a Population of Unemployed Subjects of Southern Italy

Costa

Briguglio

Mondello

et al. 2021

Front. Public Health

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Stressful life events, are differently handled by women and men. This study evaluates gender differences in perceived stress and health status among a sample of subjects going through a transition period from unemployment to work. This cross-sectional study enrolled 395 participants, 245 men (62%) and 150 (38%) women, between 19 and 67 years, that were going to be hired for a 6-month contract. Before being employed, all participants underwent a mandatory protocol consisting in a general medical check. Stress assessment was performed by using the Perceived Stress Scale (PSS). Most of the participants (68%) showed normal to low perceived stress level. But dividing the sample by gender, out of the remaining 32% with medium to high stress level, 11% male subjects and 22.7% females reported high perceived stress values. We found mean PSS values that are overlapping with those in the general population of developed countries. This study does not suggest an association between perceived stress and health or social parameters. However, our results highlight that the female gender is associated with higher stress level, pointing out the relevance of specific and designed interventions in the context of health promotion programs, especially in order to mitigate stress in more susceptible subjects.

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Section: Methodsmentioning

confidence: 99%

Perceived Stress in a Gender Perspective: A Survey in a Population of Unemployed Subjects of Southern Italy

Costa

Briguglio

Mondello

et al. 2021

Front. Public Health

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“…This may be due to the presence of comorbidities associated with elevated blood glucose levels. 14,15 Unfortunately, comorbidity data were not captured in the current study. Nevertheless, this remains an interesting finding from the current study that requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Blood glucose testing in the community: who are the users and do they have elevated blood glucose?

Reynolds

Mann

2020

J Prim Health Care

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INTRODUCTIONOn-the-spot blood glucose testing is a health service performed in public spaces to raise diabetes awareness and screen for elevated blood glucose levels. AIMTo describe the users of this service and the frequency of detecting elevated blood glucose. METHODSData collected at point-of-testing on a standardised form over 20 months in two regions of New Zealand were audited. Descriptive and simple inferential statistics report on population demographics and presence of elevated blood glucose (mmol/L). RESULTSData from 2156 individuals were audited. Most (1680, 78%) were female, the mean age was 52 years (standard deviation 18 years) and all major ethnic groups and socioeconomic quintiles were represented. For 53% of responders, this was their first blood glucose test. In total, 153 (7.1%) cases with elevated blood glucose were identified, including 94 who did not report a previous pre-diabetes or diabetes diagnosis. Blood glucose was not correlated with socioeconomic status (r=0.04; P=0.07), but weakly correlated with age (r=0.19; P<0.001). Blood glucose values did not appear to differ between ethnicities (P=0.052). Men had a higher mean value than women (P=0.003). People with elevated blood glucose access their general practitioner more often than people with normal blood glucose, irrespective of a diabetes diagnosis (P=0.002). DISCUSSIONOn-the-spot blood glucose testing is a health service accessed by a wide range of people, although more commonly by women than men. Future interventions targeting men may better engage them in health screening. Alongside awareness raising, on-the-spot community testing identified previously unknown elevated blood glucose levels at a rate of 1-in-22, and may lead to the earlier identification and treatment of prediabetes or diabetes.

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“…Insulin resistance is a risk factor in patients with hypertension that is closely associated with the activation of RAAS and SNS, resulting in increased peripheral vascular resistance and circulating plasma volume [59]. Therefore, the improvement of insulin resistance is important in the management of hypertension and its complications [60]. However, the specific roles of these signaling pathways in the mechanisms of GZD against hypertension need to be validated through rigorous investigations.…”

Section: Discussionmentioning

confidence: 99%

Potential mechanisms of Guizhi decoction against hypertension based on network pharmacology and Dahl salt-sensitive rat model

et al. 2021

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Background Guizhi decoction (GZD), a classical Chinese herbal formula, has been widely used to treat hypertension, but its underlying mechanisms remain elusive. The present study aimed to explore the potential mechanisms and therapeutic effects of GZD on hypertension by integrating network pharmacology and experimental validation. Methods The active ingredients and corresponding targets were collected from the Traditional Chinese Medicine Systems Pharmacology database and Analysis Platform (TCMSP). The targets related to hypertension were identified from the CTD, GeneCards, OMIM and Drugbank databases. Multiple networks were constructed to identify the key compounds, hub targets, and main biological processes and pathways of GZD against hypertension. The Surflex-Dock software was used to validate the binding affinity between key targets and their corresponding active compounds. The Dahl salt-sensitive rat model was used to evaluate the therapeutic effects of GZD against hypertension. Results A total of 112 active ingredients, 222 targets of GZD and 341 hypertension-related targets were obtained. Furthermore, 56 overlapping targets were identified, five of which were determined as the hub targets for experimental verification, including interleukin 6 (IL-6), C–C motif chemokine 2 (CCL2), IL-1β, matrix metalloproteinase 2 (MMP-2), and MMP-9. Pathway enrichment analysis results indicated that 56 overlapping targets were mainly enriched in several inflammation pathways such as the tumor necrosis factor (TNF) signaling pathway, Toll-like receptor (TLR) signaling pathway and nuclear factor kappa-B (NF-κB) signaling pathway. Molecular docking confirmed that most active compounds of GZD could bind tightly to the key targets. Experimental studies revealed that the administration of GZD improved blood pressure, reduced the area of cardiac fibrosis, and inhibited the expression of IL-6, CCL2, IL-1β, MMP-2 and MMP-9 in rats. Conclusion The potential mechanisms and therapeutic effects of GZD on hypertension may be attributed to the regulation of cardiac inflammation and fibrosis.

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Health risks and interventions in prediabetes: A review

Cited by 30 publications

References 122 publications

Perceived Stress in a Gender Perspective: A Survey in a Population of Unemployed Subjects of Southern Italy

Perceived Stress in a Gender Perspective: A Survey in a Population of Unemployed Subjects of Southern Italy

Blood glucose testing in the community: who are the users and do they have elevated blood glucose?

Potential mechanisms of Guizhi decoction against hypertension based on network pharmacology and Dahl salt-sensitive rat model

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