Health risk assessment of the intake of butyltin and phenyltin compounds from fish and seafood in Taiwanese population

Lee, Ching Chang; Hsu, Ya Chen; Kao, Yi Ting; Chen, Hsiu-Ling

doi:10.1016/j.chemosphere.2016.08.141

Cited by 29 publications

(16 citation statements)

References 46 publications

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“…drinking water, which is 2.3 L day −1 for an adult [22]; k p is the osmotic factor on the skin surface, which is 0.001 cm h −1 [68]; SA is the accessible skin surface area, which is 14,150 cm 2 for an adult [66]; F denotes the skin exposure time, which is 1 h [79]; A i (i = F, W, S) means the absorption factor of eating fish, drinking water, and skin absorption, which are 100% [37], 100% [22], and 1% [78], respectively; BW denotes the body weight (kg), which is 60 kg based on the average weight of Chinese.…”

Section: Health Risk Assessmentmentioning

confidence: 99%

“…These results indicate that TPhT contamination of aquatic products is a serious problem in the TGRR. The TARLs of TBT and TPhT in Taiwan were calculated by Lee et al [37]; these were 88.6 ng Sn g −1 and 149.4 ng Sn g −1 , respectively. The TARL of total butyltin (∑BTs = TBT + dibutyltin + monobutyltin) in seafood from Chinese Bohai coastal waters, calculated by Yang et al [75], was 90.8 ng Sn g −1 .…”

Section: Health Risks From Tbt and Tpht To The Population Of The Tgrrmentioning

confidence: 99%

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Fate simulation and risk assessment of TBT and TPhT considering water level fluctuations in the TGR before and after AFS Convention implementation in China

Gao

Chen

et al. 2020

Environ Sci Eur

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Background: The Three Gorges Reservoir (TGR) is the largest freshwater reservoir in China. Previous studies showed that organotin pollution is present in the TGR. In June 2011, the AFS Convention went into effect in China. In order to explore the pollution evolution processes of tributyltin (TBT) and triphenyltin (TPhT) before and after implementation of the AFS Convention and their variations with water level fluctuations in the TGR, the characteristic parameters of the TGR and the physicochemical parameters of TBT and TPhT were used to develop a level IV multimedia fugacity model considering water level fluctuations to simulate the fate, transfer, and transport of TBT and TPhT in the TGR. Based on the simulation results, exposure concentrations of TBT and TPhT were then used to assess the ecological and health risks in the TGR region (TGRR). Results:The simulation results showed that the average concentrations of both TBT and TPhT decreased in all compartments except the sediment, whereas the total content of the system continued to increase after the AFS Convention was implemented. The concentration of TBT in the sediment was higher than that in fish, while the concentration of TPhT in fish was much greater than that in the sediment. The total contents of both TBT and TPhT were highest in the sediment phase. In addition, variations in water level of the TGR significantly affected the distribution and transport of TBT and TPhT in the TGR. Conclusions:Sediment is an important source and sink of TBT and TPhT, and the water level regulation of the TGR strengthened the two roles of sediment. Both TBT and TPhT in surface water, but especially TBT, carried significant chronic exposure risks to the aquatic community of the TGR. Intake of TPhT, mainly through eating fish, posed a potential health risk to the population in the TGRR.

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Section: Health Risk Assessmentmentioning

confidence: 99%

Section: Health Risks From Tbt and Tpht To The Population Of The Tgrrmentioning

confidence: 99%

Fate simulation and risk assessment of TBT and TPhT considering water level fluctuations in the TGR before and after AFS Convention implementation in China

Gao

Chen

et al. 2020

Environ Sci Eur

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“…Here, cF and cW are the simulated concentrations in fish (ng/g) and in water 320 (ng/L), respectively; IRF is the average daily consumption of fish, which was calculated according to the annual consumption of fish and the population in the 322 TGRR, and the value of that is 59.84 g/d; TF represents the OTs purification 323 coefficient of the waterworks, which is 1 for both TBT and TPhT (Song et al, 2019;324 Streile et al, 1996); IRW denotes the average daily intake of drinking water, which is 325 2.3 L/d for an adult (Duan et al, 2011); kp is the osmotic factor on the skin surface, 326 which is 0.001 cm•h -1 (USEPA, 1992); SA is the accessible skin surface area, which is 14150 cm 2 for an adult (USEPA, 2011); F denotes the skin exposure time, which is 1h (Zatoń and Szczepan, 2012); Ai (i =F, W, S) means the absorption factor of eating fish, drinking water, and skin absorption, which are 100% (Lee et al, 2016), 100% (Duan et al, 2011), and 1% (Yu et al, 2012), respectively; BW denotes the body weight (kg), which is 60 kg based on the average weight of Chinese.…”

Section: Health Risk Assessmentmentioning

confidence: 99%

“…These results indicate that TPhT contamination of aquatic products is a serious problem in the TGRR. The TARLs of TBT and TPhT in Taiwan were calculated by Lee et al (2016); these were 491 88.6 ng Sn/g and 149.4 ng Sn/g, respectively. The TARL of total butyltin (∑BTs = TBT + dibutyltin + monobutyltin) in seafood from Chinese Bohai coastal waters, 493 calculated by Yang et al (2006), was 90.8 ng Sn/g.…”

Section: Ecological Risk Assessment Of Tbt and Tpht For Organisms In mentioning

confidence: 99%

Fate simulation and risk assessment of TBT and TPhT considering water level fluctuations in the TGR before and after AFS Convention implementation in China

Gao

Chen

et al. 2020

Preprint

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Background: The Three Gorges Reservoir (TGR) is the largest freshwater reservoir in China. Previous studies showed that organotin pollution is present in the TGR. In June 2011, the AFS Convention went into effect in China. In order to explore the pollution evolution processes of tributyltin (TBT) and triphenyltin (TPhT) before and after implementation of the AFS Convention and their variations with water level fluctuations in the TGR, the characteristic parameters of the TGR and the physicochemical parameters of TBT and TPhT were used to develop a level IV multimedia fugacity model considering water level fluctuations to simulate the fate, transfer, and transport of TBT and TPhT in the TGR. Based on the simulation results, exposure concentrations of TBT and TPhT were then used to assess the ecological and health risks in the TGR region (TGRR). Results: The simulation results showed that the average concentrations of both TBT and TPhT decreased in all compartments except the sediment, whereas the total content of the system continued to increase after the AFS Convention was implemented. The concentration of TBT in the sediment was higher than that in fish, while the concentration of TPhT in fish was much greater than that in the sediment. The total contents of both TBT and TPhT were highest in the sediment phase. In addition, variations in water level of the TGR significantly affected the distribution and transport of TBT and TPhT in the TGR.Conclusions: Sediment is an important source and sink of TBT and TPhT, and the water level regulation of the TGR strengthened the two roles of sediment. Both TBT and TPhT in surface water, but especially TBT, carried significant chronic exposure risks to the aquatic community of the TGR. Intake of TPhT, mainly through eating fish, posed a potential health risk to the population in the TGRR.

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“…OT’s deleterious effects upon wildlife and experimental animals are well documented and include endocrine disruption, immunotoxicity, neurotoxicity, genotoxicity, and metabolic dysfunction including obesity ( 2 , 4 ). Butyltins (BTs) and phenyltins, the major species of OTs, are widely used for agricultural purposes (insecticides, fungicides), in PVC industry, as industrial catalysts, and as additives on boat hull’s paints to avoid encrustations by barnacles, mussels, algae, and other aquatic invertebrates ( 1 – 3 , 5 , 6 ). Therefore, large quantities of OTs have been released into aquatic ecosystems, either directly as wastewater treatment plants or indirectly as hull’s residues, posing serious environmental risks to non-target species ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Organotins on Crustaceans: Update and Perspectives

2018

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Organotins (OTs) are considered some of the most toxic chemicals introduced into aquatic environments by anthropogenic activities. They are widely used for agricultural and industrial purposes and as antifouling additives on boat hull’s paints. Even though the use of OTs was banned in 2008, elevated levels of OTs can still be detected in aquatic environments. OTs’ deleterious effects upon wildlife and experimental animals are well documented and include endocrine disruption, immunotoxicity, neurotoxicity, genotoxicity, and metabolic dysfunction. Crustaceans are key members of zooplankton and benthic communities and have vital roles in food chains, so the endocrine-disrupting effects of tributyltin (TBT) on crustaceans can affect other organisms. TBT can disrupt carbohydrate and lipid homeostasis of crustaceans by interacting with retinoid X receptor (RXR) and crustacean hyperglycemic hormone (CHH) signaling. Moreover, it can also interact with other nuclear receptors, disrupting methyl farnesoate and ecdysteroid signaling, thereby altering growth and sexual maturity, respectively. This compound also interferes in cytochrome P450 system disrupting steroid synthesis and reproduction. Crustaceans are also important fisheries worldwide, and its consumption can pose risks to human health. However, some questions remain unanswered. This mini review aims to update information about the effects of OTs on the metabolism, growth, and reproduction of crustaceans; to compare with known effects in mammals; and to point aspects that still needs to be addressed in future studies. Since both macrocrustaceans and microcrustaceans are good models to study the effects of sublethal TBT contamination, novel studies should be developed using multibiomarkers and omics technology.

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Health risk assessment of the intake of butyltin and phenyltin compounds from fish and seafood in Taiwanese population

Cited by 29 publications

References 46 publications

Fate simulation and risk assessment of TBT and TPhT considering water level fluctuations in the TGR before and after AFS Convention implementation in China

Fate simulation and risk assessment of TBT and TPhT considering water level fluctuations in the TGR before and after AFS Convention implementation in China

Fate simulation and risk assessment of TBT and TPhT considering water level fluctuations in the TGR before and after AFS Convention implementation in China

Effects of Organotins on Crustaceans: Update and Perspectives

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