Health-resource utilization attributable to skeletal-related events in patients with advanced cancers associated with bone metastases: results of the US cohort from a multicenter observational study

Mahmood, Aftab; Ghazal, Hassan; Fink, M.; Patel, Mehool; Atchison, C.; Wei, Rachel; Suenaert, Peter; Pinzone, Joseph J.; Slasor, Peter; Chung, Karen

doi:10.1016/j.cmonc.2012.02.015

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…As previously reported (Mahmood et al . ), few emergency room, nursing home/long‐term care facility, and home health visits were reported in this study, which we believe to be due to underreporting as these items may not have been recorded or available in the patient medical records used in this study. Information on use of pain medications was not collected in this study; therefore, this additional measurement of burden of HRU could not be assessed.…”

Section: Discussionmentioning

confidence: 84%

“…We previously reported the relative burden of each of the SRE types in the overall study population and in each solid tumour type (breast, lung and prostate) in the US (Mahmood et al . ) and in individual European countries including the UK, Spain, Germany and Italy (Hoefeler et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…Nursing home/long‐term care facility stays and home health visits were also collected in the study but are not reported in the present analysis; they were previously reported for the US study population (Mahmood et al . ). Patient‐reported outcome (PRO) data measuring HRQoL using the validated questionnaire, EuroQol‐5D (EQ‐5D) (The EuroQol Group, ; EuroQol, http://www.euroqol.org), were to be collected at enrolment and following a SRE throughout the data collection period (approximately 7, 30, 60 and 90 days following a SRE).…”

Section: Methodsmentioning

confidence: 97%

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Health resource utilisation associated with skeletal-related events in patients with bone metastases secondary to solid tumours: regional comparisons in an observational study

Durán

Fink

Bahl³

et al. 2016

Eur J Cancer Care

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Skeletal-related events (SREs) including spinal cord compression, pathologic fracture, and radiation or surgery to bone, occur frequently due to bone metastases in advanced cancer. This analysis of a multicentre, observational study was designed to describe cross-regional differences in health resource utilisation (HRU) of SREs in Western Europe and the US. Patients with bone metastases due to breast, lung or prostate cancer, or multiple myeloma who had experienced a SRE within the past 97 days were enrolled. Investigators recorded HRU associated with SREs, including hospitalisation and length of stay (LOS), outpatient visits, procedures and bisphosphonate use. This subanalysis includes 668 patients with solid tumours (US, n = 190 with 354 SREs; EU, n = 478 with 893 SREs). The rate of SREs associated with hospitalisation(s) was higher in the EU vs. the US (30% vs. 15%, P < 0.001) and LOS was longer in the EU [mean (SD) days/SRE: 19.87 (17.31) vs. 10.61 (9.39)]. However, the US was associated with higher rate of SREs with outpatient visits than the EU (88% vs. 74%, P < 0.0001) and more procedures [mean (SD)/SRE: 11.26 (7.94) vs. 6.91 (6.48)]. Bisphosphonates were less often used in the EU (65% vs. 76% of US, P = 0.0033). In patients experiencing SREs due to bone metastases, HRU patterns reflect regional diversity with a substantial burden in both regions.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 97%

See 1 more Smart Citation

Health resource utilisation associated with skeletal-related events in patients with bone metastases secondary to solid tumours: regional comparisons in an observational study

Durán

Fink

Bahl³

et al. 2016

Eur J Cancer Care

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“…In Portugal, a limited retrospective chart review of patients with breast cancer ( n = 121) or prostate cancer ( n = 31) and at least one SRE occurring within 12 months reported high costs associated with SREs; these costs were predominantly due to hospitalization and medication [ 8 ]. In the USA, a prospective study of 238 patients reported substantial HRU associated with SREs, with considerable numbers and durations of inpatient stays, numbers of outpatient visits, and numbers of procedures [ 9 ]. The same was concluded from the European cohort of the same study (conducted in Germany, Italy, Spain, and the UK; n = 631) in which all SREs were associated with considerable HRU burden and costs [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Health resource utilization associated with skeletal-related events: results from a retrospective European study

et al. 2015

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BackgroundBone complications, also known as skeletal-related events (SREs), are common in patients with bone metastases secondary to advanced cancers.ObjectiveTo provide a detailed estimate of the health resource utilization (HRU) burden associated with SREs across eight European countries.MethodsEligible patients from centers in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden, and Switzerland with bone metastases or lesions secondary to breast cancer, prostate, or lung cancer or multiple myeloma who had experienced at least one SRE (defined as radiation to bone, long-bone pathologic fracture, other bone pathologic fracture, surgery to bone or spinal cord compression) were entered into this study. HRU data were extracted retrospectively from the patients’ charts from 3.5 months before the index SRE until 3 months after the index SRE (defined as an SRE preceded by an SRE-free period of at least 6.5 months).ResultsOverall, the mean number of inpatient stays per SRE increased from baseline by approximately 0.5–1.5 stays, with increases in the total duration of inpatient stays of approximately 6–37 days per event. All SREs were associated with substantial increases from baseline in the frequency of procedures and the number of outpatient and day-care visits.ConclusionsSREs are associated with substantial HRU owing to considerable increases in the number and duration of inpatient stays, and in the number of procedures, outpatient visits, and day-care visits. These data collectively provide a valuable summary of the real-world SRE burden on European healthcare systems.

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“…5 Available evidence, mainly from Europe and the United States, reveals that MBD and SREs substantially increase healthcare resource utilization (HCRU) and healthcare costs in cancer patients. [6][7][8][9][10][11][12][13][14][15] The cost burden due to MBD among PC patients in the United States was estimated at US$1.9 billion in 2004. 13 However, few studies have evaluated the HCRU and costs associated with MBD in Canada, and none have done so comprehensively for the PC population.…”

Section: Introductionmentioning

confidence: 99%

Burden of illness of bone metastases in prostate cancer patients in Québec, Canada: A population-based analysis

Perrault¹,

Fradet²,

Lauzon³

et al. 2015

CUAJ

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Introduction: Metastasis of prostate cancer (PC) to bone (metastatic bone disease, MBD) increases morbidity, but Canadian data are lacking on the associated healthcare resource utilization (HCRU) and costs. We quantified MBD-related HCRU and associated costs in this population, and assessed skeletal-related events (SREs), such as pathologic fracture, spinal cord compression, bone radiotherapy, and bone surgery. Methods: We conducted a retrospective, population-based cohort study using the Québec health insurance agency database. Prescription drug and medical services data were retrieved for patients with ≥1 healthcare claim in 2001 with a PC diagnosis (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code of 185.xx). Patients with ≥2 MBDrelated claims or an SRE were compared with a matched-control group of PC patients without MBD. Patients were followed until death, loss to follow-up, or the end of available data (August 31, 2010). Costs (in 2012 Canadian dollars) were adjusted for age, year of MBD diagnosis, general health status, and baseline resource utilization. Results: Compared with controls (n = 1671), MBD patients (n = 626) had significantly higher HCRU. Adjusted mean (95% confidence interval) all-cause healthcare costs were $11 820 (7248-16 058) higher, and MBD-related costs were $3 091 (1267-4861) higher in MBD patients than in controls. Nearly 50% of MBD patients received radiotherapy within 2.5 years of their MBD diagnosis, but most exited the study without experiencing other SREs. Conclusion: MBD imposes a heavy HCRU and cost burden among patients with PC in Canada. Effective therapy is needed to reduce the clinical and economic impact of MBD in this population.

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Health-resource utilization attributable to skeletal-related events in patients with advanced cancers associated with bone metastases: results of the US cohort from a multicenter observational study

Cited by 8 publications

References 24 publications

Health resource utilisation associated with skeletal-related events in patients with bone metastases secondary to solid tumours: regional comparisons in an observational study

Health resource utilisation associated with skeletal-related events in patients with bone metastases secondary to solid tumours: regional comparisons in an observational study

Health resource utilization associated with skeletal-related events: results from a retrospective European study

Burden of illness of bone metastases in prostate cancer patients in Québec, Canada: A population-based analysis

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