Health-related quality of well-being in chronically hospitalized patients with schizophrenia: comparison with matched outpatients

Kasckow, John; Twamley, Elizabeth W.; Mulchahey, J.J.; Carroll, Brendan T.; Sabai, Mya; Strakowski, Stephen M.; Patterson, Thomas L.; Jeste, Dilip V.

doi:10.1016/s0165-1781(01)00260-8

Cited by 73 publications

(40 citation statements)

References 15 publications

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“…These results add to the literature on outcome assessment in schizophrenia and suggest that the predictors of QOL (mainly negative and depressive symptoms) are different from the predictors of everyday functioning and community integration (i.e., cognition and psychiatric symptoms; Green et al, 1996;Twamley et al, 2002). The current results also echo previous findings from our research group regarding the relationship between QOL and depressive and negative symptoms using a health-related quality of well-being measure that combines subjective and objective QOL items (Kasckow et al, 2001;Mittal et al, 2006;Patterson et al, 1997).…”

Section: Discussionsupporting

confidence: 84%

Subjective and objective quality of life in schizophrenia

Narvaez¹,

Twamley²,

McKibbin³

et al. 2008

Schizophrenia Research

224

139

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Objective-Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually defined as participation in activities and relationships). We examined separately the clinical, functional, and cognitive predictors of subjective and objective QOL in outpatients with schizophrenia. We hypothesized that better subjective QOL would be associated with less severe negative and depressive symptoms, better objective QOL, and greater everyday functioning capacity, and that better objective QOL would be associated with less severe negative and depressive symptoms, better cognitive performance, and greater functional capacity.Method-Participants included 88 outpatients with schizophrenia or schizoaffective disorder who completed a comprehensive series of assessments, including measures of positive, negative, and depressive symptoms; performance-based functional skills; a neuropsychological battery; and an interview measure of subjective and objective QOL.Results-In the context of multiple predictor variables, more severe depressive symptoms and better neuropsychological functioning were independent predictors of worse subjective QOL. More severe negative symptoms predicted worse objective QOL. Functional capacity variables were not associated with subjective or objective QOL.Conclusion-Treatments to improve QOL in schizophrenia should focus on negative symptoms and depressive symptoms.

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Section: Discussionsupporting

confidence: 84%

Subjective and objective quality of life in schizophrenia

Narvaez¹,

Twamley²,

McKibbin³

et al. 2008

Schizophrenia Research

224

139

View full text Add to dashboard Cite

show abstract

“…Patients living in highly institutionalised settings showed a significant decrease in their subjective assessments within the 2-year period, even when the sociolegal criterion of stability was taken into account. This finding adds to those of studies using this outcome domain within the framework of de-institutionalisation of (mostly schizophrenic) patients to various new forms of community based supported housing that have shown that only patients able to integrate themselves into housing facilities characterised by a higher level of demands of autonomous behaviour improve their subjective quality of life (Bunt and Hansson 2004;Franz et al 2002;Hanrahan et al 2001;Hoffmann 2003;Horan et al 2001;Kasckow et al 2001). Furthermore, this underscores previous results that have called attention to the social integration lacking in patients who live in institutionalised settings, such as homes or hostels, as assessed in this study (Borge et al 1999;Leisse and Kallert 2000).…”

Section: Discussionsupporting

confidence: 52%

Comparing the effectiveness of different types of supported housing for patients with chronic schizophrenia

2006

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Upward trend in tobacco use, particularly in women, is a reason for concern. In medical faculties, principles of prevention should be more emphasized and the students motivated for healthy life-style and to fulfill their future role in public health. The situation noted among medical students indicates that a community in Slovakia is still not satisfactory inclined towards non-smoking and a dramatic decrease of tobacco use can hardly be expected either in the near future.

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“…In our previous studies, we (Kasckow et al, 2001) demonstrated similar low levels of quality of life in a cohort of patients with similar HAMD 17 item scores. In these patients, both cognitive status and psychopathology predicted decreased quality of life over 6 months.…”

Section: Discussionmentioning

confidence: 52%