Health-Related Quality of Life, Work Productivity, and Daily Activity Among A Sample of Commercially Insured Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation In The United States

Cai, Qing; Buono, JL; Spalding, WM; Stephenson, JJ; Tan, Hiangkiat; Carson, RT; Doshi, JA

doi:10.1016/j.jval.2015.09.2229

Cited by 5 publications

(3 citation statements)

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“…This study contributes uniquely to the large body of research on the effect of IBS on overall quality of life by elucidating the specific behavioral impact of IBS on daily living. Existing quality of life research suggests that IBS is perceived to be as debilitating as the flu 9 and that reported QoL is lower in IBS when compared to gastroesophageal reflux disease, inflammatory bowel diseases, diabetes, and end-stage renal disease 25,26 . Although reasons for such low QoL in IBS have not been clearly identified, it is apparent that the impact of IBS on a patient’s daily life should not be underestimated 27 .…”

Section: Discussionmentioning

confidence: 99%

The impact of irritable bowel syndrome on daily functioning: Characterizing and understanding daily consequences of IBS

Ballou

Keefer

2016

Neurogastroenterology Motil

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Background Despite the well-documented economic and psychosocial burden of Irritable Bowel Syndrome (IBS), few studies have focused on the impact of IBS on daily activities. The current study aims to quantify impairment in daily activities among IBS patients and to evaluate the relationship between impairment, IBS, quality of life, and psychiatric symptoms. Methods 179 participants meeting ROME-III criteria for IBS completed an online research survey evaluating the following variables: 1) the impact of IBS on daily activities, 2) comorbid psychiatric diagnoses, 3) symptom severity, 4) quality of life, and 5) and symptom-specific cognitive affective factors related to IBS. Key Results This sample reported a high degree of impairment due to IBS, with 76% of the sample reporting some degree of IBS-related impairment in at least 5 different domains of daily life. Rates of impairment were significantly higher for participants who met criteria for anxiety, depression, and/or panic disorder. Conclusions and inferences This study contributes to existing literature by demonstrating a high level of daily impairment among patients with Irritable Bowel Syndrome, particularly those who meet criteria for anxiety, depression, and panic disorder. These findings support the importance of integrated psychosocial and medical care for IBS patients, and highlight the utility of evaluation and intervention for behavioral avoidance/impairment especially among those who exhibit signs or symptoms of psychiatric diagnoses.

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Section: Discussionmentioning

confidence: 99%

The impact of irritable bowel syndrome on daily functioning: Characterizing and understanding daily consequences of IBS

Ballou

Keefer

2016

Neurogastroenterology Motil

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“…IBS is increasingly being referred to as a disorder of gut-brain interaction to highlight the role of the gut-brain (i.e., mind-body) axis in symptom generation. IBS is characterized by abdominal pain and altered bowel habits (constipation and/or diarrhea), and it is associated with a significant reduction in quality of life, high health care utilization, and comorbidities with other chronic conditions (2)(3)(4). Treatment options for IBS typically include medical therapy, dietary, and life-style interventions as well as mind-body therapies, and the condition is best managed when approached from a biopsychosocial perspective (5).…”

Section: Introductionmentioning

confidence: 99%

Psychological Predictors of Response to Open-Label Versus Double-Blind Placebo in a Randomized Controlled Trial in Irritable Bowel Syndrome

et al. 2022

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ObjectiveThere is growing evidence that open-label placebo (OLP) may be an efficacious treatment of chronic and functional conditions. However, patient-level predictors of response to OLP have not been clearly identified. The aim of this study is to evaluate the psychological predictors of response to OLP and to compare this to double-blind placebo (DBP) and no-pill control (NPC).MethodsThis study is a secondary analysis of data collected in a 6-week randomized controlled trial evaluating placebo effects in irritable bowel syndrome (IBS). The primary outcome was change in IBS severity. Hierarchical linear regression identified predictors of placebo response in general and compared them between those randomized to OLP, DBP, and NPC. Predictor variables included personality traits, generalized anxiety, depression, visceral sensitivity (a measure of symptom-specific anxiety), and pain catastrophizing.ResultsA total of 210 participants (mean age = 42.3 years, 73.3% female) were included. Regression models revealed that visceral sensitivity was a predictor of response to OLP and NPC but not DBP. Interestingly, the effects were opposite, with high visceral sensitivity predicting less improvement in NPC and more improvement in OLP. Pain catastrophizing was a negative predictor of response to OLP (i.e., high pain catastrophizing was associated with less improvement in OLP). Neither visceral sensitivity nor pain catastrophizing played a significant role for response to DBP.ConclusionsIBS participants who score low on the Pain Catastrophizing Scale but high on the Visceral Sensitivity Index seem to benefit particularly from OLP. Our study suggests that different psychological mechanisms may be involved in DBP and OLP interventions.

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“…Its diagnosis is based on patient‐reported symptoms such as infrequent stools, hard/lumpy stool consistency, straining, and incomplete evacuation 2 . Chronic constipation impacts daily activities and adversely affects quality of life 3,4 . Furthermore, it is responsible for substantial health care costs, ranging from $1912 to $11,991 per patient annually 5,6 …”

Section: Introductionmentioning

confidence: 99%

The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta‐analysis of randomized controlled trials

Schoot

Creedon

Whelan

et al. 2023

Neurogastroenterology Motil

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BackgroundOver‐the‐counter supplements are commonly used to manage chronic constipation; however, their efficacy remains unclear. We aimed to investigate the effect of food, vitamin or mineral supplements on stool output, gut transit time, symptoms, and quality of life in adults with chronic constipation via a systematic review and meta‐analysis of randomized controlled trials (RCTs).MethodsStudies were identified using electronic databases, backward citation, and hand‐searching abstracts. RCTs reporting administration of food supplements (e.g., fruit extract supplements), vitamin or mineral supplements in adults with chronic constipation were included. Studies administering whole foods (e.g., fruits) were excluded. Risk of bias (RoB) was assessed with Cochrane RoB 2.0. Relative risks (RR), mean differences (MD), or standardized mean differences (95% confidence intervals [CI]) were calculated using a random‐effects model.Key ResultsEight RCTs (787 participants) were included, investigating kiwifruit (n = 3 RCTs), senna (n = 2), magnesium oxide (n = 2), Ziziphus jujuba (n = 1), and Malva Sylvestris (n = 1) supplements. Kiwifruit supplements did not impact stool frequency (MD 0.24 bowel movements/week [−0.32, 0.80]; p = 0.40) or consistency (MD −0.11 Bristol points [−0.31, 0.09], p = 0.29). Overall, 61% responded to senna and 28% to control; however, this did not reach statistical significance (RR 2.78, [0.93, 8.27]; p = 0.07). Overall, 68% responded to magnesium oxide and 19% to control (RR 3.32 [1.59, 6.92]; p = 0.001). Magnesium oxide improved stool frequency (MD 3.72 bowel movements/week [1.41, 6.03]; p = 0.002) and consistency (MD 1.14 Bristol points [0.48, 1.79]; p = 0.0007).Conclusions and InferencesMagnesium oxide supplements are effective at improving cardinal symptoms of chronic constipation. Senna and kiwifruit supplements did not impact symptoms; however, findings were based on a small number of studies. Further research is required to investigate the effect of food supplements (e.g., kiwifruit supplements), as well as their whole food equivalents (e.g., whole kiwifruits) in chronic constipation.

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Health-Related Quality of Life, Work Productivity, and Daily Activity Among A Sample of Commercially Insured Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation In The United States

Cited by 5 publications

References 0 publications

The impact of irritable bowel syndrome on daily functioning: Characterizing and understanding daily consequences of IBS

The impact of irritable bowel syndrome on daily functioning: Characterizing and understanding daily consequences of IBS

Psychological Predictors of Response to Open-Label Versus Double-Blind Placebo in a Randomized Controlled Trial in Irritable Bowel Syndrome

The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta‐analysis of randomized controlled trials

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