Health-related quality of life using QOLIE-31: Before and after epilepsy surgery a prospective study at a tertiary care center

Ahmad, Faiz U.; Tripathi, Manjari; Maruvada, Padma; Gaikwad, Shailesh; Gupta, Aditya; Bal, Chandrasekhar; Sarkar, Chitra; Gupta, Smriti; Wadhawan, Ashima Nehra; Sharma, Bhavani Shankar; Chandra, P. Sarat

doi:10.4103/0028-3886.37093

Cited by 17 publications

(6 citation statements)

References 25 publications

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“…Earlier studies conducted on PWE in India using QOLIE-31 showed mean total QOL score ranging from 38.4 to 68. [ 19 20 21 22 23 ] In our study, mean total QOL score was 60.29 which was within the range of scores observed earlier and indicate good total QOL score. Various studies showed high and least scores in various subscales of QOLIE-31 such as highest in cognitive functioning and least score in energy fatigue;[ 19 ] highest in emotional well-being and least score in seizure worry;[ 20 ] highest in energy/fatigue and least score in overall QOL;[ 22 ] and highest in medication effects and least score in seizure worry.…”

Section: Discussionsupporting

confidence: 87%

“…Greater the score, better the QOL. QOL in epilepsy-31 (QOLIE-31) questionnaire has been validated in Marathi-,[ 19 20 ] Malayalam-,[ 21 ] Hindi-,[ 22 23 ] and Kannada-[ 24 ] speaking populations of India. Cronbach's alpha and intraclass correlation coefficient obtained for QOLIE-31 in the present study were 0.946 and 0.974, respectively, which indicated good internal consistency and reproducibility of the instrument for assessment of QOL for the population of the present study.…”

Section: S Ubjects and M Ethodsmentioning

confidence: 99%

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Stigma and polytherapy: Predictors of quality of life in patients with epilepsy from South India

Nagarathnam

Vengamma

Shalini

et al. 2017

Ann Indian Acad Neurol

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Section: Discussionsupporting

confidence: 87%

Section: S Ubjects and M Ethodsmentioning

confidence: 99%

Stigma and polytherapy: Predictors of quality of life in patients with epilepsy from South India

Nagarathnam

Vengamma

Shalini

et al. 2017

Ann Indian Acad Neurol

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“…Only a single QOL domain correlated with absolute seizure frequency, overall QOL, but two domains including overall QOL and social function, along with overall score correlated with perceived change in seizure frequency. Like previous studies,6,7,13,14 in our study more QOL domains correlated with perceived change in frequency rather than absolute seizure frequency. Therefore, we speculate that QOL has determinants other than epilepsy-related variables, which we did not measure in this study.…”

Section: Discussionsupporting

confidence: 85%

Quality of Life and Its Determinants in Adult Drug Refractory Epilepsy Patients Who Were Not Candidates for Epilepsy Surgery: A Correlational Study

Puri¹,

Dash²,

Padma³

et al. 2018

J Epilepsy Res

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Background and Purpose This study was performed to elucidate quality of life (QOL) and its determinants in adult drug refractory epilepsy (DRE) patients who were not candidates for epilepsy surgery. Methods A correlational study was performed at the center of excellence, epilepsy between July 2014 to June 2016. All consecutive DRE patients who were not candidates for epilepsy surgery were enrolled. The outcomes were QOL, assessed using the quality of life inventory in epilepsy-31 items (QOLIE-31) inventory and the correlation of QOL with epilepsy-related variables like seizure severity and frequency. We also compared current QOL with QOL during the pre-surgical evaluation to strengthen our study outcome. Results A total of 129 adult patients were enrolled over two years. The mean age was 26.5 ± 6.7 years and male: female ratio was 3: 1. The mean age at epilepsy onset was 9.6 ± 6.6 years and mean duration of epilepsy was 14.9 ± 7.5 years. There was lower seizure frequency than during pre-surgical evaluation in 37.2% of patients, while in 62.8% the seizure frequency remained the same or was higher. Nine (6.98%) patients became seizure free. In comparison to QOL status during the pre-surgical evaluation, there was statistically significant worsening of QOL in all domains ( p < 0.01). Seizure severity significantly correlated with almost all QOL domains ( p ≤ 0.01), while seizure frequency significantly correlated with only the single domain of overall QOL ( p = 0.03). Conclusions The QOL of DRE patients who were not candidates for epilepsy surgery worsened relative to the QOL during the pre-surgical evaluation period. Seizure severity significantly correlated with QOL, but seizure frequency did not.

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“…[141821] Psychiatric outcome and neuropsychologic and psychosocial function after surgery usually improves, with worsening related predominantly to the persistence of seizures. Employment status and activities of daily living in general improve, mortality is decreased and medication regimens are reduced about 1 year after surgery gradually.…”

Section: Investigations For Epilepsy Surgerymentioning

confidence: 99%

“…Employment status and activities of daily living in general improve, mortality is decreased and medication regimens are reduced about 1 year after surgery gradually. [18] Stopping the drugs is to be done only in select cases as chance of recurrence is dependent on several factors. Hence the patient usually remains on a moderate dose of at least one drug 2-3 years after surgery, this decision should be taken only at a trained centre preferably by the epileptologist.…”

Section: Investigations For Epilepsy Surgerymentioning

confidence: 99%

Epilepsy surgery: Recommendations for India

Chandra

Tripathi

2010

Ann Indian Acad Neurol

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The following article recommends guidelines for epilepsy surgery for India. This article reviews the indications, the various surgical options available and the outcome of surgery for drug resistant epilepsy based on current evidence. Epilepsy surgery is a well-established option for patients who have been diagnosed to have drug resistant epilepsy (DRE) (on at least two appropriate, adequate anti-epileptic drugs (AEDs) (either in monotherapy or in combination) with continuing seizures), where the presurgical work-up has shown concordance of structural imaging (magnetic resonance imaging) and electrical mapping data (electroencephalography (EEG), video EEG). There may be a requirement of functional imaging techniques in a certain number of DRE like positron emission tomography (PET), single photon emission tomography, (SPECT)). Invasive monitoring should be restricted to a few when all noninvasive investigations are inconclusive, there is a dual pathology or there is a discordance of noninvasive data. The types of surgery could be curative (resective surgeries: amygdalo hippocampectomy, lesionectomy and multilobar resections; functional surgeries: hemispherotomy) and palliative (multiple subpial transaction, corpus callosotomy, vagal nerve stimulation). Epilepsy surgery in indicated cases has a success range from 50 to 86% in achieving seizure freedom as compared with <5% success rate with AEDs only in persons with DRE. Centers performing surgery should be categorized into Level I and Level II.

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Health-related quality of life using QOLIE-31: Before and after epilepsy surgery a prospective study at a tertiary care center

Cited by 17 publications

References 25 publications

Stigma and polytherapy: Predictors of quality of life in patients with epilepsy from South India

Stigma and polytherapy: Predictors of quality of life in patients with epilepsy from South India

Quality of Life and Its Determinants in Adult Drug Refractory Epilepsy Patients Who Were Not Candidates for Epilepsy Surgery: A Correlational Study

Epilepsy surgery: Recommendations for India

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