Health-Related Quality of Life Results in Pathologic Stage C Prostate Cancer From a Southwest Oncology Group Trial Comparing Radical Prostatectomy Alone With Radical Prostatectomy Plus Radiation Therapy

Moinpour, Carol M.; Hayden, Katherine; Unger, Joseph M.; Thompson, Ian M.; Redman, Mary W.; Canby-Hagino, Edith; Higgins, Betsy; Sullivan, Jeremy A.; Lemmon, Dianne; Breslin, Sheila; Crawford, E. David

doi:10.1200/jco.2006.10.4505

Cited by 133 publications

(89 citation statements)

References 37 publications

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“…Some studies have reported that RT after RP has minimal long-term urinary consequences. 11 In contrast, other studies have reported a higher morbidity of subsequent RT after RP. The EORTC trial 22911 showed 11% more UAEs (any grade) at 10 years follow-up, in men with RP + RT, compared to RP alone 12 .…”

Section: Accepted Manuscriptcontrasting

confidence: 42%

Urinary Diversion for Severe Urinary Adverse Events of Prostate Radiation: Results from a Multi-Institutional Study

et al. 2017

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Section: Accepted Manuscriptcontrasting

confidence: 42%

Urinary Diversion for Severe Urinary Adverse Events of Prostate Radiation: Results from a Multi-Institutional Study

et al. 2017

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“…Therefore, these results may not be applicable to current clinical practice. 30 Moinpour et al 31 reported on prospective assessments of the QOL outcomes for the SWOG 8794 randomized adjuvant radiation therapy trial. In their report on 217 patients, who completed a HealthRelated Quality-of-Life (HRQOL) questionnaire after surgery and before radiation therapy, the researchers found no difference in erectile functioning between 107 patients who underwent radical prostatectomy alone and those who had additional radiation therapy.…”

Section: Resultsmentioning

confidence: 99%

Counseling patients about sexual health when considering post-prostatectomy radiation treatment

et al. 2009

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Prostate cancer is the second most frequently diagnosed cancer in men in the United States. Many men with clinically localized prostate cancer survive for 15 years or more. Although early detection and successful definitive treatments are increasingly common, a debate regarding how aggressively to treat prostate cancer is ongoing because of the effect of aggressive treatment on the quality of life, including sexual functioning. We examined current research on the effect of post-prostatectomy radiation treatment on sexual functioning, and suggest a way in which patient desired outcomes might be taken into consideration while making decisions with regard to the timing of radiation therapy after prostatectomy.

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“…Previous studies have more thoroughly addressed the HRQOL effects of adjuvant EBRT following RP. 19 With regard to HRQOL assessments, the UCLA PCI is relatively insensitive to urinary irritative symptoms often seen after radiotherapy and does not assess hormonal symptoms. 21 Other HRQOL surveys, such as the EPIC, may have provided more information, but in terms of sexual and urinary domains the EPIC and the UCLA PCI have been shown to correlate well.…”

Section: Discussionmentioning

confidence: 99%

Health Related Quality of Life in Patients Treated With Multimodal Therapy for Prostate Cancer

Wu¹,

Cooperberg²,

Sadetsky³

et al. 2008

Journal of Urology

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Purpose: Patients with prostate cancer and high risk disease characteristics may benefit from multimodal therapy. However, the effects of multimodal therapy on health related quality of life have not been comprehensively described. We further characterized health related quality of life in patients treated with multimodal therapy. Materials and Methods: Patient data were obtained from the CaPSURE™ database, a national disease registry of men with prostate cancer. Included patients received active primary therapy (ie surgery or various forms of radiation) for prostate cancer with or without adjuvant or neoadjuvant therapy, and had complete clinical data, including health related quality of life assessments at baseline and through 2 years after treatment. The association between health related quality of life outcomes and different primary therapies with and without adjuvant or neoadjuvant therapy over time was analyzed using a repeated measures mixed model for each primary therapy. Results: A total of 2,204 men met the study criteria. As primary therapy 1,427 patients received radical prostatectomy, 267 received external beam radiation therapy and 510 received brachytherapy. When androgen deprivation therapy was included with radical prostatectomy, brachytherapy or external beam radiation therapy, there was a transient loss of sexual function that improved within 9 months postoperatively. When external beam radiation therapy was given with brachytherapy there was continuous worsening of urinary function and bother through 21 months. Conclusions: Multimodal therapy may lead to declines in health related quality of life especially in the domains of urinary function, urinary bother and sexual function. These effects must be considered and patients must be counseled appropriately before initiation of multimodal therapy.

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Health-Related Quality of Life Results in Pathologic Stage C Prostate Cancer From a Southwest Oncology Group Trial Comparing Radical Prostatectomy Alone With Radical Prostatectomy Plus Radiation Therapy

Abstract: The addition of RT to surgery resulted in more frequent urination, as well as early report of more bowel dysfunction, although bowel function differences disappeared over the 5-year period. The addition of RT did not negatively impact ED.

Cited by 133 publications

References 37 publications

Urinary Diversion for Severe Urinary Adverse Events of Prostate Radiation: Results from a Multi-Institutional Study

Urinary Diversion for Severe Urinary Adverse Events of Prostate Radiation: Results from a Multi-Institutional Study

Counseling patients about sexual health when considering post-prostatectomy radiation treatment

Health Related Quality of Life in Patients Treated With Multimodal Therapy for Prostate Cancer

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