Health-related quality of life predicts length of hospital stay and survival rates for pediatric patients receiving allogeneic hematopoietic cell transplantation

Liu, Yingmei; Jaing, Tang‐Her; Wen, Yu‐Chuan; Chen, Shih-Hsiang; Weng, Pei‐Yin; Lin, Lin; Wu, Chia‐Ling

doi:10.1007/s11136-021-02887-1

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…29 The QoL in the control group decreased significantly at 14d after transplant, which period is a short-term evaluation, and associated with more symptoms. However, it also returned to pre-UCBT at discharge, which was consistent with Liu et al 30 They conducted a prospective longitudinal study and found that health-related QoL decreased at 14-days post-HSCT, but increased at 1 week before hospital discharge. The fast recovery of QoL in the controls might be due to the encouragement to increase physical activity after engraftment.…”

Section: Discussionsupporting

confidence: 86%

Psychological Effects of a Structured Exercise Intervention During Umbilical Cord Blood Transplantation in Children and Adolescents

Huang,

Wu,

et al. 2023

Integr Cancer Ther

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Background: Children and adolescents undergoing umbilical cord blood transplantation (UCBT) are faced with severe fatigue and a decline in quality of life (QoL) during the inpatient period. Objective: To investigate the effect of a structured exercise intervention on fatigue, QoL and clinical outcomes among children and adolescents during UCBT. Methods: In this randomized controlled trial, participants (n = 48) were randomized to a control group (CG: usual care) or an intervention group (IG: a structured exercise intervention). Fatigue and QoL were assessed at hospital admission, 14 days after UCBT, and at discharge using linear mixed model analysis. In addition, engraftment kinetics, supportive treatment, transplant-related complications, and hospital length of stay were derived from medical records. Results: 4 patients completed the study, the IG participated in an average of 2.12 (1.36-2.8) sessions with a duration of 24 (16-34) min weekly, and the total rate of adherence to the training program was 70.59%. For fatigue and QoL, there was a significant effect of time in the control group, with the total score of fatigue decreased from T1 to T2 (73.9vs 60.9, P = .001) and T1 to T3 (73.9vs 65.6, P = .049), and the QoL scores decreased from T1 to T2 (73.9vs 66.1, P = .043). The hospital length of stay was less in the intervention group ( P = .034). Conclusion: Our randomized study indicated that structured exercise interventions might exert a protective effect by attenuating the decline in fatigue and QoL, and shortening duration of hospitalization.

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Section: Discussionsupporting

confidence: 86%