Health‐related quality of life outcomes among breast cancer survivors

Park, Jihye; Rodriguez, Juan L.; O’Brien, Katie M.; Nichols, Hazel B.; Hodgson, M. Elizabeth; Weinberg, Clarice R.; Sandler, Dale P.

doi:10.1002/cncr.33348

Cited by 56 publications

(44 citation statements)

References 43 publications

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“…An interesting finding was that for our analyses, number of comorbidities and QoL were not related. This is in direct contrast to much of the breast cancer survivorship literature [33,34]. However, previous literature has focused on younger or all aged BCS rather than older BCS.…”

Section: Discussionmentioning

confidence: 87%

Comorbidity, cognitive dysfunction, physical functioning, and quality of life in older breast cancer survivors

Crouch

Champion

2021

Support Care Cancer

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Purpose Older breast cancer survivors (BCS) may be at greater risk for cognitive dysfunction and other comorbidities; both of which may be associated with physical and emotional well-being. This study will seek to understand these relationships by examining the association between objective and subjective cognitive dysfunction and physical functioning and quality of life (QoL) and moderated by comorbidities in older BCS. Methods A secondary data analysis was conducted on data from 335 BCS (stages I–IIIA) who were ≥ 60 years of age, received chemotherapy, and were 3–8 years post-diagnosis. BCS completed a one-time questionnaire and neuropsychological tests of learning, delayed recall, attention, working memory, and verbal fluency. Descriptive statistics and separate linear regression analyses testing the relationship of each cognitive assessment on physical functioning and QoL controlling for comorbidities were conducted. Results BCS were on average 69.79 (SD = 3.34) years old and 5.95 (SD = 1.48) years post-diagnosis. Most were stage II (67.7%) at diagnosis, White (93.4%), had at least some college education (51.6%), and reported on average 3 (SD = 1.81) comorbidities. All 6 physical functioning models were significant (p < .001), with more comorbidities and worse subjective attention identified as significantly related to decreased physical functioning. One model found worse subjective attention was related to poorer QoL (p < .001). Objective cognitive function measures were not significantly related to physical functioning or QoL. Conclusions A greater number of comorbidities and poorer subjective attention were related to poorer outcomes and should be integrated into research seeking to determine predictors of physical functioning and QoL in breast cancer survivors.

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Section: Discussionmentioning

confidence: 87%

Comorbidity, cognitive dysfunction, physical functioning, and quality of life in older breast cancer survivors

Crouch

Champion

2021

Support Care Cancer

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“…Prior research has also found that comorbid conditions can have a negative impact on health related QOL [ 28 – 31 ]. A recent prospective cohort study from the United States found that five years after breast cancer diagnosis, reporting one or more comorbid condition was associated with worse health related QOL scores [ 29 ]. Importantly, the study also concluded that poor health related QOL scores, were associated with a significantly increased hazard of all cause mortality [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent prospective cohort study from the United States found that five years after breast cancer diagnosis, reporting one or more comorbid condition was associated with worse health related QOL scores [ 29 ]. Importantly, the study also concluded that poor health related QOL scores, were associated with a significantly increased hazard of all cause mortality [ 29 ]. Similarly, among breast cancer patients receiving chemotherapy, having a greater number of comorbid conditions has also been associated with poorer physical and role functioning, greater pain, worse sleep quality, and fatigue [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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The impact of chronic comorbidities at the time of breast cancer diagnosis on quality of life, and emotional health following treatment in Canada

Arneja

Brooks

2021

PLoS ONE

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Introduction Advances in breast cancer screening and treatment have led to an increasing number of breast cancer survivors. The objective of this study was to determine the impact of comorbidities on self-reported quality of life (QOL) and emotional health following a breast cancer diagnosis and treatment. Methods Women with a personal history of breast cancer (N = 3,372) were identified from the cross-sectional Canadian Partnership Against Cancer (CPAC) Experiences of Cancer Patients in Transitions Survey. Multinomial (nominal) logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the relationship between burden of comorbidities and overall QOL and emotional health (very poor/poor, fair, good, very good). Results Of the 3,372 participants, 57% reported at least one chronic condition at the time of breast cancer diagnosis. As the number of chronic conditions at diagnosis increased, the odds of reporting worse quality of life and emotional health following treatment also increased. Specifically, compared to women reporting very good QOL, for each additional chronic condition, women reported significantly higher odds of reporting good (OR = 1.22, 95% CI: 1.12, 1.32), fair (OR = 1.76, 95% CI: 1.58, 1.96), or poor/very poor (OR = 2.31, 95% CI: 1.86, 2.88) QOL. Similarly, for each additional comorbidity, women reported significantly higher odds of reporting good (OR = 1.17, 95% CI: 1.07, 1.28), fair (OR = 1.63, 95% CI: 1.46, 1.82), or poor/very poor (OR = 2.17, 95% CI: 1.81, 2.60) emotional health, relative to very good emotional health. Conclusion Breast cancer survivors coping with a high comorbidity burden experience worse overall QOL and emotional health following treatment. This highlights the importance of integrating information on comorbidities into survivorship care to improve the experience and overall outcomes of patients with complex needs.

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“…An interesting nding was that for our analyses, number of comorbidities and QoL were not related. This is in direct contrast to much of the breast cancer survivorship literature [33,34]. However, previous literature has focused on younger or all aged BCS rather than older BCS.…”

Section: Discussionmentioning

confidence: 87%

Comorbidity, Cognitive Dysfunction, Physical Functioning and Quality of Life in Older Breast Cancer Survivors

Crouch

Champion

2021

Preprint

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PurposeOlder breast cancer survivors (BCS) may be at greater risk for cognitive dysfunction and other comorbidities; both of which may be associated with physical and emotional well-being. This study will seek to understand these relationships by examining the association between objective and subjective cognitive dysfunction and physical functioning and quality of life (QoL) and moderated by comorbidities in older BCS. MethodsA secondary data analysis was conducted on using data from 335 BCS (Stage I-IIIA) who were ≥60 years of age, received chemotherapy, and were 3-8 years post-diagnosis. BCS completed a one-time questionnaire and neuropsychological tests of learning, delayed recall, attention, working memory and verbal fluency. Descriptive statistics and separate linear regression analyses testing the relationship of each cognitive assessment on physical functioning and QoL controlling for comorbidities were conducted.ResultsBCS were on average 69.79 (SD=3.34) years old and 5.95 (SD=1.48) years post-diagnosis. Most were stage II (67.7%) at diagnosis, White (93.4%), had at least some college education (51.6%) and reported on average 3 (SD=1.81) comorbidities. All 6 physical functioning models were significant (p<.001); with more comorbidities and worse subjective attention identified as significantly related to decreased physical functioning. One model found worse subjective attention was related to poorer QoL (p<.001). Objective cognitive function measures were not significantly related to physical functioning or QoL. ConclusionsA greater number of comorbidities and poorer subjective attention were related to poorer outcomes and should be integrated into research seeking to determine predictors of physical functioning and QoL in breast cancer survivors.

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Health‐related quality of life outcomes among breast cancer survivors

Cited by 56 publications

References 43 publications

Comorbidity, cognitive dysfunction, physical functioning, and quality of life in older breast cancer survivors

Comorbidity, cognitive dysfunction, physical functioning, and quality of life in older breast cancer survivors

The impact of chronic comorbidities at the time of breast cancer diagnosis on quality of life, and emotional health following treatment in Canada

Comorbidity, Cognitive Dysfunction, Physical Functioning and Quality of Life in Older Breast Cancer Survivors

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