Health-related quality of life outcomes in adults with nonmuscle-invasive bladder cancer receiving a mitomycin-containing reverse thermal gel as a primary treatment (Optima II: Phase 2b, single-arm, open-label trial).
Abstract:270 Background: The standard of care for low-grade non‐muscle‐invasive bladder cancer (LG NMIBC) is transurethral resection of the bladder tumor, which can worsen health‐related quality of life (HRQOL). The “OPTimized Instillation of Mitomycin for Bladder Cancer Treatment” (Optima II, clinicaltrials.gov: NCT03558503) is a Phase 2b, open label, single arm, multicenter trial evaluating a nonsurgical alternative as a primary treatment. Patients receive six weekly instillations of UGN-102, a mitomycin-containing … Show more
“…A clinical study has shown the feasibility of hydrogel therapy, with 44 bladder cancer patients achieving complete disease remission within 3 months. 53 However, further observation is necessary to determine long-term outcomes.…”
Section: Current Approaches and Advances For Intravesical Instillatio...mentioning
“…A clinical study has shown the feasibility of hydrogel therapy, with 44 bladder cancer patients achieving complete disease remission within 3 months. 53 However, further observation is necessary to determine long-term outcomes.…”
Section: Current Approaches and Advances For Intravesical Instillatio...mentioning
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