Health‐related quality of life outcomes from a contemporary prostate cancer registry in a large diverse population

Chien, Gary W.; Slezak, Jeff; Harrison, Teresa N.; Jung, Howard; Gelfond, Joy; Zheng, Chengyi; Wu, Eric; Contreras, Richard; Loo, Ronald K.; Jacobsen, Steven J.

doi:10.1111/bju.13843

Cited by 25 publications

(28 citation statements)

References 29 publications

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“…7 RARP potentially reduces the risk of urinary incontinence, because significantly better recovery of continence after RARP has been reported. 7 It has already been reported that in terms of urinary incontinence, HRQOL remains worse at 24 months after RARP compared to other methods of prostate cancer treatment 30 : Our results contrast with this, and the difference in results may be because Chien et al's study included patients who did not complete or had incomplete surveys. In our study, the radiation group included many high-risk patients, and none dropped out.…”

Section: Discussioncontrasting

confidence: 87%

Health Related Quality of Life in Japanese Patients with Localized Prostate Cancer: Comparative Retrospective Study of Robot-Assisted Laparoscopic Radical Prostatectomy Versus Radiation Therapy

et al. 2020

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Background Radical prostatectomy and radiotherapy are standard treatments for localized prostate cancer. When making decisions about treatment, it is important to not only consider medical information such as the patient's age, performance status, and complications, but also the impact on quality of life (QOL) after treatment. Our purpose was to compare health related quality of life (HRQOL) after robot-assisted laparoscopic radical prostatectomy (RARP) versus radiation therapy in Japanese patients with localized prostate cancer retrospectively. Methods Patients with localized prostate cancer receiving RARP or radiotherapy at Tottori University Hospital between October 2010 and December 2014 were enrolled in a retrospective observational study with follow-up for 24 months to December 2016. The Medical Outcome Study 8-Item Short-Form Health Survey was performed before treatment and 1, 3, 6, 12, and 24 months post-treatment. Results Complete responses to the questionnaire were obtained from 154/227 patients receiving RARP, 41/67 patients receiving intensity-modulated radiation therapy, 35/82 patients receiving low dose rate brachytherapy, and 18/28 patients given low dose rate brachytherapy plus external beam radiation therapy. The median physical component summary score of the Medical Outcome Study 8-Item Short-Form Health Survey was significantly lower at 1 month after prostatectomy than radiotherapy, but was similar for both treatments at 3 months, and was significantly higher at 6, 12 and 24 months after prostatectomy. The median mental component summary score was also significantly lower in the prostatectomy group at 1 month, but not from 3 months onwards. Conclusion Our study suggested that HRQOL was inferior at 1 month after RARP, however, recovered at 3 months after RARP and was better than after radiotherapy at 6, 12, and 24 months.

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Section: Discussioncontrasting

confidence: 87%

Health Related Quality of Life in Japanese Patients with Localized Prostate Cancer: Comparative Retrospective Study of Robot-Assisted Laparoscopic Radical Prostatectomy Versus Radiation Therapy

et al. 2020

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“…Radical prostatectomy, a surgical option for localised disease seeking to cure, is primarily meant to remove all malignant tissues while preserving neurovascular bundles and continence mechanism for robust quality outcomes 5. Intraoperatively, the decision is based on a combination of preoperative imaging, biopsy histology and macroscopic assessment.…”

Section: Introductionmentioning

confidence: 99%

Microscale characterization of prostate biopsies tissues using optical coherence elastography and second harmonic generation imaging

Ling

Zhou

et al. 2018

Laboratory Investigation

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Photonics, especially optical coherence elastography (OCE) and second harmonic generation (SHG) imaging are novel high-resolution imaging modalities for characterisation of biological tissues. Following our preliminary experience, we hypothesized that OCE and SHG imaging would delineate the microstructure of prostate tissue and aid in distinguishing cancer from the normal benign prostatic tissue. Furthermore, these approaches may assist in characterisation of the grade of cancer, as well. In this study, we confirmed a high diagnostic accuracy of OCE and SGH imaging in the detection and characterisation of prostate cancer for a large set of biopsy tissues obtained from men suspected to have prostate cancer using transrectal ultrasound (TRUS). The two techniques and methods described here are complementary, one depicts the stiffness of tissues and the other illustrates the orientation of collagen structure around the cancerous lesions. The results showed that stiffness of cancer tissue was approximately 57.63% higher than that of benign tissue (Young’s modulus of 698.43 ± 125.29 kPa for cancerous tissue versus 443.07 ± 88.95 kPa for benign tissue with OCE. Using histology as a reference standard and 600kPa as a cut-off threshold, the data analysis showed sensitivity and specificity of 89.6% and 99.8% respectively. Corresponding positive and negative predictive values were 99.5% and 94.6% respectively. There was a significant difference noticed in terms of Young’s modulus for different Gleason scores estimated by OCE (p value < 0.05). For SHG, distinct patterns of collagen distribution were seen for different Gleason grade disease with computed quantification employing a ratio of anisotropic to isotropic (A: I ratio) and this correlated with disease aggressiveness.

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“…Por fim, Chien et al (2017) concluíram que existem mudanças no funcionamento sexual, independentemente do tipo de tratamento, pois o funcionamento sexual diminui nos primeiros 24 meses, apresentando um declínio maior nos primeiros meses após o doente ser submetido a uma cirurgia. No entanto, o declínio no presente estudo não foi significativo.…”

Section: Discussionunclassified

Quality of life of patients with prostate cancer

et al. 2020

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Health‐related quality of life outcomes from a contemporary prostate cancer registry in a large diverse population

Abstract: Patients' HRQoL after prostate cancer treatment varies by treatment method. Notably, sexual function recovers most for RALP patients. UI remains worse at 24 months after surgery, compared to other methods of prostate cancer treatment.

Cited by 25 publications

References 29 publications

Health Related Quality of Life in Japanese Patients with Localized Prostate Cancer: Comparative Retrospective Study of Robot-Assisted Laparoscopic Radical Prostatectomy Versus Radiation Therapy

Health Related Quality of Life in Japanese Patients with Localized Prostate Cancer: Comparative Retrospective Study of Robot-Assisted Laparoscopic Radical Prostatectomy Versus Radiation Therapy

Microscale characterization of prostate biopsies tissues using optical coherence elastography and second harmonic generation imaging

Quality of life of patients with prostate cancer

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