Health-related quality of life outcome measures for children surviving critical care: a scoping review

Killien, Elizabeth Y; Loftis, Laura; Clark, Jonna D.; Muszynski, Jennifer A.; Rissmiller, Brian; Singleton, Marcy; White, Benjamin R; Zimmerman, Jerry J.; Maddux, Aline B; Pinto, Neethi; Fink, Ericka L.; Watson, R. Scott; Smith, McKenna; Ringwood, Melissa; Graham, Robert J.; Post-Picu,; Investigators, Sepsis

doi:10.1007/s11136-021-02928-9

Cited by 13 publications

(11 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During follow-up, all children and families should be monitored neurocognitive and psychosocially to find those at risk for impaired development and developing morbidities. Since some children and parents have delayed reactions with regard to psychosocial symptoms [ 94 ], this monitoring should be done both short term and long term [ 6 ]. Furthermore, psychosocial interventions should be offered to families at high risk for psychosocial problems.…”

Section: Discussionmentioning

confidence: 99%

“…The four domains could be assessed both subjectively and objectively and give a complete view of the child's daily functioning. Other earlier reviews in the field of PICS-p after PICU admission were done in specific PICU sub-population [5], excluded specific disease processes, interventions or age-groups [5][6][7], or under-recognized the importance of HRQoL as embedded assessment of social and emotional outcomes in validating the PICS-p framework [8,9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review

et al. 2022

View full text Add to dashboard Cite

Objective This study systematically reviewed recent findings on neurocognitive functioning and health-related quality of life (HRQoL) of children after pediatric intensive care unit admission (PICU). Data sources Electronic databases searched included Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar. The search was limited to studies published in the last five years (2015–2019). Study selection Original studies assessing neurocognitive functioning or HRQoL in children who were previously admitted to the PICU were included in this systematic review. Data extraction Of the 3649 identified studies, 299 met the inclusion criteria based on title abstract screening. After full-text screening, 75 articles were included in the qualitative data reviewing: 38 on neurocognitive functioning, 33 on HRQoL, and 4 on both outcomes. Data synthesis Studies examining neurocognitive functioning found overall worse scores for general intellectual functioning, attention, processing speed, memory, and executive functioning. Studies investigating HRQoL found overall worse scores for both physical and psychosocial HRQoL. On the short term (≤ 12 months), most studies reported HRQoL impairments, whereas in some long-term studies HRQoL normalized. The effectiveness of the few intervention studies during and after PICU admission on long-term outcomes varied. Conclusions PICU survivors have lower scores for neurocognitive functioning and HRQoL than children from the general population. A structured follow-up program after a PICU admission is needed to identify those children and parents who are at risk. However, more research is needed into testing interventions in randomized controlled trials aiming on preventing or improving impairments in critically ill children during and after PICU admission.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Future iterations may consider providing guidance for measurement intervals. Although rigorous evaluation of each instrument was not within our scope, more in-depth analysis of candidate measures for the COMS was provided in the scoping review and domain-specific manuscripts (8,29,30). Additionally, the Expert Panel intentionally included pediatric neuropsychologists with expertise in the psychometric properties and evaluation of instruments.…”

Section: Discussionmentioning

confidence: 99%

A Core Outcome Measurement Set for Pediatric Critical Care*

Pinto

Maddux

Dervan

et al. 2022

Pediatric Critical Care Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Clinicians are adopting these measures into clinical practice, and PROMIS measures are integrated into some Epic eMR systems (39,40). There is interest in expanding the use of validated and standardized patient-reported outcome measures and health-related quality of life questionnaires in pediatric critical care medicine (41)(42)(43)(44)(45)(46). Further studies, such as ours, are needed to determine the most appropriate measures of overall health in the pediatric critically ill population (42,45).…”

Section: Discussionmentioning

confidence: 99%

Adverse Childhood Experiences and Patient-Reported Outcome Measures in Critically Ill Children

et al. 2022

View full text Add to dashboard Cite

Adverse childhood experiences (ACEs) are linked to adverse health outcomes for adults and children in the United States. The prevalence of critically ill children who are exposed to ACEs is not known. Our objective was to compare the frequency of ACEs of critically ill children with that of the general pediatric population of Georgia and the United States using publicly available National Survey of Children’s Health (NSCH) data. The impact of ACEs on patient-reported outcome measures of emotional, social, and physical health in critically ill children is not known. We sought to determine whether a higher total number of ACEs was associated with poorer patient-reported measures of emotional, social, and physical health. We conducted a prospective cross-sectional study of children < 18 years of age who were admitted to a 36-bed free-standing, quaternary academic pediatric intensive care unit in Atlanta, Georgia from June 2020—December 2021. Parents of patients who were admitted to the pediatric intensive care unit completed a survey regarding their child’s ACEs, health care use patterns, and patient-reported outcome measures (PROMIS) of emotional, social, and physical health. Prevalence estimates of ACEs were compared with national and state data from the NSCH using Rao-Scott Chi-square tests. PROMIS measures reported within the PICU cohort were compared with population normed T-scores. The association of cumulative ACEs within the PICU cohort with patient-reported outcomes of emotional, social, and physical health were evaluated with a t-test. Among the 84 participants, 54% had ≥ 1 ACE, 29% had ≥ 2 ACEs, and 10% had ≥ 3 ACEs. Children with ≥ 2 ACEs had poorer anxiety and family relationship T-scores compared to those with ≤ 1 ACE. Given the high burden of ACEs in critically ill children, screening for ACEs may identify vulnerable children that would benefit from interventions and support to mitigate the negative effects of ACEs and toxic stress on emotional, social, and physical health.

show abstract

Health-related quality of life outcome measures for children surviving critical care: a scoping review

Cited by 13 publications

References 36 publications

Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review

Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review

A Core Outcome Measurement Set for Pediatric Critical Care*

Adverse Childhood Experiences and Patient-Reported Outcome Measures in Critically Ill Children

Contact Info

Product

Resources

About