Health-related quality of life of children with pre-dialysis chronic kidney disease

Baek, Hee Sun; Kang, Hee Gyung; Choi, Hyun Jin; Cheong, Hae Il; Ha, Il Soo; Han, Kyung Hee; Kim, Seong Heon; Cho, Hee Yeon; Shin, Jae Il; Park, Young-Seo; Lee, Joo Hoon; Lee, Joongyub; Ahn, Curie; Cho, Min Hyun

doi:10.1007/s00467-017-3721-5

Cited by 38 publications

(19 citation statements)

References 21 publications

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“…In addition, patients with CAKUT often have extrarenal manifestations as well, such as hearing loss, neurocognitive disorders, and cardiac anomalies, which affect growth and development. Therefore, many children with CKD resulting from CAKUT experience extrarenal manifestations besides the long-standing CKD, which may also lead to complications such as impairments in physical and psychosocial development [3][4][5] as well as high morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract

Ahn

Lee

Kim

et al. 2020

JCM

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Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in children. The search for genetic causes of CAKUT has led to genetic diagnosis in approximately 5–20 % of CAKUT patients from Western countries. In this study, genetic causes of CAKUT in Korean children were sought using targeted exome sequencing (TES) of 60 genes reported to cause CAKUT in human or murine models. We identified genetic causes in 13.8% of the 94 recruited patients. Pathogenic single nucleotide variants of five known disease-causing genes, HNF1B, PAX2, EYA1, UPK3A, and FRAS1 were found in 7 cases. Pathogenic copy number variations of 6 patients were found in HNF1B, EYA1, and CHD1L. Genetic abnormality types did not significantly differ according to CAKUT phenotypes. Patients with pathogenic variants of targeted genes had syndromic features more frequently than those without (p < 0.001). This is the first genetic analysis study of Korean patients with CAKUT. Only one-seventh of patients were found to have pathogenic mutations in known CAKUT-related genes, indicating that there are more CAKUT-causing genes or environmental factors to discover.

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Section: Introductionmentioning

confidence: 99%

Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract

Ahn

Lee

Kim

et al. 2020

JCM

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“…Child's illness make changes in the family that usually include living location rearrangement, involving of additional individuals in caring for the sick child, and the deterioration of existing social relationships. Parents often establish only new friendships with other sick children's parents which supposed to be beneficial in exchanging experiences; however,it also indicates the affected families' isolation (30) . Any information provided by the parents about changes in the family connected with the child's disease should be taken into consideration during interaction with medical personnel (31) .…”

Section: Discussionmentioning

confidence: 99%

Psychological and Social Status of Children Treated with Renal Dialysis and their Mothers at Tanta City

2020

IJONE

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Background and Aim: Renal dialysis treatment of children with end-stage kidney disease (ESKD) poses various challenges including financial difficulties, social challenges and psychological problems. Parents frequently face financial difficulties as they require more time off work and cannot work overtime. Sickness of a child causes a decline in the financial and socioeconomic status of the family and also hampers its functionality. Moreover, care for those children involves considerable psychological and social stress. This study aimed to assess psychological and social condition of children treated with renal dialysis and their mothers. Materials and Method:The research was conducted on children with End-stage renal disease (ESRD) treated with renal dialysis and their mothers. The total studied population in this study was 40 child and their mothers (N= 40). One tool was used to collect data about the children illness and socio-demographic characteristics. Children psychological and social status is assessed using the Paediatric Quality of Life Inventory (PedsQL)and their parents the PedsQL-proxy version. Mothers health, social, and psychological data were collected using General Health Questionnaire (GHQ-12), and Berlin Social Support Scales(BSSS).Result: Children psychological and social status were significantly low as reported by the children or the mothers who provide primary care for APD children. The mothers perceived available and actually received support is low. Overall score of General Health Questionnaire of the mothers was very high by median and quartile 17 (15)(16)(17)(18).Conclusions: Children psychological and social status were low according to PedsQL test. The family of children with renal dialysis need financial support. Mothers who provide primary care to children on renal dialysis require emotional support and assistance in self fulfillment. The mothers have high GHQ-12 scoring which means that they are have greater chance for increase of non-psychotic mental disorders. There is a strong need to provide continuous psychological care for caregivers.

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“…Moreover, children have a longer life expectancy with a longer time to manifest compli cations related with CKD. Comorbidities of CKD may also lead to complica tions that include impairments in physical and psychosocial development in children 3,4) . Therefore, pediatric CKD requires a higher cost of care per indi vidual than that in adult CKD 5) .…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for the Progression of Chronic Kidney Disease in Children

Ahn¹,

Kang²,

Ha³

2021

Child Kidney Dis

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Chronic kidney disease (CKD) in children is associated with various complications, including poor growth and development, mineral bone disorder, cardiovascular disease, kidney failure, and mortality. Slowing down the progression of CKD is important since CKD is often not curable. Prospective cohort studies have been conducted to understand the progression and outcomes of CKD in children, and these studies have identified non-modifiable and modifiable risk factors. Recognition of known risk factors and early intervention are important to delay the progression of kidney function decline in children.

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Health-related quality of life of children with pre-dialysis chronic kidney disease

Cited by 38 publications

References 21 publications

Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract

Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract

Psychological and Social Status of Children Treated with Renal Dialysis and their Mothers at Tanta City

Risk Factors for the Progression of Chronic Kidney Disease in Children

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