Health-related quality of life of people living with HIV infection in Spain: a gender perspective

Fumaz, Carmina R.; Larrañaga, Maider; Mayordomo-López, Sonia; Martínez, Sandra Gómez; González-García, Marian; Apodaca, María José Fuster Ruiz de; Remor, Eduardo; Ballester‐Arnal, Rafael

doi:10.1080/09540121.2019.1597959

Cited by 18 publications

(20 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All the studies found an association between CD4 count and HRQoL. Some associated low CD4 counts with lower overall HRQoL scores or self-perception of health [46][47][48], while others linked low CD4 count to worse physical health status [49] or mental health status [50,51]. A cross-sectional study using a multidimensional HIV-specific HRQoL measure showed that PWHIV with the lowest CD4 counts had the lowest scores in several HRQoL domains, including physical health status [48].…”

Section: Ahd and Health-related Quality Of Life (Table 3)mentioning

confidence: 99%

“…Some cross-sectional studies [50,51] and longitudinal studies [52,54,56] found that AIDS defining events impaired HRQoL.…”

Section: Ahd and Health-related Quality Of Life (Table 3)mentioning

confidence: 99%

“…Some studies associate worse HRQoL with other variables that are potentially related to HIV disease progression, such as HCV coinfection [46], cART adverse events [50][51][52]54] and medical comorbidities (including HIV-related symptoms and non-AIDS comorbidities) [49,55,56].…”

Section: Ahd and Health-related Quality Of Life (Table 3)mentioning

confidence: 99%

See 2 more Smart Citations

Impact of Advanced HIV Disease on Quality of Life and Mortality in the Era of Combined Antiretroviral Treatment

Portilla-Tamarit

Reus

Portilla

et al. 2021

JCM

View full text Add to dashboard Cite

Currently, AIDS or severe immunodeficiency remains as a challenge for people with HIV (PWHIV) and healthcare providers. Our purpose was to analyze the impact of advanced HIV disease (AHD) on mortality, life expectancy and health-related quality of life (HRQoL). We reviewed cohort studies and meta-analyses conducted in middle- and high-income countries. To analyze HRQoL, we selected studies that reported overall health and/or physical/mental health scores on a validated HRQoL instrument. AIDS diagnosis supposes a higher risk of mortality during the first six months, remaining higher for 48 months. It has been reported that cancer and cardiovascular disease persist as frequent causes of mortality in PWHIV, especially those with previous or current AHD. PWHIV who initiate combination antiretroviral therapy (cART) with CD4 < 200 cells/µL have significantly lower estimated life expectancy than those with higher counts. AHD is associated with lower HRQoL, and a worse physical health or mental health status. AIDS and non-AIDS defining events are significant predictors of a lower HRQoL, especially physical health status. AHD survivors are in risk of mortality and serious comorbidities, needing special clinical attention and preventive programs for associated comorbidities. Their specific needs should be reflected in HIV guidelines.

show abstract

Section: Ahd and Health-related Quality Of Life (Table 3)mentioning

confidence: 99%

“…Some cross-sectional studies [50,51] and longitudinal studies [52,54,56] found that AIDS defining events impaired HRQoL.…”

Section: Ahd and Health-related Quality Of Life (Table 3)mentioning

confidence: 99%

See 1 more Smart Citation

Impact of Advanced HIV Disease on Quality of Life and Mortality in the Era of Combined Antiretroviral Treatment

Portilla-Tamarit

Reus

Portilla

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…HRQoL results are commonly used in clinical trials and regulatory and reimbursement agencies have begun to request these data in their intervention assessment process (9). Precise evaluation of HRQoL with valid measures has become crucial for improving PLWHA quality of life (10,11). Several tools, both generic and disease-speci c, are used to measure HRQoL in PLWHA (4).…”

Section: Introductionmentioning

confidence: 99%

Translation and Cross-Cultural Adaptation of WHOQOL-HIV Bref Among People Living with HIV/AIDS in Pakistan

Ahmed

Saqlain

Akhtar

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Reliable Health-Related Quality of Life (HRQoL) assessment will be useful in identifying health issues and in identifying health care actions. Due to the lack of a psychometrically valid tool in Urdu, we aim to translate and examine the psychometric and cross-cultural adaptation of WHOQOL HIV Bref among people living with HIV/AIDS (PLWHA) in Pakistan. Methods The standard forward-backwards translation technique was used to convert English version of the WHOQOL HIV Bref into Urdu. After cognitive debriefing, final Urdu version of instrument was developed. Based on the principle of at least 5 subjects for each item, a sample of 182 patients was used using a universal random sampling technique from the Pakistan Institute of Medical Sciences, Islamabad. The Cronbach’s alpha and intra-class correlation coefficients (ICC) were estimated to assess internal validity and reliability of the translated version. Exploratory factor analysis was carried out to determine the factor structure and independent associations between the instrument domains and CD-4 T-cell count were assessed using multivariable linear regressionResults High Cronbach alpha 0.93 was found for all WHOQOL HIV Bref facets. The test-retest reliability demonstrated a statistically significant ICC ranged from 0.88 – 0.98 (p < 0.001). In known group validity, lower CD-4 lymphocytes count was significantly related to poor scores for all six domains (p < 0.001). Similarly, symptomatic subjects had significantly lower scores compared to asymptomatic subjects on the physical, psychological, social relationship and independence domains (p < 0.05). Statistically significant positive correlation of all six domains of instrument with CD4 cells count (p < 0.001), exhibiting patients with higher CD-4 cells will have higher mean scores of all domains. Factor analysis revealed 5 domains, including physical health, psychological health, social relationship, environmental, and spiritual health. Multivariable linear regression analysis reported; only physical, psychological health and environment health domains were found significantly associated with higher CD-4 lymphocytes count (Beta = 0.121, p < 0.001, Beta = 0.103, p = 0.002, and Beta = 0.032, p = 0.032).Conclusion Findings suggested that the Urdu version of WHOQOL HIV Bref is a psychometrically valid and culturally well-adapted HRQoL measurement tool for PLWHA in Pakistan.

show abstract

“…Precise evaluation of HRQoL with valid measures has become crucial for improving PLWHA quality of life (14,15). Furthermore, the HRQoL assessment plays a signi cant role in evaluating the outcome of the studied intervention (16).…”

Section: Introductionmentioning

confidence: 99%

Psychometric assessment of translated Urdu version of WHOQOL-HIV BREF among patients living with HIV

Ahmed

Saqlain

Akhtar

et al. 2020

Preprint

View full text Add to dashboard Cite

ObjectiveThe Low Middle Income Countries (LMIC) like Pakistan are facing an escalation in the number of HIV cases, approximately more than 180,000 people are currently living with HIV/AIDS (PLWHA). Currently, no HIV specific Health Related Quality of Life (HRQoL) tool is validated in Pakistan; therefore, the current analysis was aimed at translating and examining the psychometric properties of the Urdu version of WHOQOL HIV BREF among HIV patients of Pakistan.MethodsThe standard forward-backwards translation technique was used for Urdu translation of the instrument. Based on the principle of 5 subjects minimally for each item, a sample of 182 patients were recruited by employing a universal random sampling technique. Data were analysed to measure reliability, internal consistency, known-group, multivariable linear regression and construct validity. Results High internal consistency 0.93 (Cronbach alpha) was found for all WHOQOL HIV Bref facets. The test-retest reliability analysis demonstrated a statistically significant Interclass Correlation Coefficient (ICC) ranged from 0.88 – 0.98 (p < 0.001). In known group validity, lower CD-4 lymphocytes count was significantly related to poor scores for all six domains (p < 0.001). Similarly, symptomatic subjects had significantly lower scores compared to asymptomatic subjects on the physical, psychological, social relationship and independence domains (p < 0.05). Results also revealed a statistically significant positive correlation of all six domains with CD4 count (p < 0.001), exhibiting patients with higher CD-4 lymphocytes count will have higher mean scores of all six domains. Factor analysis revealed 5 domains, including Physical health, Psychological health, Social relationship, Environmental, and Spiritual health. When all domains were assessed together via Multivariable linear regression analysis; only physical, psychological health and environment health domains were found significantly associated with higher CD-4 lymphocytes count (Beta = 0.121, p < 0.001, Beta = 0.103, p = 0.002, and Beta = 0.032, p = 0.032).ConclusionFindings suggested that the Urdu version of WHOQOL HIV Bref is a psychometrically valid tool for measuring HRQoL.

show abstract

Health-related quality of life of people living with HIV infection in Spain: a gender perspective

Cited by 18 publications

References 59 publications

Impact of Advanced HIV Disease on Quality of Life and Mortality in the Era of Combined Antiretroviral Treatment

Impact of Advanced HIV Disease on Quality of Life and Mortality in the Era of Combined Antiretroviral Treatment

Translation and Cross-Cultural Adaptation of WHOQOL-HIV Bref Among People Living with HIV/AIDS in Pakistan

Psychometric assessment of translated Urdu version of WHOQOL-HIV BREF among patients living with HIV

Contact Info

Product

Resources

About