Health-Related Quality of Life Measured with EQ-5D in Patients Treated for Depression in Primary Care

Sobocki, Patrik; Ekman, Mattias; Ågren, Hans; Krakau, Ingvar; Runeson, Bo; Mårtensson, Björn; Jönsson, Bengt

doi:10.1111/j.1524-4733.2006.00162.x

Cited by 138 publications

(128 citation statements)

References 22 publications

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“…Six studies 139,142,144,[147][148][149] investigated the known-group validity of the EQ-5D across severity groups, five studies 129,136,137,143,145 reported convergent validity of the EQ-5D and 14 studies 50,[130][131][132][133][134][135][136][137][138]140,141,145,146 investigated the responsiveness of the EQ-5D. Two studies 139,142 had known-groups differences in the SF-6D, three 132,134,137 had convergent validity and two 136,145 had responsiveness.…”

Section: Depression and Anxietymentioning

confidence: 99%

“…In all, there were 22 studies 50, identified with data on the validity and/or responsiveness of the generic HRQoL measures in depression and anxiety for EQ-5D and SF-6D. Fourteen studies 50,129,[136][137][138][139][142][143][144][145][146][147][148][149] had data on the EQ-5D and seven 130,131,[133][134][135]140,141 contained data on the SF-6D. Studies were undertaken in at least 12 countries (a number covered Europe).…”

Section: Depression and Anxietymentioning

confidence: 99%

See 1 more Smart Citation

A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures

Brazier

Connell

Papaioannou

et al. 2014

Health Technology Assessment

207

187

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This report should be referenced as follows:Brazier J, Connell J, Papaioannou D, Mukuria C, Mulhern B, Peasgood T, et al. A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures. Health Technol Assess 2014;18(34). This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/). Health Technology Assessment is indexed and abstracted inEditorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme or, commissioned/managed through the Methodology research programme (MRP), and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions. To strengthen the evidence base for health research, the MRP oversees and implements the evolving strategy for high quality methodological research. In addition to the MRC and NIHR funding partners, the MRP takes into account the needs of other stakeholders including the devolved administrations, industry R&D, and regulatory/advisory agencies and other public bodies. The MRP funds investigator-led and needsled research proposals from across the UK. In addition to the standard MRC and RCUK terms and conditions, projects commissioned/managed by the MRP are expected to provide a detailed report on the research findings and may publish the findings in the HTA journal, if supported by NIHR funds.The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy o...

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Section: Depression and Anxietymentioning

confidence: 99%

Section: Depression and Anxietymentioning

confidence: 99%

A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures

Brazier

Connell

Papaioannou

et al. 2014

Health Technology Assessment

207

187

View full text Add to dashboard Cite

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“…The EQ-5D has been validated in UK populations and has been used to measure HRQoL in patients with depression in primary care. [49][50][51] Resource use data Information relating to participants' resource utilisation was obtained via two measures: completion of a self-report questionnaire (an adapted CSRI) and objective data collection from GP medical records.…”

mentioning

confidence: 99%

A randomised controlled trial of computerised cognitive behaviour therapy for the treatment of depression in primary care: the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial

Littlewood

Duarte

Hewitt

et al. 2015

Health Technol Assess

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BackgroundComputerised cognitive behaviour therapy (cCBT) has been developed as an efficient form of therapy delivery with the potential to enhance access to psychological care. Independent research is needed which examines both the clinical effectiveness and cost-effectiveness of cCBT over the short and longer term.ObjectivesTo compare the clinical effectiveness and cost-effectiveness of cCBT as an adjunct to usual general practitioner (GP) care against usual GP care alone, for a free-to-use cCBT program (MoodGYM; National Institute for Mental Health Research, Australian National University, Canberra, Australia) and a commercial pay-to-use cCBT program (Beating the Blues®; Ultrasis, London, UK) for adults with depression, and to determine the acceptability of cCBT and the experiences of users.DesignA pragmatic, multicentre, three-armed, parallel, randomised controlled trial (RCT) with concurrent economic and qualitative evaluations. Simple randomisation was used. Participants and researchers were not blind to treatment allocation.SettingPrimary care in England.ParticipantsAdults with depression who scored ≥ 10 on the Patient Health Questionnaire-9 (PHQ-9).InterventionsParticipants who were randomised to either of the two intervention groups received cCBT (Beating the Blues or MoodGYM) in addition to usual GP care. Participants who were randomised to the control group were offered usual GP care.Main outcome measuresThe primary outcome was depression at 4 months (PHQ-9). Secondary outcomes were depression at 12 and 24 months; measures of mental health and health-related quality of life at 4, 12 and 24 months; treatment preference; and the acceptability of cCBT and experiences of users.ResultsClinical effectiveness:210 patients were randomised to Beating the Blues, 242 patients were randomised to MoodGYM and 239 patients were randomised to usual GP care (total 691). There was no difference in the primary outcome (depression measured at 4 months) either between Beating the Blues and usual GP care [odds ratio (OR) 1.19, 95% confidence interval (CI) 0.75 to 1.88] or between MoodGYM and usual GP care (OR 0.98, 95% CI 0.62 to 1.56). There was no overall difference across all time points for either intervention compared with usual GP care in a mixed model (Beating the Blues versus usual GP care,p = 0.96; and MoodGYM versus usual GP care,p = 0.11). However, a small but statistically significant difference between MoodGYM and usual GP care at 12 months was found (OR 0.56, 95% CI 0.34 to 0.93). Free-to-use cCBT (MoodGYM) was not inferior to pay-to-use cCBT (Beating the Blues) (OR 0.91, 90% CI 0.62 to 1.34;p = 0.69). There were no consistent benefits of either intervention when secondary outcomes were examined. There were no serious adverse events thought likely to be related to the trial intervention. Despite the provision of regular technical telephone support, there was low uptake of the cCBT programs.Cost-effectiveness:cost-effectiveness analyses suggest that neither Beating the Blues nor MoodGYM appeared cost-effective compared with usual GP care alone.Qualitative evaluation:participants were often demotivated to access the computer programs, by reason of depression. Some expressed the view that a greater level of therapeutic input would be needed to promote engagement.ConclusionsThe benefits that have previously been observed in developer-led trials were not found in this large pragmatic RCT. The benefits of cCBT when added to routine primary care were minimal, and uptake of this mode of therapy was relatively low. There remains a clinical and economic need for effective low-intensity psychological treatments for depression with improved patient engagement.Trial registrationThis trial is registered as ISRCTN91947481.FundingThis project was funded by the National Institute for Health Research Health Technology Assessment programme.

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“…Depression is related to an impaired quality of life and ability to engage in social interactions, interpersonal relationships, and activities of independent living [30]. It is believed that depression is often caused by the influence of more than a single factor [31].…”

Section: Clinical Manifestations Of Depression In Caregiversmentioning

confidence: 99%

Treating Depression in the Caregivers of Cancer Patients

Louis¹

2017

JPCPY

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Partners often assume the role of caregiver when cancer is brought into the home. The support caregivers provide to cancer patients has immeasurable value. However, care giving can take a significant toll on loved ones from both a psychological and physiological perspective; sometimes to the point of producing caregiver burden. One of the diseases most prevalent in caregivers is depression. Signs and symptoms of depression amongst caregivers vary from mild to severe and people respond quite differently to the life stressors they face. While, the exact cause of depression is not known, proven research correlates it with an internal chemical and/or neurotransmitter imbalance that can be triggered by stress, chronic stress in particular. As a mood disorder, depression affects how you feel, think, and function in the performance of your daily activities. It is critically important to identify caregivers exhibiting depressive symptoms and first, to provide them with both emotional and psychological support, and second, so as to ensure the individual battling cancer receives optimal support from their loved ones. This review article serves to promote health awareness and the unmet needs of cancer patient caregivers, the presence of caregiver burden, and the impact that stress can have on one's neurophysiological processes to precipitate the development of mental illness such as depression.

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Health-Related Quality of Life Measured with EQ-5D in Patients Treated for Depression in Primary Care

Cited by 138 publications

References 22 publications

A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures

A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures

A randomised controlled trial of computerised cognitive behaviour therapy for the treatment of depression in primary care: the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial

Treating Depression in the Caregivers of Cancer Patients

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