Health-related Quality of Life Measured by the EORTC QLQ-C30: Reference Values From a Large Sample of the Swedish Population

Michelson, Helena; Bolund, Christina; Nilsson, Bo; Brandberg, Yvonne

doi:10.1080/028418600750013384

Cited by 296 publications

(67 citation statements)

References 32 publications

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“…This difference was pronounced in the psychological and social domains of HRQoL. The relationship between having a job and a better perceived HRQoL was also found in previous studies in the general population43, 44 and other patient populations 45, 46. Employment is important to the patients, as it provides them with an income, opportunities to structure their daily lives, and satisfying social interactions, all of which can affect HRQoL.…”

Section: Discussionsupporting

confidence: 64%

Patient-reported health outcomes in long-term lung transplantation survivors: A prospective cohort study

Parizi

Krabbe

Verschuuren

et al. 2018

American Journal of Transplantation

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During the last three decades lung transplantation (LTx) has become a proven modality for increasing both survival and health‐related quality of life (HRQoL) in patients with various end‐stage lung diseases. Most previous studies have reported improved HRQoL shortly after LTx. With regard to long‐term effects on HRQoL, however, the evidence is less solid. This prospective cohort study was started with 828 patients who were on the waiting list for LTx. Then, in a longitudinal follow‐up, 370 post‐LTx patients were evaluated annually for up to 15 years. For all wait‐listed and follow‐up patients, the following four HRQoL instruments were administered: State‐Trait Anxiety Inventory, Zung Self‐rating Depression Scale, Nottingham Health Profile, and a visual analogue scale. Cross‐sectional and generalized estimating equation (GEE) analysis for repeated measures were performed to assess changes in HRQoL during follow‐up. After LTx, patients showed improvement in all HRQoL domains except pain, which remained steady throughout the long‐term follow‐up. The level of anxiety and depressive symptoms decreased significantly and remained constant. In conclusion, this study showed that HRQoL improves after LTx and tends to remain relatively constant for the entire life span.

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Section: Discussionsupporting

confidence: 64%

Patient-reported health outcomes in long-term lung transplantation survivors: A prospective cohort study

Parizi

Krabbe

Verschuuren

et al. 2018

American Journal of Transplantation

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“…We have made similar observations in our patient material [36, 37], where plasma CgA levels were followed together with other markers; CgA measurements are the most reliable markers in the follow-up of treatment. Furthermore, increases in plasma CgA usually precede radiological evidence of progression.…”

Section: Plasma and Serum Measurementssupporting

confidence: 53%

“…In a previous study of midgut carcinoid patients, who had undergone surgery and after surgery small residual lymph node metastases were left, measurement of plasma CgA was compared to urinary 5-HIAA [36]. In this group of 25 patients with limited disease, all had elevated plasma CgA, whereas only 3 had elevations of urinary 5-HIAA.…”

Section: Plasma and Serum Measurementsmentioning

confidence: 99%

Tumor Markers in Neuroendocrine Tumors

Eriksson

Öberg²,

Stridsberg³

2000

Digestion

254

162

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Most neuroendocrine tumors produce and secrete a multitude of peptide hormones and amines. Some of these substances cause a specific clinical syndrome: carcinoid, Zollinger-Ellison, hyperglycemic, glucagonoma and WDHA syndrome. Specific markers for these syndromes are basal and/or stimulated levels of urinary 5-HIAA, serum or plasma gastrin, insulin, glucagon and vasoactive intestinal polypeptide, respectively. Some carcinoid tumors and about one third of endocrine pancreatic tumors do not present any clinical symptoms and are called ‘nonfunctioning’ tumors. Therefore, general tumor markers such as chromogranin A, pancreatic polypeptide, serum neuron-specific enolase and subunits of glycoprotein hormones have been used for screening purposes in patients without distinct clinical hormone-related symptoms. Among these general tumor markers chromogranin A, although its precise function is not yet established, has been shown to be a very sensitive and specific serum marker for various types of neuroendocrine tumors. This is because it may also be elevated in many cases of less well-differentiated tumors of neuroendocrine origin that do not secrete known hormones. At the moment, chromogranin A is considered the best general neuroendocrine serum or plasma marker available both for diagnosis and therapeutic evaluation and is increased in 50–100% of patients with various neuroendocrine tumors. Chromogranin A serum or plasma levels reflect tumor load, and it may be an independent marker of prognosis in patients with midgut carcinoids.

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“…The largest differences between the study group and a selected reference group (age group 60–69 and male) from Swedish population norm for QLQ-C30 were found for diarrhoea (–32 points), followed by dyspnoea and appetite loss (–12 points), fatigue (–10 points) and global quality of life (–8 points) [19, 20]. For the other scales and single items the difference was less than 5 points.…”

Section: Resultsmentioning

confidence: 99%

“…In this study two internationally validated HRQL-questionnaires, the EORTC QLQ-C30 and the EORTC QLQ-OES18, were used to evaluate HRQL. After 2 years the study group’s general functions, such as their physical, emotional and social functioning harmonised with population norms in Sweden [18, 19]. The global quality of life score was somewhat lower for the study group compared to population norms but the difference did not reach significance.…”

Section: Discussionmentioning

confidence: 99%

Physical Function and Quality of Life after Thoracoabdominal Oesophageal Resection

2005

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Background: The long-term functional outcome after thoracoabdominal resection has to be better evaluated. A study was performed to evaluate patients after a similar operation both in terms of physical function and health-related quality of life (HRQL). Methods: Eighteen patients were evaluated 2 years after a thoracoabdominal resection. Respiratory function, physical performance and range of motion in shoulder, thorax and spine were recorded. HQRL was assessed by EORTC QLQ-C30 (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30) and EORTC QLQ-OES18 (Oeophageal module). Results: Two years after surgery, respiratory function (forced vital capacity and forced expiratory volume in 1 s) was significantly impaired compared to preoperative values (p < 0.05). The physical performance was significantly reduced as measured by a functional stand-up test (p < 0.05) and the handgrip force (p < 0.001). Shoulder range of motion, thoracic lateral flexion and C7 to wall were within normal ranges, thoracic flexion significantly greater (p < 0.01) but chest expansion significantly decreased (p < 0.01) compared to controls. HQRL was comparable to age- and sex-matched population norms for most of the functions. A clinical significant difference was, however, found for diarrhoea, dyspnoea, appetite loss and fatigue. Conclusion: Within a 2-year period, each individual regains most of the respiratory and physical performances and HRQL after a thoracoabdominal resection.

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Health-related Quality of Life Measured by the EORTC QLQ-C30: Reference Values From a Large Sample of the Swedish Population

Cited by 296 publications

References 32 publications

Patient-reported health outcomes in long-term lung transplantation survivors: A prospective cohort study

Patient-reported health outcomes in long-term lung transplantation survivors: A prospective cohort study

Tumor Markers in Neuroendocrine Tumors

Physical Function and Quality of Life after Thoracoabdominal Oesophageal Resection

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