Health related quality of life in male patients with osteoporosis: results of a cross sectional study

Voigt, Karen; Taché, Stéphanie; Hofer, Matthias; Straßberger, C.; Riemenschneider, Henna; Peschel, Peter; Kügler, Joachim; Bergmann, Antje

doi:10.3109/13685538.2012.716877

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…Osteoporosis can lead to multiple adverse consequences, including chronic pain, fragility fractures, sarcopenia, physical disability, which may impair the quality of life of the patients [ 28 , 29 ]. We evaluated the HRQoL of Chinese men with primary osteoporosis or osteopenia in detail for the first time, and confirmed that the poorer quality of life in osteoporotic men than healthy controls, especially in the physical function domain.…”

Section: Discussionmentioning

confidence: 99%

“…Two meta-analysis studies demonstrated that HRQoL of men with osteoporosis was impaired more obviously in physical function than mental function, which were consistent with our results [ 12 , 14 , 30 ]. Through EQ-5D questionnaire, another study found that pain/discomfort and anxiety/depression were common in men with osteoporosis [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Health-related quality of life of men with primary osteoporosis and its changes after bisphosphonates treatment

Zhao

Lin

et al. 2023

BMC Musculoskelet Disord

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Introduction Osteoporosis leads to more serious consequences in men than in women, but less is known about its impacts on health-related quality of life (HRQoL) of men, and whether the anti-osteoporosis treatment can improve HRQoL of men with osteopenia/osteoprosis. Methods We enrolled men with primary osteoporosis and age-matched healthy controls. We collected medical history, serum levels of carboxyl-terminal type I collagen telopeptide, procollagen type I propeptides, and bone mineral density of patients. All patients and controls completed the short-form 36 (SF-36) questionnaires. Changes in HRQoL of osteopenia/osteoporosis men were prospectively evaluated after alendronate or zoledronic acid treatment. Results A total of 100 men with primary osteoporosis or osteopenia and 100 healthy men were included. The patients were divided into three subgroups: osteopenia (n = 35), osteoporosis (n = 39) and severe osteoporosis (n = 26). Men with osteoporosis or severe osteoporosis had impaired HRQoL in domains of physical health compared to healthy controls. HRQoL scores in physical health related domains of patients with severe osteoporosis were significantly lower compared to healthy controls, and were the poorest among the three subgroups of patients. Fragility fracture history was correlated with lower SF-36 scores about physical health. In 34 men with newly diagnosed osteoporosis receiving bisphosphonates treatment, HRQoL scores were significantly improved in domains of physical health after treatments. Conclusions The HRQoL is significantly impaired in men with osteoporosis, and the more severe the osteoporosis, the poorer the HRQoL. Fragility fracture is an important influencing factor of deteriorated HRQoL. Bisphosphonates treatment is beneficial to improve HRQoL of osteopenia/osteoporosis men.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Health-related quality of life of men with primary osteoporosis and its changes after bisphosphonates treatment

Zhao

Lin

et al. 2023

BMC Musculoskelet Disord

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“…This study indicates that patients diagnosed with vertebral fractures might benefit from case finding for mood disorders, such as depression, a risk factor for suicide, and enquiring about suicide and self-harm. 40 Osteoporosis is commonly diagnosed and patients seek help for fracture care in primary care, which may therefore be an important setting to identify patients at risk of self-harm and suicide and intervene early. New research would enable the assessment of the feasibility, acceptability, and effectiveness of such approaches.…”

Section: Discussionmentioning

confidence: 99%

Osteoporosis and fracture as risk factors for self-harm and suicide: a systematic review and meta-analysis

et al. 2023

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Background: Increase in presentations of self-harm to primary care, a risk factor of suicide has led to a growing interest in identifying at-risk populations. Aim: To examine whether osteoporosis or fractures are risk factors for self-harm, suicidal ideation, and suicide. Design and Setting: Systematic review of observational studies in adults (18> years) which had examined the role of osteoporosis and/or fractures in subsequent self-harm, suicidal ideation, and/or suicide. Method: Six databases were searched from inception to July 2019. Additional citation tracking of eligible studies was done in November 2022. Screening, data extraction and quality assessment of full-text articles were performed independently by at least two authors. Where possible, meta-analysis was run on comparable risk estimates. Results and Conclusion: Fifteen studies were included, two examined the outcome of self-harm, three suicidal ideation and 10 suicide. In approximately half of studies on osteoporosis, the risk of suicidal ideation and suicide remained significant. However, pooling of adjusted odds ratios from three studies indicated no association between osteoporosis and suicide (1.14(95% confidence interval 0.88-1.49)). Nine studies examined the risk of a mixture of fracture types across different outcomes, limiting comparisons. However, all studies examining vertebral fracture (n=3) reported a significant adjusted negative association for self-harm and suicide. In conclusion, Patients with vertebral fractures may benefit from case-finding for mood disorders in primary care, which are risk factors for suicide, and the subsequent management. However, due to the limited number and quality of studies and mixed findings, further examination of these associations is warranted.

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Osteoporosis Assessment Questionnaire-Physical Function (OPAQ-PF): a psychometrically validated osteoporosis-targeted patient reported outcome measure of daily activities of physical function

et al. 2014

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SummaryThe purpose of this study was to evaluate the measurement properties of the Osteoporosis Assessment Questionnaire-Physical Functioning (OPAQ-PF). Based on this study, the OPAQ-PF has confirmed unidimensionality and acceptable reliability, construct validity, and sensitivity to change in a recent fracture/no recent fracture osteoporosis sample.MethodsDimensionality was established through exploratory and confirmatory factor analysis. Patients completed three patient reported outcome (PRO) measures and four performance-based measures (PBMs) at baseline to enable an evaluation of construct validity. Patients without a recent fracture completed the OPAQ-PF 2 weeks after baseline to enable an evaluation of test–retest reliability. Ability to detect change and interpretation of change were investigated following completion of the OPAQ-PF 12 and 24 weeks postbaseline by patients with a recent fracture.ResultsA prospective psychometric validation study in 144 postmenopausal women, with moderate to severe osteoporosis, 37 of whom had experienced a recent fragility fracture (<6 weeks). Unidimensionality was established for the OPAQ-PF by factor analysis. The OPAQ-PF had good internal consistency (α = 0.974) and test–retest reliability (mean intraclass correlation coefficient (ICC) 0.993. The OPAQ-PF differentiated between patients with/without recent fracture, and by severity of osteoarthritis; it correlated strongly with hypothesized-related scales and PBMs (r > 0.3, p < 0.001). Ability to detect change was established with high correlations between changes in OPAQ-PF score and changes in global concept scores in recent fracture patients (r ≥ 0.6, 24-week change). Effect size of change on OPAQ-PF score increased by level of global change (p < 0.001). Anchor-based methods identified an OPAQ-PF change of 10 at an individual patient level and 20 at a group level as meaningful to patients.ConclusionsThe OPAQ-PF has confirmed unidimensionality and acceptable reliability, construct validity, and sensitivity to change in a recent fracture/no recent fracture osteoporosis sample.

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Health related quality of life in male patients with osteoporosis: results of a cross sectional study

Cited by 8 publications

References 25 publications

Health-related quality of life of men with primary osteoporosis and its changes after bisphosphonates treatment

Health-related quality of life of men with primary osteoporosis and its changes after bisphosphonates treatment

Osteoporosis and fracture as risk factors for self-harm and suicide: a systematic review and meta-analysis

Osteoporosis Assessment Questionnaire-Physical Function (OPAQ-PF): a psychometrically validated osteoporosis-targeted patient reported outcome measure of daily activities of physical function

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