Health‐related quality of life in patients with esophageal cancer or precancerous lesions assessed by EQ‐5D: A multicenter cross‐sectional study

Wang, Youqing; Shi, Jufang; Du, Lingbin; Huang, Huiyao; Wang, Le; Zhu, Juan; Li, Huizhang; Bai, Yana; Liao, Xianzhen; Mao, Ayan; Liu, Guoxiang; Ren, Jiansong; Sun, Xiaojie; Gong, Jiyong; Zhou, Qi; Mai, Linh; Zhu, Lin; Xing, Xiaojing; Liu, Yuqin; Ren, Ying; Song, Bingbing; Li, Lan; Zhou, Jinyi; Lou, Peian; Sun, Xiaohua; Qi, Xiao; Wu, Shouling; Wei, Wenqiang; Zhang, Kai; Dai, Min; Chen, Wanqing; He, Jie

doi:10.1111/1759-7714.13368

Cited by 19 publications

(13 citation statements)

References 61 publications

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“…utility index compared to other FACT-G and EQ-VAS subscale. Previous research showed that mapping studies tended to con rm the predictive ability of health utility more easily when exploring the correlation between the EQ-5D and FACT-G scales [3,32,33]. Furthermore, the SFWB was also not statistically associated with the EQ-5D utility index due to the lack of socialrelated functions [23].…”

Section: Discussionmentioning

confidence: 99%

Mapping the FACT-G to EQ-5D Utility Index in Cancer: Data From a Cross-sectional Study in China

He¹,

Yang²,

Liang³

et al. 2020

Preprint

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ObjectiveThis study aimed to develop a function for mapping the cancer-specific instrument (FACT–G) to a preference-based measure (EQ-5D-3L) utility index for HRQoL, in which the utility scores were generated using the Chinese value set.MethodThe data are based on a cross-sectional survey of 243 patients in China with different cancer types. Cancer patients who completed the EQ-5D-3 L and the FACT-G questionnaire, and patient demographics and clinical characteristics were included in this study. Regression models were used to predict the EQ-5D-3L utility index values based on four subscale scores of the FACT-G using the ordinary least squares (OLS) model, generalized linear models (GLM), censored least absolute deviations (CLAD), Tobit model, and two-part model (TPM) regression approaches. The performance and predictive power of each model were also evaluated using r2 and adj- r2, mean absolute error (MAE) and root mean squared error (RMSE).ResultsThe introduction of the square term and the interaction term improves the accuracy of the model. The social well-being subscale of the FACT-G was not associated with the EQ-5D-3L utility index, whereas, the physical, emotional, functional well-being, and FACT-G total scores were derived when mapping the FACT-G to the EQ-5D-3L utility index. For the FACT-G, the OLS model was the best at predicting mean EQ-5D-3L values among all the regression models and has 70% explanatory power for the observed EQ-5D-3L variation. Nevertheless, the OLS model overpredicted utilities for poorer health states and underestimated utilities for those with better health. The result of the OLS model, GLM, and CLAD models were similar to the MAE, MSE, and RMSE.ConclusionThe algorithm based on Chinese population development for mapping the FACT-G into the EQ-5D-3L utility index can be realized. We also recommend that OLS models be used to assess the economic evaluation of patients' health-related quality of life when the population is in moderate to good health for further cost-utility analysis in China.

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Section: Discussionmentioning

confidence: 99%

Mapping the FACT-G to EQ-5D Utility Index in Cancer: Data From a Cross-sectional Study in China

He¹,

Yang²,

Liang³

et al. 2020

Preprint

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“…All the items related to costs were assumed to inflate at the same inflation rate of 4.7% [ 24 ]. State-specific utilities were extracted from published papers [ 25 – 27 ]. A discount rate of 5% was used for both costs and effectiveness [ 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Modeling the Cost-effectiveness of Esophageal Cancer Screening in China

Wang

et al. 2020

Cost Eff Resour Alloc

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Background This study aimed to examine the cost-effectiveness of one-time standard endoscopic screening with Lugol’s iodine staining for esophageal cancer (EC) in China. Methods A Markov decision analysis model with eleven states was built. Individuals aged 40 to 69 years were classified into six age groups in five-year intervals. Three different strategies were adopted for each cohort: (1) no screening; (2) one-time endoscopic screening with Lugol’s iodine staining with an annual follow-up for low-grade intraepithelial neoplasia (LGIN); and (3) one-time endoscopic screening with Lugol’s iodine staining without follow-up. Quality-adjusted life-years (QALYs) indicated the effectiveness of the model. The incremental cost-effectiveness ratio (ICER) was used as the evaluation indicator. Sensitivity analysis was performed to assess the robustness of the model. Results One-time screening with follow-up was the undominated strategy for individuals aged 40–44 and 45–49 years, which saved USD 10,942.57 and USD 6611.73 per QALY gained compared to nonscreening strategy. For those aged 50–69 years, the nonscreening scenarios were undominated. One-time screening without follow-up was the extended dominated strategy. Compared to screening strategies without follow-up, all the screening strategies with follow-up were more cost-effective, with the ICER increasing from 299.57 USD/QALY for individuals aged 40–44 years to 1617.72 USD/QALY for individuals aged 65–69 years. Probabilistic sensitivity analysis (PSA) supported the results of the base case analysis. Conclusions One-time EC screening with follow-up targeting individuals aged 40–49 years was the most cost-effective strategy.

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“…The questionnaire consists of five dimensions, i.e., responder's mobility, self-care, usual activities, pain or discomfort, and anxiety or depression; each dimension has three response levels (1 = no problems, 2= moderate problems and 3 = extreme problems). We employed the Chinese time trade-off values for EQ-5D-3L to measure the utility values of the EQ-5D-3L [28], which has also been widely used in other studies [29,30]. The overall utility values of EQ-5D-3L ranges from -0.149 (having extreme problems) to 1 (no problems).…”

Section: Methodsmentioning

confidence: 99%

The Effects of Family Physician–contracted Service on Health-related Quality of Life and Equity in Health Among the Chinese Population

Lai

Zhou

et al. 2020

Preprint

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Background Family physician–contracted service (FPCs) has been recently implemented in Chinese primary care settings. This study was aimed at measuring the effects of FPCs on residents’ health-related quality of life (HRQoL) and equity in health among the Chinese population. Methods The study data was drawn from the 2018 household health survey (Shaanxi Province, China) using multistage, stratified cluster random sampling. We measured HRQoL using EQ-5D-3L based on the Chinese-specific time trade-off values set. Coarsened exact matching (CEM) technique was used to control for confounding factors between residents with and without a contracted family physician. The concentration index (C) was calculated to measure equity in health. Results Individuals with a contracted family physician had significantly higher HRQoL than those without, after data matching (0.9355, 95% CI: 0.9302–0.9409 vs. 0.8995, 95% CI: 0.8926–0.9063; P < 0.001). Additionally, the inequity in HRQoL among respondents with a contracted family physician was significantly lower than those without a contracted FP (Cs of EQ-5D utility score: 0.0084, 95% CI: 0.0047–0.0122 vs. 0.0263, 95% CI: 0.0187–0.0340; p < 0.001). Conclusions This study highlights the positive effects of FPCs on HRQoL and socioeconomic-related equity in HRQoL. Future efforts should prioritize the economically and educationally disadvantaged groups, the expansion of service coverage, and the competency of family physician teams to further enhance health outcome and equity in health.

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Health‐related quality of life in patients with esophageal cancer or precancerous lesions assessed by EQ‐5D: A multicenter cross‐sectional study

Cited by 19 publications

References 61 publications

Mapping the FACT-G to EQ-5D Utility Index in Cancer: Data From a Cross-sectional Study in China

Mapping the FACT-G to EQ-5D Utility Index in Cancer: Data From a Cross-sectional Study in China

Modeling the Cost-effectiveness of Esophageal Cancer Screening in China

The Effects of Family Physician–contracted Service on Health-related Quality of Life and Equity in Health Among the Chinese Population

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