Health-related quality of life in women with polycystic ovary syndrome attending to a tertiary hospital in Southeastern Spain: a case-control study

Abstract

Background: Polycystic ovary syndrome (PCOS) is a chronic condition with symptoms affecting many women at reproductive age and evaluating their health-related quality of Life (HRQoL) is an important issue. Moreover, differences in the HRQoL between women with different PCOS phenotypes have never been analyzed. Therefore, the aim of our study was to compare the HRQoL between women with PCOS-and its phenotypes-and controls attending to a tertiary hospital. Methods: A group of 117 women with PCOS and 153 controls were studied between 2014 and 2016. Controls were women without PCOS attending the gynecological outpatient clinic for routine examinations. Cases were women attending the same setting and diagnosed with PCOS. PCOS diagnose was performed following the Rotterdam Criteria and women were further classified by anovulatory or ovulatory phenotypic subtype. Women underwent physical and gynecological exams and completed health questionnaires including the Short Form-12v2. Eight scales and two component summary scores [Physical (PCS) and Mental (MCS), respectively] were calculated. Bivariate and multivariate analyses were performed to assess differences in HRQoL between women with PCOS and controls. Results: All women with PCOS and anovulatory PCOS presented lower score in PCS compared to controls [mean (95%CI): 53.7 (52.5-54.9) and 52.9 (51.5-54.4) vs. 55.8 (54.8-56.8); p-values< 0.01], as well as lower scores for five out of the eight scales (p-values < 0.05) after adjusting by age, body mass index, infertility, educational level and current occupation. No significant differences were observed for the MCS between women with or without PCOS or its phenotypic subtypes. Conclusions: HRQoL was significantly decreased in adult women with PCOS and its anovulatory phenotype compared to controls attending the outpatient clinic of a tertiary hospital. These results may have implications for the clinical practice and suggest the need for specific interventions in women with PCOS.

Are Dietary Indices Associated with Polycystic Ovary Syndrome and Its Phenotypes? A Preliminary Study

“…Exclusion criteria were pregnancy or lactating, oncological treatment, hormonal medication during the three months prior to the study, genitourinary prolapse or endocrine disorders ( n = 5). Methods were explained in previous works [ 35 , 36 , 37 , 38 ]. Figure 1 shows the number of participants and the exclusion criteria.…”

Lifestyle and psychosocial risks among women with polycystic ovary syndrome and insulin resistance

“…Wśród objawów klinicznych PCOS, które w największym stopniu wpływają na jakość życia pacjentek, należy wyróżnić otyłość, owłosienie typu męskiego, trądzik, zaburzenia miesiączkowania oraz niepłodność [14]. Badania własne wykazały, że nadmierna masa ciała występowała u ponad połowy pacjentek, a średnia wartość BMI odpowiadała nadwadze, co zostało potwierdzone przez innych badaczy [15][16][17][18][19][20]. Uzyskane wyniki odbiegały jednak znacząco od tych przedstawionych przez S. Sidra i wsp.…”

“…Sánchez-Ferrer i wsp. (2020) [16], podczas gdy odsetek kobiet przyjmujących napoje alkoholowe co najmniej raz w tygodniu był taki sam jak odsetek uzyskany w badaniach B. Zhang i wsp. (2020) [19].…”

Exacerbated health related quality of life amid morbidly Obese PCOS women from Faisalabad, Pakistan

“…Asian Muslim women with PCOS migrated to Austria were faced greater psychological problems [35] while another study on PCOS women from Brazil reported the psychological distress positively associated with changes in appearance like obesity, acne and hirsutism [36]. Lately studies from Spain [37] and UK have shown the prominent concern about weight and infertility among PCOS women [38] and re ected the poor quality of life among PCOS women with overweight or obesity [30].…”