Health-related quality of life in type 2 diabetic patients

Al-Shehri, AmerH; Taha, AttiaZ; Bahnassy, AhmedA; Salah, Mohammad

doi:10.4103/0256-4947.51687

Cited by 47 publications

(63 citation statements)

References 18 publications

(30 reference statements)

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“…Previous studies have not been able to demonstrate the combined impact of T2DM and impaired HRF on mortality because their samples included only people with diabetes (11,12). Research has shown that people with T2DM are more likely to experience impaired HRF compared with populations without diabetes (5,7,10). It is also well established that hyperglycemia promotes CVD risk through various mechanisms, including inflammation and endothelial dysfunction (19), which consequently increase atherosclerosis and plaque rupture.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is increasing evidence to suggest that poor HRF may predict the development of disease, e.g., in type 2 diabetes (T2DM) (8) and CVD (9). Because of the burden of the daily management of T2DM and the development of complications, HRF is particularly important for people with T2DM, with levels of health status shown to be compromised in these populations (5,7,10). Findings from previous studies show that in samples of patients with T2DM, persons reporting low levels of HRF have higher risk of mortality compared with those reporting high functioning (11,12).…”

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confidence: 99%

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Risk of Cardiovascular and All-Cause Mortality: Impact of Impaired Health-Related Functioning and Diabetes

et al. 2012

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OBJECTIVE There is an established link between health-related functioning (HRF) and cardiovascular disease (CVD) mortality, and it is known that those with diabetes predominantly die of CVD. However, few studies have determined the combined impact of diabetes and impaired HRF on CVD mortality. We investigated whether this combination carries a higher CVD risk than either component alone. RESEARCH DESIGN AND METHODS The Australian Diabetes, Obesity and Lifestyle (AusDiab) study included 11,247 adults aged ≥25 years from 42 randomly selected areas of Australia. At baseline (1999–2000), diabetes status was defined using the World Health Organization criteria and HRF was assessed using the SF-36 questionnaire. RESULTS Overall, after 7.4 years of follow-up, 57 persons with diabetes and 105 without diabetes had died from CVD. In individuals with and without diabetes, HRF measures were significant predictors of increased CVD mortality. The CVD mortality risks among those with diabetes or impaired physical health component summary (PCS) alone were similar (diabetes only: hazard ratio 1.4 [95% CI 0.7–2.7]; impaired PCS alone: 1.5 [1.0–2.4]), while those with both diabetes and impaired PCS had a much higher CVD mortality (2.8 [1.6–4.7]) compared with those without diabetes and normal PCS (after adjustment for multiple covariates). Similar results were found for the mental health component summary. CONCLUSIONS This study demonstrates that the combination of diabetes and impaired HRF is associated with substantially higher CVD mortality. This suggests that, among those with diabetes, impaired HRF is likely to be important in the identification of individuals at increased risk of CVD mortality.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Risk of Cardiovascular and All-Cause Mortality: Impact of Impaired Health-Related Functioning and Diabetes

et al. 2012

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“…This association between diabetes and complications means that people with diabetes not only have shorter life expectancy than people without diabetes [8,9], but also experience poorer health-related quality of life (HRQoL) than the general population [10,11,12]. Moreover, patients with diabetes-related complications have lower HRQoL than diabetes patients without complications [13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Health Utilities of Type 2 Diabetes-Related Complications: A Cross-Sectional Study in Sweden

Kiadaliri

Gerdtham

Eliasson

et al. 2014

IJERPH

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This study estimates health utilities (HU) in Sweden for a range of type 2 diabetes-related complications using EQ-5D and two alternative tariffs (UK and Swedish) from 1757 patients with type 2 diabetes from the Swedish National Diabetes Register (NDR). Ordinary least squares were used for statistical analysis. Lower HU was found for female gender, younger age at diagnosis, higher BMI, and history of complications. Microvascular and macrovascular complications had the most negative effect on HU among women and men, respectively. The greatest decline in HU was associated with kidney disorders (−0.114) using the UK tariff and stroke (−0.059) using the Swedish tariff. Multiple stroke and non-acute ischaemic heart disease had higher negative effect than a single event. With the UK tariff, each year elapsed since the last microvascular/macrovascular complication was associated with 0.013 and 0.007 units higher HU, respectively. We found important heterogeneities in effects of complications on HU in terms of gender, multiple event, and time. The Swedish tariff gave smaller estimates and so may result in less cost-effective interventions than the UK tariff. These results suggest that incorporating subgroup-specific HU in cost-utility analyses might provide more insight for informed decision-making.

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“…Recent interest in quality of life (QOL) as an outcome measure in medicine has inspired studies in chronic medical1–3 and general population subjects45 in Arab and neighboring countries. To further this interest, it is important to use assessment instruments that are psychometrically sound and have cross-cultural validity, so as to make findings comparable across countries.…”

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confidence: 99%

The reliability and validity of the short version of the WHO Quality of Life Instrument in an Arab general population

Ohaeri¹,

Awadalla

2009

Annals of Saudi Medicine

169

144

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BACKGROUND AND OBJECTIVES:There is rising interest in quality of life (QOL) research in Arabian countries. The aim of this study was to assess in a nationwide sample of Kuwaiti subjects the reliability and validity of the World Health Organization Quality of Life (WHOQOL-BREF), a shorter version of the widely used QOL assessment instrument that comprises 26 items in the domains of physical health, psychological health, social relationships, and the environment.METHODS:A one-in-three systematic random proportionate sample of consenting Kuwaiti nationals attending large cooperative stores and municipal government offices in the six governorates completed the Arabic translation of the questionnaire. The indices assessed included test-retest reliability, internal consistency, item internal consistency (IIC), item discriminant validity (IDV), known-groups and construct validity.RESULTS:There were 3303 participants (44.8% males, 55.2% females, mean age 35.4 years, range 16 to 87 years). The intra-class correlation for the test-retest statistic and the internal consistency values for the full questionnaire and the domains had a Cronbach's alpha≥0.7. Of the 24 items that constitute the domains, 21 met the IIC requirement of correlation ≥0.4 with the corresponding domain, while 16 met the IDV criterion of having a higher correlation with their corresponding domain than other domains. Domain scores discriminated significantly between well and sick groups. In the factor analysis, four strong factors emerged with the same construct as in the WHO report.CONCLUSION:The Arabic translation of the WHOQOL-BREF has impressive reliability and validity indices. The poor IDV findings are due to the multidimensional nature of the questionnaire. The highly significant validity indices should reassure researchers that the questionnaire represents the same constructs across cultures. Negatively worded items possibly need refinement.

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Health-related quality of life in type 2 diabetic patients

Cited by 47 publications

References 18 publications

Risk of Cardiovascular and All-Cause Mortality: Impact of Impaired Health-Related Functioning and Diabetes

Risk of Cardiovascular and All-Cause Mortality: Impact of Impaired Health-Related Functioning and Diabetes

Health Utilities of Type 2 Diabetes-Related Complications: A Cross-Sectional Study in Sweden

The reliability and validity of the short version of the WHO Quality of Life Instrument in an Arab general population

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