Health-related quality of life in meningioma

Abstract

Meningiomas are the most common primary intracranial tumor in adults. Although frequently histologically benign, the clinical severity of a lesion may range from being asymptomatic to causing severe impairment of global function and well-being. The diversity of intracranial locations and clinical phenotypes poses a challenge when studying functional impairments, however, more recent attention to patient-reported outcomes and health-related quality of life (HRQOL) have helped to improve our understanding of how meningioma may impact a patient’s life. Treatment strategies such as observation, surgery, radiation, or a combination thereof have been examined to ascertain their contributions to symptoms, physical and cognitive functioning, disability, and general aspects of daily functioning. This review explores the multidimensional nature of HRQOL and how patients may be influenced by meningiomas and their treatment. Overall, treatment of symptomatic meningiomas is associated with improved HRQOL, cognitive functioning, and seizure control while tumor size, location, histologic grade, and epileptic burden are associated with worse HRQOL.

Meningiomas with CNS invasion

“…Although meningiomas do not always cause neurological deficits or other symptoms, patients with meningiomas demonstrate significant impaired quality of life compared to normative healthy controls even before surgery (van Nieuwenhuizen et al, 2013;Haider et al, 2021). This may be partially attributed to disease-related stress, when a patient realizes that he or she has got a brain tumour, or to preoperative anxiety (Wagner et al, 2019;Haider et al, 2021).…”

“…Although meningiomas do not always cause neurological deficits or other symptoms, patients with meningiomas demonstrate significant impaired quality of life compared to normative healthy controls even before surgery (van Nieuwenhuizen et al, 2013;Haider et al, 2021). This may be partially attributed to disease-related stress, when a patient realizes that he or she has got a brain tumour, or to preoperative anxiety (Wagner et al, 2019;Haider et al, 2021). Jakola et al (2012) prospectively evaluated a cohort of 54 patients with meningiomas and found an improvement of the cases' health related quality of life (HRQOL) after surgery, which was mainly due to relief from anxiety.…”

“…10. 3389/fnins.2023.1189606 Frontiers in Neuroscience 08 frontiersin.org (Ehresman et al, 2019;Maschke et al, 2019;Przybylowski et al, 2020;Haider et al, 2021;Starnoni et al, 2021). The role of the degree of resection has been controversially discussed.…”

Differences in Hearing, Balance, and Quality-of-Life Outcomes in Petroclival Versus Nonpetroclival Posterior Fossa Meningiomas

“…Overall health-related quality of life tends to improve in meningioma patients after treatment, regardless of modality (11). Studies have shown that degree of improvement is often related to severity of symptoms before treatment (12).…”

Malignant meningioma

“…Studies exploring quality of life and everyday life from a patient perspective in patients with WHO grade 3 meningioma are non‐existing. In meningioma, irrespective of grade, recent studies found a long‐term reduction in health‐related quality of life, 103,104 elevated use of anti‐depressants even two years after surgery, 54 and a high burden of socioeconomic difficulties after meningioma surgery 105 . Moreover, patients with meningioma experienced a lack of support in the postoperative phase for optimal recovery 106 and could experience a paradox when they had to undergo extensive surgery for a benign tumour 107 .…”