Health-related quality of life in curatively-treated patients with esophageal or gastric cancer: A systematic review and meta-analysis

Boorn, Héctor G. van den; Stroes, Charlotte I.; Zwinderman, Aeilko H.; Eshuis, Wietse J.; Hulshof, Maarten C.C.M.; Etten-Jamaludin, Faridi S. van; Sprangers, Mirjam A. G.; Laarhoven, H.W.M. van

doi:10.1016/j.critrevonc.2020.103069

Cited by 34 publications

(29 citation statements)

References 93 publications

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“…As expected, pain and dysphagia scores were higher postoperatively and also returned to baseline at six months. These results are in line with a recent meta-analysis by van den Boorn et al that showed that the largest decline in global health status was seen in the first month after gastrectomy and twelve months after surgery global health status returned to baseline [15].…”

Section: Discussionsupporting

confidence: 92%

Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial

Wielen¹,

Daams²,

Rosati³

et al. 2022

European Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 92%

Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial

Wielen¹,

Daams²,

Rosati³

et al. 2022

European Journal of Surgical Oncology

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“…Most studies evaluating HRQOL in gastric cancer patients focus on the impact of surgery alone. Deterioration of HRQOL after a gastrectomy has been described [ 14 , 15 ]. However, the impact on HRQOL of current curative treatment strategies is still unclear [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Deterioration of HRQOL after a gastrectomy has been described [ 14 , 15 ]. However, the impact on HRQOL of current curative treatment strategies is still unclear [ 14 , 15 ]. These considerations prompted us to conduct this systematic review.…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life in Locally Advanced Gastric Cancer: A Systematic Review

Amelsfoort

Sluis

Schats

et al. 2021

Cancers

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Background: Current treatment strategies have been designed to improve survival in locally advanced gastric cancer patients. Besides its impact on survival, treatment also affects health-related quality of life (HRQOL), but an overview of reported studies is currently lacking. The aim of this systematic review was therefore to determine the short- and long-term impact of chemotherapy, surgery, and (chemo)radiotherapy on HRQOL in locally advanced, non-metastatic gastric cancer patients. Methods: A systematic review was performed including studies published between January 2000 and February 2021. We extracted studies published in Medline, Embase, and Scopus databases that assessed HRQOL in patients with locally advanced, non-metastatic gastric cancer treated with curative intent. Studies using non-validated HRQOL questionnaires were excluded. Short-term and long-term HRQOL were defined as HRQOL scores within and beyond 6 months after treatment, respectively. Results: Initially, we identified 8705 articles (4037 of which were duplicates, i.e., 46%) and ultimately included 10 articles. Most studies reported that short-term HRQOL worsened in the follow-up period from 6 weeks to 3 months after surgery. However, recovery of HRQOL to preoperative levels occurred after 6 months. After completion of chemoradiotherapy, the same pattern was seen with worse HRQOL after treatment and a recovery of HRQOL after 6–12 months. Conclusions: In patients with locally advanced, non-metastatic gastric cancer, HRQOL deteriorated during the first 3 months after surgery and chemoradiotherapy. However, the long-term data showed a recovery of HRQOL after 6–12 months. To implement HRQOL in clinical decision making in current clinical practice, more research is needed.

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“…The survival models are based on the 2020 version of the models, which include updated palliative prediction models and newly developed curative prediction models for both esophageal and gastric cancer [ 39 ]. The HRQoL model for curatively treated patients originates from a systematic review and meta-analysis, and treatment side effects for curatively treated patients were provided by the COMplot study [ 82 , 83 ]. The addition of these models to the Source tool enables evidence-based and precise information personalized to the individual’s characteristics in the full spectrum of patients with esophagogastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Informing Patients With Esophagogastric Cancer About Treatment Outcomes by Using a Web-Based Tool and Training: Development and Evaluation Study

et al. 2021

Self Cite

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Background Due to the increasing use of shared decision-making, patients with esophagogastric cancer play an increasingly important role in the decision-making process. To be able to make well-informed decisions, patients need to be adequately informed about treatment options and their outcomes, namely survival, side effects or complications, and health-related quality of life. Web-based tools and training programs can aid physicians in this complex task. However, to date, none of these instruments are available for use in informing patients with esophagogastric cancer about treatment outcomes. Objective This study aims to develop and evaluate the feasibility of using a web-based prediction tool and supporting communication skills training to improve how physicians inform patients with esophagogastric cancer about treatment outcomes. By improving the provision of treatment outcome information, we aim to stimulate the use of information that is evidence-based, precise, and personalized to patient and tumor characteristics and is communicated in a way that is tailored to individual information needs. Methods We designed a web-based, physician-assisted prediction tool—Source—to be used during consultations by using an iterative, user-centered approach. The accompanying communication skills training was developed based on specific learning objectives, literature, and expert opinions. The Source tool was tested in several rounds—a face-to-face focus group with 6 patients and survivors, semistructured interviews with 5 patients, think-aloud sessions with 3 medical oncologists, and interviews with 6 field experts. In a final pilot study, the Source tool and training were tested as a combined intervention by 5 medical oncology fellows and 3 esophagogastric outpatients. Results The Source tool contains personalized prediction models and data from meta-analyses regarding survival, treatment side effects and complications, and health-related quality of life. The treatment outcomes were visualized in a patient-friendly manner by using pictographs and bar and line graphs. The communication skills training consisted of blended learning for clinicians comprising e-learning and 2 face-to-face sessions. Adjustments to improve both training and the Source tool were made according to feedback from all testing rounds. Conclusions The Source tool and training could play an important role in informing patients with esophagogastric cancer about treatment outcomes in an evidence-based, precise, personalized, and tailored manner. The preliminary evaluation results are promising and provide valuable input for the further development and testing of both elements. However, the remaining uncertainty about treatment outcomes in patients and established habits in doctors, in addition to the varying trust in the prediction models, might influence the effectiveness of the tool and training in daily practice. We are currently conducting a multicenter clinical trial to investigate the impact that the combined tool and training have on the provision of information in the context of treatment decision-making.

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Health-related quality of life in curatively-treated patients with esophageal or gastric cancer: A systematic review and meta-analysis

Cited by 34 publications

References 93 publications

Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial

Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial

Health-Related Quality of Life in Locally Advanced Gastric Cancer: A Systematic Review

Informing Patients With Esophagogastric Cancer About Treatment Outcomes by Using a Web-Based Tool and Training: Development and Evaluation Study

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