Health-related quality of life in patients with ANCA vasculitides compared to rheumatoid arthritis: a cross-sectional comparative study

Παναγιωτόπουλος, Αλέξανδρος; Thomas, Konstantinos; Argyriou, Evangelia; Chalkia, Aglaia; Kapsala, Noemin; Koutsianas, Christos; Mavrea, Evgenia; Petras, Dimitrios; Boumpas, Dimitrios T.; Vassilopoulos, Dimitrios

doi:10.1093/rheumatology/kead214

Cited by 4 publications

(2 citation statements)

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“…We found that most of the deaths had high VDI at 24 months (Table S1). Previous studies showed that the progression of VDI associated not only with survival of AAV patients but also with decrease in quality of life 4,26,27 . Our AAV patients were evaluated by the ECOG‐PS (performance status), a assessment tool for the physical activity of cancer patients on a 5‐point scale 23 .…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies showed that the progression VDI associated not only with survival of AAV patients but also with decrease in quality of life. 4,26,27 Our AAV patients were evaluated by the ECOG-PS (performance status), a tool for the physical activity of cancer patients on a 5-point scale. 23 When the patients were divided into four groups based on VDI at 24 months, VDI progression at 24 months closely associated with ECOG-PS at 24 months (Figure 3E).…”

Section: Vdi Contribute To the Physical Activities And Survivals Of A...mentioning

confidence: 99%

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Recent advances in the treatment strategy for AAV improved outcomes with intensive GC tapering

Ono,

Kai,

Takeyama

et al. 2023

Int J of Rheum Dis

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ObjectiveTo evaluate trends in results of care and management for antineutrophil cytoplasmic antibodies (ANCA)‐associated vasculitis (AAV).MethodsWe employed multicenter cohort data collected during 2011–2021, recruiting 43 patients with granulomatosis with polyangiitis (GPA) and 91 with microscopic polyangiitis (MPA). According to the median registration date of September 2015, patients have split into two groups: an early group and a late group (both of them, n = 67). To prevent bias, a propensity score according to numerous baseline characteristics variables was calculated; 50 matching members of each group were statistically extracted. Their treatments and clinical outcomes were examined at 6, 12, and 24 months after initial remission therapy.ResultsStatistics demonstrated that the baseline characteristics were similar. The late group used rituximab (RTX) more often for both remission induction and maintenance therapy, compared with the early group. The mean daily PSL doses of the late group were significantly lower than those of early group at each time point. The late group discontinued PSL 14.0% at 12 months and 23.3% at 24 months. Despite their intensive glucocorticoids (GC) tapering, the remission rates and the relapse rates were significantly fairer in the late group. The Vasculitis Damage Index (VDI) and VDI due to GC at each time point were lower in the late group, and those differences had become wider over time.ConclusionRecent developments in AAV treatment have allowed efficient remission and prevention of relapses, which in turn enabled extensive GC tapering causing fewer sequelae.

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Section: Resultsmentioning

confidence: 99%

Section: Vdi Contribute To the Physical Activities And Survivals Of A...mentioning

confidence: 99%

Recent advances in the treatment strategy for AAV improved outcomes with intensive GC tapering

Ono,

Kai,

Takeyama

et al. 2023

Int J of Rheum Dis

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Construction of College Students’ Mental Health Evaluation System Based on Cluster Analysis Algorithm

Guo,

Hong

2024

Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering

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How is the patient perspective captured in ANCA-associated vasculitis research? An integrative review

Granath,

Pettersson,

Gunnarsson

et al. 2023

Rheumatology Advances in Practice

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Objective The aim was to describe how the patient perspective is captured in clinical research of ANCA-associated vasculitis (AAV). Methods This integrative review included 2149 publications found in four different databases and manual searches. After screening, 156 articles remained. All articles were sorted and categorised, and 77 original articles were further analysed. Results The patient perspective was captured with patient-reported outcome measures (PROMs), single-item questionnaires, project-specific questionnaires, and interviews. The most common aspects measured were health-related quality of life, anxiety and depression, and fatigue, while the least common were lifestyle habits, relationships, and self-management. Conclusion The patient perspective was captured predominantly with generic PROMs, and occasionally with a qualitative approach. AVV is a lifelong disease, and the results from this review show that not all aspects of importance to patients are covered with the PROMs used in research. Future studies should include the areas that are the most important for patients. LAY SUMMARY What does this mean for patients? People living with ANCA-associated vasculitis (AAV) can be affected by the disease in different ways and can experience several symptoms that affect everyday life. We have studied how the patient perspective has been captured in research investigating AAV. We investigated what part of a patient’s experience had been included in the research and how that was captured. After looking at 156 different articles about AAV from 1997 until 2023, we found that the patient perspective was mostly captured through questionnaires evaluating quality of life, or anxiety and depression. Less common were questionnaires that assessed lifestyle habits or relationships. Interview studies were not often used. We noticed that the parts of living with AVV, such as airway problems, problems related to medication and side effects, and concerns about the future, were seldom included in the research. This study adds to our understanding of how the patient experience of AAV is investigated in research. Our results give researchers insight into which measurements are commonly used in research, as well as areas that have not been included in research and should be investigated further. There is lack of studies that use interviews to ask patients about their experiences of living with AAV.

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Health-related quality of life in patients with ANCA vasculitides compared to rheumatoid arthritis: a cross-sectional comparative study

Cited by 4 publications

References 40 publications

Recent advances in the treatment strategy for AAV improved outcomes with intensive GC tapering

Recent advances in the treatment strategy for AAV improved outcomes with intensive GC tapering

Construction of College Students’ Mental Health Evaluation System Based on Cluster Analysis Algorithm

How is the patient perspective captured in ANCA-associated vasculitis research? An integrative review

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