Health-Related Quality of Life in Patients with Ankylosing Spondylitis: Relationship with Disease-Related Variables

Abstract

Background: Ankylosing spondylitis (AS) is a chronic progressive inflammatory disease leading to functional limitations and subsequently impaired quality of life (QoL). Despite the fact that QoL was recognized as a significant perception, it was excluded from the core domains (defined by the Assessment of Spondyloarthritis International Society), because of the ambiguity of measurement choice. Aim: To assess QoL in patients with AS using a generic; Short Form-36 (SF-36) and a disease-specific; Ankylosing Spondylitis quality of life (ASQoL) instruments and to explore its relationship to the clinical characteristics, disease activity, functional status, and radiographic severity. Methods: A total of 47 AS patients who fulfilled modified New York criteria were included. Disease activity, functional status, spinal mobility, and radiographic severity were assessed by Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), Bath AS Metrology Index (BASMI) and Bath AS Radiology Index (BASRI) respectively. SF-36 and ASQoL instruments evaluated QoL. Results: Physical health was more affected especially in patients with peripheral arthritis by SF-36 (p=0.008) and ASQoL (p=0.022) scores. Both SF-36 total and ASQoL scores correlated significantly with BASDAI (r = -0.329, p = 0.024 and r = 0.420, p = 0.003), BASFI (r = -0.399, p = 0.005 and r = 0.513, p=0.001) and BASMI (r = -0.382, p = 0.008 and r = 0.482, p= 0.001) respectively. Conclusion: QoL was impaired in AS patients with the highest impact on physical health especially in association with peripheral arthritis. SF-36 and ASQol have a comparable achievement in the evaluation of QoL in AS patients and both physical function and spinal mobility were identified as predictors of poor QoL.

Life quality of men with ankylosing spondylitis: association with the disease course and the structural and functional state of bone tissue

“…We have demonstrated that the group of patients with a peripheral form of disease tended to have reduced life quality indices compared with those of patients with a central AS form, by the SF-36 (PCS; MCS) and HAQ. Similar results were registered by G. Elolemy et al (2020): patients with a peripheral form of disease had a worse life quality than those with a central AS form in terms of the physical component [3]. However, W. Hamdi et al (2012) did not find any associations with a form of disease [18].…”

“…However, they are significantly worse in subjects with the Vitamin D deficiency, a high dose of glucocorticoids and high disease activity. http://pjs.zaslavsky.com.ua Оригінальні дослідження / Original Researches life quality compared to the general population; however, the patients with comorbidities register an even more reduced one [2,3]. In particular, according to Shevchuk S. et al (2020), the life quality evaluated by the SF-36 and HAQ questionnaires was significantly lower in the AS patients with an anemic syndrome than in the patients with no anemia present [4].…”

Inhibiting IL-17A and IL-17F in Rheumatic Disease: Therapeutics Help to Elucidate Disease Mechanisms

“…Ankylosing spondylitis can negatively impact the patient's quality of life [78,79]. In addition to objective measures of disease control, there are various patient-reported outcomes (PROs) that measure subjective improvements in the disease process.…”

Measuring Outcomes in Axial Spondyloarthritis

“…Construct validity has been demonstrated because the ASQoL correlates with the BASDAI (0.42), BASFI (0.51), and Bath Ankylosing Spondylitis Metrology Index (BASMI) (0.48) (95). The ASQoL is also correlated with the Jenkins Sleep Scale (96).…”