Health-related quality of life in high-grade glioma patients: a prospective single-center study

Yavaş, Çağdaş; Zorlu, Faruk; Özyiğit, Gökhan; Gurkaynak, M.; Yavaş, Güler; Yüce, Deniz; Cengiz, Mustafa; Yıldız, Ferah; Akyol, Fadıl

doi:10.1007/s00520-011-1340-4

Cited by 51 publications

(62 citation statements)

References 39 publications

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“…The literature has identified differences in levels of anxiety, depression and HRQOL with respect to gender [68], age and KPS [10], while the role of tumor localisation is inconclusive [69][70][71]. Our study examined a limited number of relationships.…”

Section: Study Limitationsmentioning

confidence: 99%

Health-related quality of life in patients with high-grade gliomas: a quantitative longitudinal study

et al. 2015

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The diagnosis of a high-grade glioma usual is followed by functional impairment(s), cognitive decline and an impaired psycho-social well-being. This might well have a significant and negative impact on the health related quality of life. The purpose of this study was to explore physical activity levels, prevalence and severity of anxiety and depressive symptoms and health-related quality of life among patients with a highgrade glioma. This paper is based on a longitudinal mixed methods study. Patients (n = 30) completed questionnaires at 5 time points from time of diagnosis until the final follow-up after 1 year. Scores of Karnofsky Performance Status (KPS), physical activity, anxiety and depression and health-related quality of life (FACT-Br) are obtained. Patients' physical activity level and KPS decrease during the disease- and treatment trajectory. The majority of patients did not report any depressive symptoms, eight individuals (26.7 %) being depressed at various time points. Among a sub-group of participants who completed all study requirements for the entire study period the level of anxiety decreased significantly during the study. The FACT-Br sub-scale of emotional well-being increased significant, indicating a better HRQOL attend of followup. The diagnosis of a HGG leads to an ongoing functional decline measured as a decline of the KPS and a reduced physical activity during leisure time. Supportive care combined with rehabilitative and palliative approaches might well be valuable along the trajectory especially during the post-surgery period when anxiety is at its highest peak.

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Section: Study Limitationsmentioning

confidence: 99%

Health-related quality of life in patients with high-grade gliomas: a quantitative longitudinal study

et al. 2015

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“…45 However, that study by Yavas et al excluded patients with KPS < 70, and baseline HRQoL was assessed after surgery. The latter is important as we demonstrate that surgery is the therapy most likely to induce sudden significant positive or negative changes in HRQoL.…”

Section: Deterioration In Hrqol After Tumor Progressionmentioning

confidence: 99%

“…Also, there are often strict inclusion criteria as part of oncological clinical trials, and patients with cognitive impairment 8 or patients with KPS scores less than 70 5,45 are often excluded. In the present study, we attempted to overcome these limitations.…”

Section: Strengths and Weaknessesmentioning

confidence: 99%

Quality of survival the 1st year with glioblastoma: a longitudinal study of patient-reported quality of life

Sagberg

Solheim

Jakola

2016

JNS

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OBJECT By exploring longitudinal patient-reported health-related quality of life (HRQoL), the authors sought to assess the quality of survival for patients in the 1st year after diagnosis of glioblastoma. METHODS Thirty unselected patients ≥ 18 years who underwent primary surgery for glioblastoma in the period 2011–2013 were included. Using the generic HRQoL questionnaire EQ-5D 3L, baseline HRQoL was assessed before surgery and at postoperative follow-up after 1, 2, 4, 6, 8, 10, and 12 months. RESULTS There was an apparent correlation between deterioration in HRQoL scores and tumor progression. Patients with permanent deterioration in HRQoL early after surgery represented a subgroup with rapid progression and short survival. Both positive and negative changes in HRQoL were more often seen after surgery than after radio- or chemotherapy. Patients with gross-total resection (GTR) reported better and more stable HRQoL. In a multivariable analysis preoperative cognitive symptoms (p = 0.02), preoperative functional status (p = 0.03), and GTR (p = 0.01) were independent predictors of quality of survival (area under the curve for EQ-5D 3L index values). CONCLUSIONS The results indicate that progression-free survival is not only a surrogate marker for survival, but also for quality of survival. Quality of survival seems to be associated with GTR, which adds further support for opting for extensive resections in glioblastoma patients with good preoperative functional levels.

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“…Qualitative work told a story of suffering and struggle [40] in keeping with several quantitative studies which reported significant burdens particularly in psychosocial domains [37,38,44]. Other studies however found that self-reported quality of life was largely unaffected despite significant impairments in neuro-cognitive and functional domains [34,36,41,42].…”

Section: Patient Views Of Selfmentioning

confidence: 77%

“…Used as a means of coping, this phenomenon may contribute to positive quality of life assessments by patients in the face of poor functional health and well-being. [7, 34, 36-38, 41, 42, 44] Suffering and struggle persists amid multiple losses and future uncertainty [34,36,40] Anxiety, depression and distress are prevalent, particularly in the setting of disease progression, recurrence or poor functional outcomes [35][36][37][38][39]44] Neurocognitive and psychosocial deficits are perceived as more severe than patients' self-report [35,40] Patient quality of life is perceived as worse than caregiver quality of life [43] Caregiving is an ambiguous, relentless, exhausting task [40,43] Suffering and struggle persists amid multiple losses and future uncertainty [40] Caregiver quality of life is negatively impacted by poor patient neurocognitive and psychosocial function [43] Anxiety and depression are prevalent among caregivers [35,43] Caregiver anxiety may be independent of patient functional status [35] Caregivers have limited time for self-care and receive minimal external supports [43] J Neurooncol (2014) 120:1- 10 7 The two longitudinal studies found self-reported quality of life decreased with tumour recurrence and disease progression rather than duration of disease [34,44], although Lovely et al [40] found qualitative evidence that symptoms are progressive even in the absence of recurrence possibly due to late effects of treatment. Keir et al [39] showed that high rates of distress persist as patients transition into survivorship.…”

Section: Patient Views Of Selfmentioning

confidence: 99%

Living longer with adult high-grade glioma:setting a research agenda for patients and their caregivers

et al. 2014

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The long-term survival of patients with adult high-grade glioma (HGG) remains poor, but for those who do live longer functional status and neurocognitive ability may be influenced by residual or recurrent tumour, or treatment-related complications. The aim of this review was to examine the current literature regarding the quality of life and experience of patients living longer with adult HGG and their caregivers, with a view to understanding the burden of treatment on patient abilities and deficits over time. Medline, PsychINFO and CINAHL databases were searched for the core concept of HGG in combination with an aspect of quality of long-term survival. Key findings of the 12 included studies were identified and synthesised thematically. There is a paucity of dedicated studies which have investigated the experiences of this cohort. The strength of existing literature is limited by the systematic exclusion of the poorest functioning patients and the under-representation of caregiver perspectives. Discrepancies in how patients view their quality of life were highlighted, despite consistent findings of significant physical and functional impairment. This review confirmed the presence of important differences between patient and caregiver views regarding patient abilities following treatment. Caregiver burden was found to be high, due to multiple dynamic and relentless stressors. The true experience of patients living longer with adult HGG and their caregivers remains unclear, particularly for patients with poorer neurocognitive and functional outcomes. Further research is required to clarify and replicate findings, explore discrepancies between patient and caregiver views, and to specifically investigate how caregiver needs and experiences may evolve over time.

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Health-related quality of life in high-grade glioma patients: a prospective single-center study

Abstract: We conclude that there were many changes in patients with high-grade glioma during the course of the disease and most of them were related to disease progression.

Cited by 51 publications

References 39 publications

Health-related quality of life in patients with high-grade gliomas: a quantitative longitudinal study

Health-related quality of life in patients with high-grade gliomas: a quantitative longitudinal study

Quality of survival the 1st year with glioblastoma: a longitudinal study of patient-reported quality of life

Living longer with adult high-grade glioma:setting a research agenda for patients and their caregivers

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