“…Based on data from NHANES III and the Framingham Osteoarthritis Study, the prevalence of knee osteoarthritis in the United States is estimated to be 14% in adults 26 years of age or older, 19% in those 45 years of age or older, 37% in those 60 years of age or older, and 44% in those over 80 years of age (Dillon et al, 2006;Felson et al, 1987;Lawrence et al, 2008). Osteoarthritis can have a negative impact on health-related quality of life and psychological well-being (Axford et al, 2008;Breedveld, 2004;de Bock et al, 1995;Jinks et al, 2007;Majani et al, 2005;Salaffi et al, 2005). Patients with osteoarthritis are often limited in their ability to participate in main daily activities (eg, household duties, employment, body care, ambulation, and sleep) and to maintain their independence (de Bock et al, 1995;Jinks et al, 2007;Segal et al, 2004).…”