Health‐related quality of life in children and adolescents with stroke, self‐reports, and parent/proxies reports: Cross‐sectional investigation

Neuner, Bruno; Mackensen, Sylvia von; Krümpel, Anne; Manner, Daniela; Friefeld, Sharon; Nixdorf, Sarah; Frühwald, Michael C.; deVeber, Gabrielle; Nowak‐Göttl, Ulrike

doi:10.1002/ana.22381

Cited by 65 publications

(77 citation statements)

References 35 publications

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“…Studies found that younger age at stroke onset was significantly associated with poorer QoL in the domains of physical functioning and neurological outcome [13], long-term clinical outcomes and independence in daily activities [44,46], adaptive functioning skills [47], and overall outcome [16]. In contrast, younger age at stroke was associated with better overall well-being and quality of life [20] and better self-rated self-esteem and social participation [21] in other studies. Older age at stroke was associated with more behavioural difficulties in another study [29].…”

Section: Factors Associated With Psychosocial Outcomementioning

confidence: 97%

“…Twenty-six studies did not recruit a control group but compared scores to published normative population data. Of the remaining ten that did recruit control participants, these included typically developing children as controls [20,8,21]; children with other non-neurological health conditions, such as orthopaedic and chronic asthma controls [22,23,24,25,26,21,8]; and some children with other neurodevelopmental conditions but without stroke, such as sickle cell disease controls [27] or malformations of cortical development [28]. The participant sample sizes in the studies ranged from fourteen children [28] to 163 children [2].…”

Section: Insert Figure 1 About Herementioning

confidence: 99%

“…Seventeen studies attempted to assess quality of life in children with stroke, using both unstandardized and standardized measures [13,39,17,20,30 …”

Section: Quality Of Lifementioning

confidence: 99%

“…Children with stroke onset under two years of age had significantly lower physical function ratings than those with stroke onset over two years of age [13] Neuner et al [20] showed that younger age at stroke was associated with better overall well-being and QOL. They also found that neurological severity was a significant predictor of poorer overall well-being.…”

Section: Predictors Of Hrqolmentioning

confidence: 99%

“…Health-related QoL (HRQoL) has been described as "A psychological construct which describes the physical, mental, social, psychological and functional aspects of well-being and function from a patient perspective" [19]. However, studies exploring the impact on a child's QOL following a stroke have been limited and there has been a call for further research in this area [12,20,3].…”

Section: Introductionmentioning

confidence: 99%

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Psychosocial outcome and quality of life following childhood stroke – A systematic review

O’Keeffe

Stark

Murphy

et al. 2017

Developmental Neurorehabilitation

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Objectives. The aim of this paper was to critically review the recent literature on psychosocial and behavioural outcome following childhood stroke, to assess whether quality of life is affected and to investigate the factors related to psychosocial outcome.Methods. Literature searches were conducted and identified 36 relevant papers from the period 1908-2016.Results. The systematic review found that many children experience difficulties in a wide range of psychosocial domains. Quality of life can also be significantly reduced. Inconsistent findings regarding the correlates of outcome are likely due to methodological limitations. These issues include small and heterogeneous samples, lack of control groups and measurement difficulties.Conclusions. This systematic review strongly indicates that childhood stroke can affect a myriad of psychosocial domains and a child's quality of life.Methodological issues, particularly around heterogeneous samples and measures, limit the conclusions that can be drawn regarding the predictors of outcome.

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Section: Factors Associated With Psychosocial Outcomementioning

confidence: 97%

Section: Insert Figure 1 About Herementioning

confidence: 99%

“…Seventeen studies attempted to assess quality of life in children with stroke, using both unstandardized and standardized measures [13,39,17,20,30 …”

Section: Quality Of Lifementioning

confidence: 99%

Section: Predictors Of Hrqolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychosocial outcome and quality of life following childhood stroke – A systematic review

O’Keeffe

Stark

Murphy

et al. 2017

Developmental Neurorehabilitation

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Role of reduced ADAMTS13 in arterial ischemic stroke: A Pediatric Cohort Study

Lambers

Goldenberg

Kenet

et al. 2012

Annals of Neurology

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Objective Previous studies in adults and mice have implicated ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), also known as von Willebrand factor (VWF)-cleaving protease, as a protective factor for stroke. Here we investigated ADAMTS13 in 208 pediatric patients with arterial ischemic stroke (AIS) and 125 population-based control children in a frequency-matched case–control study. Methods The proportion of patients/controls with ADAMTS13 activity levels below and above the 10th percentile was compared. Additionally, in a quintile comparison, the proportion of patients versus controls in the lowest ADAMTS13 quintile was compared to those in the 2nd to 5th quintiles. Adjustment was performed for VWF antigen (VWF:Ag), factor VIII activity (FVIII:C), blood group, and age. Results Forty-six of 208 patients (22%) showed ADAMTS13 levels below the 10th percentile, compared with 5 of 125 controls (4%; p < 0.001). Odds ratios/95% confidence intervals were 7.30/2.73–19.50 for the lowest percentile and 2.44/1.15–5.16 in the quintile comparison after adjustment for VWF:Ag, FVIII:C, blood group, and age. Comparing the proportion of patients with ADAMTS13 activity below the 10th percentile within the different stroke subtypes (undetermined, cardioembolic, steno-occlusive arteriopathies), no statistically significant differences were found (undetermined, 16 of 89; cardioembolic, 6 of 40; steno-occlusive arteriopathies, 24 of 79; p = 0.08). ADAMTS13 levels did not significantly differ among stroke subtypes (p = 0.29). Interpretation Our findings implicate reduced ADAMTS13 activity as a risk factor for pediatric AIS, and support the concept that ADAMTS13 has a role in the pathogenesis of pediatric AIS.

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Neurovaskuläre Erkrankungen inklusive Schlaganfall

Steinlin

Studer

2023

Transition Bei Neurologischen Erkrankungen

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Health‐related quality of life in children and adolescents with stroke, self‐reports, and parent/proxies reports: Cross‐sectional investigation

Abstract: Pediatric stroke survivors compared with healthy controls are strongly affected regarding their overall well-being and older children/adolescents regarding their well-being with peers.

Cited by 65 publications

References 35 publications

Psychosocial outcome and quality of life following childhood stroke – A systematic review

Psychosocial outcome and quality of life following childhood stroke – A systematic review

Role of reduced ADAMTS13 in arterial ischemic stroke: A Pediatric Cohort Study

Neurovaskuläre Erkrankungen inklusive Schlaganfall

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