Health-related quality of life in pediatric and adolescent patients with transfusion-dependent ß-thalassemia in upper Egypt (single center study)

Abstract

BackgroundThalassemia is a major health problem that disturbs the lifestyle of the affected patient. The aim of this work is to detect the impact of thalassemia on the quality of life regarding physical, social, emotional, psychological scored assessment.MethodsA case-control survey was conducted in Minia University children’s hospital on 64 patients recruiting pediatric hematology outpatient clinic from July 2014 to February 2017. PedsQL™ 4.0 Generic Core Scale (Arabic version) was used to assess HRQOL in 64 thalassemia patients between 8 and 18 years of ages. Other related clinical data of the involved patients were collected from the pediatric hematology records.ResultsMean physical, emotional, social, school performance, psychological and total scores (− 36.9 ± 20.9, 49.4 ± 17, 47.2 ± 21.3, 38.5 ± 15.5, 45.3 ± 13.8, 47.9 ± 38.8 respectively) were significantly decreased compared with control (p = 0.001 for all). The younger age group had better scores regarding social, emotional, psychological and total scores compared to older ones (p = 0.01, 0.03, 0.01 and 0.009 respectively). Older age of starting transfusion was statistically significant protecting factor from poor physical QOL in thalassemia patients (OR = 0.96, p = 0.03). The presence of hepatomegaly was a statistically significant predictor for poor physical QOL (OR = 8.5, p = 0.02). Household income was the statistically significant predictor for poor emotional QOL (OR = 5.03, p = 0.04). High serum ferritin was the statistically significant predictor for poor social QOL (OR = 1.1, CI 95%=, p = 0.04). Regarding poor psychological QOL (OR = 0.94, p = 0.01) and total QOL (OR = 0.94, p = 0.01) scores, older age of starting transfusion was the statistically significant protecting factor.ConclusionScheduled programs giving psychosocial help and a network connecting between the patients, school officials, thalassemia caregivers and the physician is required especially in developing countries where the health services are not integrated with social organizations. Special school services for thalassemia patients are required to deal with the repeated absence and anemia induced low mental performance of thalassemia children.

Health related quality of life among children with transfusion dependent β-thalassaemia major and haemoglobin E β-thalassaemia in Sri Lanka: a case control study

“…This suggests that the improvements in medical care may not have contributed substantially to upgrade the quality of life of these patients. However, the quality of life scores reported in these studies are significantly higher than the scores reported among patients in Egypt [29]. This is probably due to the difference in the clinical management where patients in south and southeast Asia receiving better levels of transfusion and chelation compared to patients in Africa.…”

“…Secondly, we compared the HRQoL scores of patients with β-thalassaemia with that of healthy controls therefore, a generic questionnaire was deemed more suitable. Also, PedsQL 4.0 questionnaire was easy to use and has been widely used among patients with thalassaemia previously [20,29].…”

Health-related quality of life among children with transfusion-dependent thalassemia: A cross-sectional study in Malaysia

“…The Psychosocial Health Summary Score was consistently found to be lower compared to the Physical Health Summary Score in previous studies conducted in Malaysia [7][8][9], Thailand [10][11][12] or the Middle East [16,31,32]. We found that the school functioning dimension had the lowest mean score in this study.…”

Health-Related Quality of Life Among Children With Transfusion-Dependent Thalassemia: A Cross-Sectional Study in Malaysia

“…The Psychosocial Health Summary Score was consistently found to be lower compared to the Physical Health Summary Score in previous studies conducted in Malaysia(7-9), Thailand (10)(11)(12) or the Middle East (16,31,32). We found that the school functioning dimension had the lowest mean score in this study.…”