Health-related quality of life in adult patients with esophageal atresia—a questionnaire study

Koivusalo, Antti; Pakarinen, Mikko P.; Turunen, Päivi; Saarikoski, Hanna; Lindahl, Harry; Rintala, Risto

doi:10.1016/j.jpedsurg.2004.10.014

Cited by 92 publications

(57 citation statements)

References 11 publications

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“…The incidence of gastrointestinal and respiratory symptoms is thought to decrease by time [9,11,12]. In our study, we were surprised to find out that gastrointestinal and respiratory symptoms did not improve as the patients became older.…”

Section: Discussionmentioning

confidence: 52%

“…The outcome of neonates with EA has dramatically improved since Haight and Towsley [2] reported the first successful primary repair in 1943. Even though advances in neonatal, pediatric surgical and cardiac care have improved the overall survival rate in infants with EA [3][4][5][6][7][8] gastrointestinal and respiratory symptoms are reported in long-term follow-up studies and may interfere with normal life [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Outcome in neonates with esophageal atresia treated over the last 20 years

Lilja

Wester

2008

Pediatr Surg Int

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We evaluated the outcome in infants with esophageal atresia (EA) treated in our department over the last two decades. The medical records of 147 infants treated from 1986 to 2005 were reviewed. Patient characteristics, associated anomalies, surgery and complications were recorded. We divided the material into two time-periods: 1986-1995 and 1996-2005; 125 patients or parents were interviewed regarding gastrointestinal function, respiratory symptoms and education. The incidence of major cardiac defects increased from 23 to 29% and the overall survival increased from 87 to 94%. Using Spitz' classification survival increased from 93.5 to 100% in group I and from 68.4 to 77.8% in group II. In group III, during the second time period, survival was 100% in three patients. The incidence of anastomotic leakage and recurrent fistula did not change over time. The rate of anastomotic strictures increased from 53 to 59% between the two time-periods. A primary anastomosis could be done in 85% of the patients during the second period versus 78% of the patients during the first period. Anti-reflux surgery was done in only 11 and 9%, respectively, during the two time-periods. In patients who were 16-20 years old, 40-50% had gastrointestinal and respiratory symptoms. Ninety percent of the patients attended normal school. The major difference between the periods 1986-1995 and 1996-2005 was an increased survival despite an increased incidence of major cardiac defects. Gastrointestinal and respiratory symptoms were frequent. Long-term follow-up and treatment of complications of esophageal atresia is important for this patient group.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Outcome in neonates with esophageal atresia treated over the last 20 years

Lilja

Wester

2008

Pediatr Surg Int

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“…Moreover, several of our patients are born prematurely with incomplete development that predisposes to lung disease of prematurity [7]. Finally many of our patients with CDH and tracheo-oesophageal fistula/ oesophageal atresia have chronic respiratory morbidity that affects growth and may affect decisions for further surgeries (such as fundoplication) [8,9] (Fig. 1).…”

Section: Why Lung Development Matters To Paediatric Surgeonsmentioning

confidence: 97%

Exploiting mechanical stimuli to rescue growth of the hypoplastic lung

Jesudason

2007

Pediatr Surg Int

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Impaired lung development afflicts a range of newborns cared for by paediatric surgeons. As a result the speciality has led in the development of surgical models that illustrate the biomechanical regulation of lung growth. Using transgenic mutants, biologists have similarly discovered much about the biochemical regulation of prenatal lung growth. Airway smooth muscle (ASM) and its prenatal contractility airway peristalsis (AP) represent a novel link between these areas: ASM progenitors produce an essential biochemical factor for lung morphogenesis, whilst calcium-driven biomechanical ASM activity appears to regulate the same. In this invited paper, I take the opportunity both to review our recent findings on lung growth and prenatal ASM, and also to discuss mechanisms by which ASM contractility can regulate growth. Finally, I will introduce some novel ideas for exploration: ASM contractility could help to schedule parturition (pulmonary parturition clock) and could even be a generic model for smooth muscle regulation of morphogenesis in similar organs.

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“…In einer Erhebung zur langfristigen Lebensqualität nach Korrektur der ÖA gaben 275 Erwachsene in 3 Studien eine Lebensqualität an, die derjenigen gesunder Kontrollpersonen entsprach [13,14,15]. Patienten mit korrigierter ÖA sind an Zentren anzubinden, die sich mit einem interdisziplinären Team auf diese Aufgabe spezialisiert haben.…”

Section: Prognose/nachsorgeunclassified