Health-related quality of life in patients with skull base tumours

Kelleher, Michael O.; Fernandes, Mariana; Sim, Davis; O'Sullivan, M G

doi:10.1080/02688690120114183

Cited by 68 publications

(62 citation statements)

References 11 publications

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“…No significant difference was found in terms of GBI scores between patients with and without facial dysfunction, nor between those with different House-Brackmann grades [26] . The study by Kelleher et al [17] supports the latter findings. According to that study, the degree of postoperative facial nerve dysfunction did not influence the SF-36 QoL scores of their VS patients.…”

Section: Studies In Vs Patients Managed Conservativelysupporting

confidence: 81%

“…In their prospective study, Kelleher et al [17] found that VS patients managed conservatively with serial MRI had a QoL similar to that of the normal population, when QoL was measured using the SF-36. In another study, the SF-36 scores of a group of VS patients managed with interval MRI scanning were compared to those of a group of patients having symptoms similar to those of VS patients while attending the general otolaryngology clinic in the authors' institution.…”

Section: Studies In Vs Patients Managed Conservativelymentioning

confidence: 99%

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Quality of Life in Sporadic Vestibular Schwannoma: A Review

Gouveris

Mann²

2010

ORL

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Quality of life (QoL) measures are increasingly used as outcome measures in the assessment of different treatment options in clinical practice and as endpoints in clinical trials. Methods and questionnaires currently used for QoL assessment in vestibular schwannoma (VS) patients, studies evaluating QoL before and after treatment, studies on patients managed conservatively and studies evaluating facial-nerve-function-related QoL in VS patients are reviewed. Current methodological controversial issues in QoL studies on VS patients include the lack of a planned prospective comparison between QoL values before and after treatment, a need for the inclusion of additional questions along with standard questionnaires and the need to report on both the statistical and the clinical significance of QoL data. QoL assessments merit being included in more trials along with standardized interpretation and complete reporting of results.

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Section: Studies In Vs Patients Managed Conservativelysupporting

confidence: 81%

Section: Studies In Vs Patients Managed Conservativelymentioning

confidence: 99%

Quality of Life in Sporadic Vestibular Schwannoma: A Review

Gouveris

Mann²

2010

ORL

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“…13,19 Skull Base Surgery and QOL Several studies have examined the QOL outcomes following a wide range of surgical treatments for a variety of tumors at various locations in the cranial base. 16,[20][21][22][23][24][25][26][27][28] Accordingly, the QOL outcomes from these studies are variable, reflecting the heterogeneity of the pathologies, surgical treatments, study designs, and QOL instruments utilized during the assessments. Although these confounding variables make it difficult to identify specific areas where changes may be implemented, there is little doubt that there is a clear need for surgical approaches to the skull base that reduce morbidity and improve the QOL.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life Following Endonasal Skull Base Surgery

Pant¹,

Snyderman²,

Bhatki³

et al. 2009

Skull Base

142

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The importance of quality of life (QOL) outcomes following treatments for head and neck tumors are now increasingly appreciated and measured to improve medical and surgical care for these patients. An understanding of the definitions in the setting of health care and the use of appropriate QOL instruments and measures are critical to obtain meaningful information that guides decision making in various aspects of patient health care. QOL outcomes following cranial base surgery is only recently being defined. In this article, we describe the current published data on QOL outcomes following cranial base surgery and provide preliminary prospective data on QOL outcomes and sinonasal morbidity in patients who underwent endonasal cranial base surgery for management of various skull base tumors at our institution. We used a disease-specific multidimensional instrument to measure QOL outcomes in these patients. Our results show that although sinonasal morbidity is increased, this is temporary, and the vast majority of patients have a very good QOL by 4 to 6 months after endonasal approach to the cranial base.

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“…While some authors suggest that facial paresis has a significant bearing on postoperative QOL, 4,17,22 others found no difference in QOL between patients with and without facial nerve dysfunction, or between those with different grades of facial nerve function. 15,16,25 Schwartz et al 28 have noted no significant difference in QOL between patients with good versus poor facial nerve function. They proposed that since patients with poor facial nerve function had larger tumors, they may have been more able to reconcile their facial weakness, without perceiving it as a major QOL problem.…”

Section: Facial Functionmentioning

confidence: 99%

Quality of life following surgery for large and giant vestibular schwannomas: a prospective study

Turel¹,

Thakar²,

Rajshekhar³

2015

JNS

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A discrepAncy between surgeon-assessed and patient-perceived outcomes of vestibular schwannoma (VS) surgery has been reported. 16,19,22 Hence, there is a need for greater emphasis on quality of life (QOL) outcomes (which are patient reported) following surgery for VS. Most of the QOL studies in patients undergoing surgery for VS are retrospective and include patients with small tumors. [1][2][3][4][5][6][7]14,18,21,23,27,28,31 Few studies have reported QOL following surgery for large VS, but even those have mostly been retrospective in nature. 22,25One of the major deficiencies in QOL studies on VS patients is the lack of a planned prospective comparison between QOL values before and after treatment in large cohorts of patients. 10,11 The few published prospective studies involved patients with small VSs (< 3 cm). 20,24,26 To our knowledge there is only one prospective report of QOL in patients with larger tumors (> 3 cm), and that study involved 37 patients. 8None of the reports of QOL in patients with VS have included the proportion of patients showing a minimum clinically important difference (MCID) in the different QOL domains. Surgeons need to know whether an observed change in score represents a clinically important improvement or deterioration rather than merely an inconsequential fluctuation. Differences in scores smaller than the MCID are considered unimportant, regardless of whether statistical significance is reached. To date, such information has not been provided in any published report on QOL in VS patients.We aimed to study the factors affecting QOL in pa- OBJect Prospective studies of quality of life (QOL) are infrequently performed in patients undergoing surgery for vestibular schwannoma (VS). The authors designed this to study to investigate health-related QOL (HR-QOL) in patients with large and giant VSs before and after surgery. methOdS Between January 2009 and December 2012, HR-QOL was measured prospectively before and after surgery, using the 36-Item Short Form Health Survey (SF-36), in 100 patients who underwent surgery for unilateral large or giant VS (tumor size ≥ 3 cm). The Glasgow Benefit Inventory (GBI) was also used to evaluate the effect of surgery. reSultS A total of 100 patients were included in the study (65 men and 35 women). Their mean age (± SD) was 44.2 ± 11.5 years. The preoperative QOL was decreased in all SF-36 domains. A 1-year follow-up evaluation was conducted for all patients (mean 13.5 ± 5.3 months after surgery). The results showed an improvement in HR-QOL compared with preoperative status in all cases, with 63%-85% of patients showing a minimum clinically important difference (MCID) in various domains. A second follow-up evaluation was performed in 51 cases (mean time after surgery, 29.0 ± 8.3 months) and showed sustained improvement in SF-36 scores. In some domains there was further improvement beyond the first follow-up. On the GBI, 87% of patients reported improvement, 1% felt no change, and 12% of patients reported deterioration. cONcluSiONS Patients harboring l...

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Health-related quality of life in patients with skull base tumours

Cited by 68 publications

References 11 publications

Quality of Life in Sporadic Vestibular Schwannoma: A Review

Quality of Life in Sporadic Vestibular Schwannoma: A Review

Quality of Life Following Endonasal Skull Base Surgery

Quality of life following surgery for large and giant vestibular schwannomas: a prospective study

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