Health‐related quality of life (HRQOL) among pediatric leukemia patients in Malaysia

Alias, Hamidah; Wong, CS; Tamil, Azmi Mohd; Zarina, Latiff A.; Zulkifli, Zakaria S.; Jamal, Rahman

doi:10.1002/pbc.23125

Cited by 15 publications

(13 citation statements)

References 14 publications

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“…The mean values for physical parameters are comparable to the results published in the similar previous studies 5, 11,12,14 . In general, we detected a negative impact of malignancies on HRQOL parameters tested with PedsQL scales.…”

Section: Discussionsupporting

confidence: 90%

Health-related quality of life assessment in Serbian schoolchildren hospitalized for malignant disease

Nedović¹,

Marinković²,

Rapaić³

et al. 2013

VOJNOSANIT PREGL

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The Serbian version of PedsQL 4.0 Generic Core Scales could be successfully used to evaluate physical, emotional, social and school functioning of hospitalized children and adolescent. Schoolchildren hospitalized for prolonged tumor treatment have poorer HRQOL scores compared to general healthy population, however the level of remaining physical, emotional and social parameters should provide solid foundation for their potential rehabilitation, education and inclusion.

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Section: Discussionsupporting

confidence: 90%

Health-related quality of life assessment in Serbian schoolchildren hospitalized for malignant disease

Nedović¹,

Marinković²,

Rapaić³

et al. 2013

VOJNOSANIT PREGL

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“…In addition, our results may be limited by the use of proxy reporting of the severity of subjective symptoms. We were not able to correlate our findings with real‐time clinical assessments of symptom severity, and in comparison with self‐reporting by children, parents may underestimate or overestimate the severity of children's symptoms . Indeed, a parent's ability to cope with his or her child's treatment may influence the report of the child's symptom severity or the child's actual symptom severity .…”

Section: Discussionmentioning

confidence: 66%

Anxiety, pain, and nausea during the treatment of standard‐risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group

Dupuis

Mitchell

et al. 2016

Cancer

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BACKGROUND This prospective study describes the procedure-related anxiety, treatment-related anxiety, pain, and nausea experienced by children with standard-risk acute lymphoblastic leukemia (ALL) during the first year of treatment. METHODS This study was undertaken at 31 Children’s Oncology Group (COG) sites. Eligible children who were 2 to 9.99 years old were enrolled in a COG trial for patients with newly diagnosed standard-risk ALL from 2005 to 2009. Parents completed a demographic survey at the baseline and the Pediatric Quality of Life Inventory 3.0 Cancer Module (proxy version) and the General Functioning Scale of the Family Assessment Device 1, 6, and 12 months after the diagnosis. The association between patient-related (age, sex, ethnicity, and treatment), parent-related (marital status and education), and family-related factors (functioning, income, and size) and symptom scores was evaluated. RESULTS The mean scores for procedure-related anxiety, treatment-related anxiety, and pain improved during the first year of treatment (P < .0389). The mean nausea score was poorer 6 months after the diagnosis in comparison with the other assessments (P = .0085). A younger age at diagnosis was associated with significantly worse procedure-related anxiety (P = .004). An older age (P = .0002) and assignment to the intensified consolidation study arm (P = .02) were associated with significantly worse nausea. CONCLUSIONS Children with ALL experienced decreasing treatment-related anxiety, procedure-related anxiety, and pain during the first year of treatment. In comparison with scores at 1 and 12 months, nausea was worse 6 months after the diagnosis. Minimization of procedure-related anxiety in younger children and improved nausea control in older children and those receiving more intensified treatment should be prioritized.

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“…van Litsenburg et al [8] reported clinically important impaired HRQL scores of ALL survivors compared to the norms. ALL treatment impairs daily activities, family life, and school success, leading to low quality of life [17]. It is known that hospitalization for chemotherapy leads to problems such as social alienation and loneliness.…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors

Baytan

Aşut²,

Kantarcıoğlu³

et al. 2016

Tjh

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Objective:With increasing survival rates in childhood acute lymphocytic leukemia (ALL), the long-term side effects of treatment have become important. Our aim was to investigate health-related quality of life, depression, anxiety, and self-image among ALL survivors.Materials and Methods:Fifty patients diagnosed with ALL and their siblings were enrolled. The Kovacs Children’s Depression Inventory, State-Trait Anxiety Inventory, Offer Self-Image Questionnaire, and Pediatric Quality of Life InventoryTM were used for collecting data. ANOVA tests were used to determine if there were any significant differences between groups.Results:ALL survivors had higher depression, more anxiety symptoms, lower quality of life, and more negative self-image when compared to their siblings.Conclusion:Continuous diagnostic and interventional mental health services might be necessary for possible emotional side effects of treatment during and after the treatment. Rehabilitation and follow-up programs should be implemented for children during and after treatment for ALL.

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Health‐related quality of life (HRQOL) among pediatric leukemia patients in Malaysia

Abstract: Pediatric acute leukemia patients on maintenance chemotherapy experienced significantly poorer HRQOL compared to those off-treatment.

Cited by 15 publications

References 14 publications

Health-related quality of life assessment in Serbian schoolchildren hospitalized for malignant disease

Health-related quality of life assessment in Serbian schoolchildren hospitalized for malignant disease

Anxiety, pain, and nausea during the treatment of standard‐risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group

Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors

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