Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission

Impact of age and cranial irradiation on radiographic skeletal pathology in children with acute lymphoblastic leukemia

“…Bone pain is the most prevalent morbidity in children with ALL while they receive treatment in our institution [16]. It is related to loss of bone mineral mass and perturbation of mineral homeostasis [1].…”

Multiattribute approach to the assessment of health-related quality of life: Health utilities index

“…The HUI was shown to be responsive in a small study of 18 consecutive patients who were on maintenance therapy for ALL [40]. Children were assessed at each clinic visit by a nurse who was blinded to the stage of the treatment cycle and to methodological hypotheses, using HUI2 and HUI3.…”

Construct validation of the Health Utilities Index and the Child Health Questionnaire in children undergoing cancer chemotherapy

“…Both the HUI and CHQ are recommended for children of age greater than 5 years (Landgraf et al, 1996;Furlong et al, 2001). However, two of the studies examining the HUI in children undergoing anticancer therapy included children under the age of 5 years (Barr et al, 1997;Trudel et al, 1998); and specifically, the report by Barr et al (1997) included children as young as 11 months with a median age of 3 years 11 months. Both studies demonstrated that the HUI was reliable and valid in this population and age range.…”

“…(Feeny et al, 1992;Barr et al, 1997;Trudel et al, 1998). These showed that the HUI was able to discriminate between children on and off treatment for cancer and was responsive to different phases of treatment in children receiving maintenance therapy for acute lymphoblastic leukaemia (ALL).…”