Health-Related Quality of Life, Depression, and Metabolic Parameters in Overweight Insulin-Resistant Adolescents

Platt, Adrienne M.; Egan, Anna; Berquist, Mary Jane; Dreyer, M; Babar, Ghufran; Ugrasbul, Figen

doi:10.1016/j.pedhc.2011.06.015

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…From a clinical perspective, major depression and obesity have been linked in youths in treatment settings (Mansur et al, 2015; Marks et al, 2009; Morgan et al, 2002; Pauli-Pott et al, 2013; Platt et al, 2013; Pott et al, 2010). Given this, clinical interventions for youths who are depressed and obese perhaps should consider including strategies which focus on weight control as well as improving body image and symptoms of depression.…”

Section: Discussionmentioning

confidence: 99%

Does major depression affect risk for adolescent obesity?

Roberts

Duong

2015

Journal of Affective Disorders

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Objective The purpose of this paper is to reexamine the association between major depression and obesity in adolescents, testing the hypothesis that body image mediates this association. This is the first paper to examine this question using DSM-IV diagnosis of depression and data from a two-wave cohort of adolescents. Methods Participants were 4,175 youths 11–17 years of age sampled from the community who were followed up a year later (n = 3,134). Major depression was assessed using DSM-IV diagnostic criteria. Body image was measured with perceived weight. Obesity was defined as BMI > 95th percentile using measured height and weight. Results When we examined a model which included obesity, perceived weight, major depression and covariates, there was no association between major depression at baseline and obesity at follow-up. We found no independent association between major depression and body weight. Limitations The study was limited in that it is not a national sample, BMI was the only measure of adiposity, perceived weight was the only measure of body image, and there were no data on lifetime trajectories of depression, obesity, or body image. Conclusions If there is an etiologic link between major depression and body weight among adolescents, it most likely operates through processes involving components of body image, since controlling for body image eliminated the association between depression and obesity. Clinically, addressing body image in depressed patients who are obese may improve outcomes.

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Section: Discussionmentioning

confidence: 99%

Does major depression affect risk for adolescent obesity?

Roberts

Duong

2015

Journal of Affective Disorders

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“…There are some reports in the literature that indicate little or no association between metabolic syndrome/insulin resistance and depression 40,41. A recent systematic review and meta-analysis found a slight but significant cross-sectional relation between depression and insulin resistance 42.…”

Section: Discussionmentioning

confidence: 99%

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Güzel¹,

Bakkal²,

Güzel³

et al. 2014

NDT

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ObjectiveDepression is a common condition in obese women that can result in severe impairment of their physical and social functioning. A deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. The aim of this study is to investigate whether BDNF levels differ between obese female patients and healthy controls and whether BDNF levels alter with affective states in depressive obese women.MethodsThe study group included 40 obese, 40 preobese, and 40 normal weight women. BDNF levels were measured with an enzyme-linked immunosorbent assay in patient and control groups. For identifying the depression and anxiety status, Beck Depression/Anxiety Inventories were used; and for the evaluation of cognitive functions, the mini-mental state examination was used.ResultsBDNF levels were significantly lower in obese patients compared to the control group (P<0.01). BDNF levels were significantly lower in obese patients with depression compared to the obese patients without depression (P<0.05). The Beck Depression Inventory showed a negative correlation with BDNF (r=−0.044; P<0.01) and a positive correlation with the Beck Anxiety Inventory (r=0.643; P<0.001), vitamin B12 levels (r=0.023; P<0.001), and insulin levels (r=0.257; P<0.05) in obese patients. When receiver operating characteristic curve analysis was used to analyze the suitability of BDNF to identify depression in obese women, the area under the curve for BDNF, 0.756, was found to be significant (P=0.025). BDNF levels lower than 70.2 pg/mL were associated with a higher prevalence of depressive symptoms.ConclusionThe results of our study suggest that the decrease in BDNF levels can be used as a marker for depression diagnosis in obese patients.

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“…Depression is associated with pre-diabetes insulin resistance (Anderson et al, 2001; Kan et al, 2013) and obesity (Hamer et al, 2012). However, there exists a weak association of insulin resistance and depression (Adriaanse et al, 2006; Platt et al, 2013; Shen and Bergquist-Beringer, 2013). High fat diet intake impairs the hypothalamic insulin receptor signaling (De Souza et al, 2005; Kim and Feldman, 2012) and reduced hypothalamic insulin signaling promotes weight gain and negative emotional states (Gustafson et al, 1999; Koponen et al, 2008; Akbaraly et al, 2009; Almeida et al, 2009; Benoit et al, 2009; Kleinridders et al, 2009; Pulkki-Raback et al, 2009; Platt et al, 2013).…”

Section: Peripheral System In Regulation Of Mood Food and Obesitymentioning

confidence: 99%

Mood, food, and obesity

2014

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Food is a potent natural reward and food intake is a complex process. Reward and gratification associated with food consumption leads to dopamine (DA) production, which in turn activates reward and pleasure centers in the brain. An individual will repeatedly eat a particular food to experience this positive feeling of gratification. This type of repetitive behavior of food intake leads to the activation of brain reward pathways that eventually overrides other signals of satiety and hunger. Thus, a gratification habit through a favorable food leads to overeating and morbid obesity. Overeating and obesity stems from many biological factors engaging both central and peripheral systems in a bi-directional manner involving mood and emotions. Emotional eating and altered mood can also lead to altered food choice and intake leading to overeating and obesity. Research findings from human and animal studies support a two-way link between three concepts, mood, food, and obesity. The focus of this article is to provide an overview of complex nature of food intake where various biological factors link mood, food intake, and brain signaling that engages both peripheral and central nervous system signaling pathways in a bi-directional manner in obesity.

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Health-Related Quality of Life, Depression, and Metabolic Parameters in Overweight Insulin-Resistant Adolescents

Cited by 9 publications

References 20 publications

Does major depression affect risk for adolescent obesity?

Does major depression affect risk for adolescent obesity?

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Mood, food, and obesity

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Health-Related Quality of Life, Depression, and Metabolic Parameters in Overweight Insulin-Resistant Adolescents

Cited by 9 publications

References 20 publications

Does major depression affect risk for adolescent obesity?

Does major depression affect risk for adolescent obesity?

Can low brain-derived neurotrophic factor levels&nbsp;be a marker of the presence of depression in&nbsp;obese women?

Mood, food, and obesity

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Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?