Health-related quality of life compared between kidney transplantation and nocturnal hemodialysis

Jansz, Thijs T.; Bonenkamp, Anna A; Boereboom, F. T. J.; Reekum, Franka E. van; Verhaar, Marianne C.; Jaarsveld, Brigit C. van

doi:10.1371/journal.pone.0204405

Cited by 37 publications

(27 citation statements)

References 27 publications

(30 reference statements)

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“…Compared with HD and PD groups, Tx patients signi cantly enjoyed a better quality of life and suffered less from psychological problems. The results veri ed that treatment modality was one of the most important factors affecting HRQOL psychological states of ESRD patients, and Tx was superior to the other two treatments, which was in accordance with the previous studies [2,7,[12][13][14][15][16][17][18]. It is of necessity to increase the access to Tx, whereas there still exists a remarkably prominent variation in the access to and the use of Tx across the world.…”

Section: Discussionsupporting

confidence: 90%

“…The comparison studies about HD and PD demonstrated that the HRQOL tended to be better in PD patients, especially in terms of physical component, illness intrusion, social support, social function and mental health and satisfaction with care [4,[9][10][11]. The compared HRQOL scores of Tx patients were prominently higher than those of patients under dialysis treatment in most dimensions such as role physical, bodily pain, social function, role emotional and mental health [7,[12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Quality of Life and Depression in Patients With End-stage Renal Disease: a Comparison of Renal Replacement Therapy Modalities

Yang¹,

Yang²,

Cheng³

et al. 2021

Preprint

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Purpose. Patients with end-stage renal disease (ESRD) face various physical and mental limitations resulting from different renal replacement therapy (RRT) modalities. Renal transplantation (Tx) is considered as the treatment that impacts most on health-related quality of life (HRQOL). This study aimed to analyze and compare the HRQOL and depression levels of patients undergoing hemodialysis (HD), peritoneal dialysis (PD) and Tx.Methods. A single-center cross-sectional sample of 112 HD patients, 68 PD patients and 97 Tx patients participated in our questionnaire survey. The HRQOL and depression levels were assessed through the 36-Item Short-Form Health Survey (SF-36) and Mental Health Inventory (MHI-5), respectively. The multiple linear regression model was performed to examine the factors associated with each of the HRQOL scale scores. Results. The SF-36 HRQOL of Tx patients differed significantly from that in HD and PD groups in all eight dimensions and two components (all P<0.001). More than 45% of patients in each group were facing depressive symptoms. HD patients (63.4%) and PD (67.6%) patients were more depressive compared with Tx patients (45.4%, P =0.006). Depression in ESRD patients contributed to a worse quality of life (P<0.001). Patients ranging in age from 31 to 50, having full-time jobs, receiving Tx and without depression were associated with better HRQOL in the domain of Physical Component Scores (PCS). Patients with unemployment, dismissal or being looking for a job, receiving Tx and without depression were associated with better HRQOL in the domain of Mental Component Scores (MCS).Conclusions. Tx patients had better HRQOL and less depressive symptoms than HD and PD patients. Depression was related to an impaired HRQOL, which was common in ESRD patients. The severity of depression in ESRD patients and the effectiveness of Tx on HRQOL improvement need to be underscored.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Quality of Life and Depression in Patients With End-stage Renal Disease: a Comparison of Renal Replacement Therapy Modalities

Yang¹,

Yang²,

Cheng³

et al. 2021

Preprint

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“…Table). For RRT treatments, KTx recipients reported higher mean generic and specific scores relative to those on dialysis [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83] (S2-S4 Tables). Nagaraja et al [44] converted the SF-36 data into SF-6D utility scores and showed a similar relationship; kidney transplantation was associated with better mean SF-6D utility scores relative to HD (0.65± SD: 0.13 vs 0.52± SD: 0.11, respectively).…”

Section: The Kdqol-sf™ Toolmentioning

confidence: 99%

The impact of chronic kidney disease on developed countries from a health economics perspective: A systematic scoping review

et al. 2020

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Chronic kidney disease (CKD) affects over 10% of the global population and poses significant challenges for societies and health care systems worldwide. To illustrate these challenges and inform cost-effectiveness analyses, we undertook a comprehensive systematic scoping review that explored costs, health-related quality of life (HRQoL) and life expectancy (LE) amongst individuals with CKD. Costs were examined from a health system and societal perspective, and HRQoL was assessed from a societal and patient perspective. Papers published in English from 2015 onward found through a systematic search strategy formed the basis of the review. All costs were adjusted for inflation and expressed in US$ after correcting for purchasing power parity. From the health system perspective, progression from CKD stages 1-2 to CKD stages 3a-3b was associated with a 1.1-1.7 fold increase in per patient mean annual health care cost. The progression from CKD stage 3 to CKD stages 4-5 was associated with a 1.3-4.2 fold increase in costs, with the highest costs associated with end-stage renal disease at $20,110 to $100,593 per patient. Mean EuroQol-5D index scores ranged from 0.80 to 0.86 for CKD stages 1-3, and decreased to 0.73-0.79 for CKD stages 4-5. For treatment with renal replacement therapy, transplant recipients incurred lower costs and demonstrated higher HRQoL scores with longer LE compared to dialysis patients. The study has provided a comprehensive updated overview of the burden associated with different CKD stages and renal replacement therapy modalities across developed countries. These data will be useful for the assessment of new renal services/ therapies in terms of cost-effectiveness.

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“…Kidney transplantation (KTx) is the most desired renal replacement therapy for patients with end-stage renal disease (ESRD), with salutary effects on quality of life (QOL) [1] and overall survival [2] compared to dialysis. However, cardiovascular disease (CVD) remains one of the leading causes of death in kidney transplant recipients (KTRs), accounting for 17% [3] of total deaths, and KTRs have an overall mortality rate at least 5–10-fold greater than the general population [4].…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise training on cardiovascular risk factors in kidney transplant recipients: a systematic review and meta-analysis

Chen

Gao

2019

Renal Failure

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Background: Whether exercise can improve cardiovascular health in kidney transplant recipients (KTRs) is unclear. Therefore, we performed a systematic review of the effects of exercise on cardiovascular risk factors in this population setting. Methods: Randomized control trials (RCTs) evaluating the impact of exercise on major clinical outcomes in KTRs were identified by searches in Cochrane CENTRAL, PubMed, EMBASE, OVID and CBM updated to December 2018. The main outcomes of interest were blood pressure, lipid profile, blood glucose level, arterial stiffness, kidney function, body weight, body mass index, exercise tolerance (VO 2 peak) and quality of life (QOL). Results: After screening 445 studies in the database, we included 12 RCTs in the review and 11 RCTs for further qualitative analysis. The results indicate a significant improvement in small arterial stiffness [mean difference (MD): −1.14, 95% confidence interval (CI): −2.19–0.08, p = .03], VO 2 peak (MD: 2.25, 95% CI: 0.54–3.69, p = .01), and QOL (MD: 12.87, 95% CI: 6.80–18.94, p < .01) after exercise intervention in KTRs. However, there is no evidence for an improvement in blood pressure, lipid profile, blood glucose level, kidney function, body weight or body mass index. Conclusion: Exercise intervention in KTRs improves arterial stiffness but does not consistently contribute to the modification of other CVD risk factors like hypertension, dyslipidemia, hyperglycemia, decreased kidney function and obesity. Exercise also improves exercise tolerance and QOL in KTRs.

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Health-related quality of life compared between kidney transplantation and nocturnal hemodialysis

Cited by 37 publications

References 27 publications

Quality of Life and Depression in Patients With End-stage Renal Disease: a Comparison of Renal Replacement Therapy Modalities

Quality of Life and Depression in Patients With End-stage Renal Disease: a Comparison of Renal Replacement Therapy Modalities

The impact of chronic kidney disease on developed countries from a health economics perspective: A systematic scoping review

Effects of exercise training on cardiovascular risk factors in kidney transplant recipients: a systematic review and meta-analysis

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