Health-related quality of life associated with warfarin and direct oral anticoagulants in venous thromboembolism

Fang, Margaret C.; Go, Alan S.; Prasad, Priya; Zhou, Hui X; Parks, Anna L.; Fan, Dongjie; Portugal, Cecilia; Sung, Sue Hee; Reynolds, Kristi

doi:10.1016/j.thromres.2022.06.008

Cited by 3 publications

(1 citation statement)

References 17 publications

(23 reference statements)

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“…Data about whether the type of drug therapy (DOACs or Vit K antagonists) may influence QoL are conflicting. Some studies report that QoL is better in patients receiving DOACs over Vit K antagonists [ 38 ], while others challenge this finding [ 39 ]. The discrepancies among studies may be attributed to the differences in sample size among studies.…”

Section: Mental Health Aspects Of Pulmonary Embolismmentioning

confidence: 99%

Mental Health and Quality of Life in Pulmonary Embolism: A Literature Review

Gkena

Kirgou

Gourgoulianis

et al. 2023

Advances in Respiratory Medicine

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Pulmonary embolismis an acute disease with chronic complications and, although it is not considered a chronic disease, it requires close follow-up. The scope of the present literature review is to decode the existing data concerning quality of life and the mental health impact of PE during the acute and long-term phases of the disease. The majority of studies reported impaired quality of life in patients with PE when compared to population norms, both in the acute phase and >3 months after PE. Quality of life improves over time, irrespectively of the measurement used. Fear of recurrences, elderly, stroke, obesity, cancer and cardiovascular comorbidities are independently associated with worse QoL at follow-up. Although disease specific instruments exist (e.g., the Pulmonary Embolism Quality of Life questionnaire), further research is required in order to develop questionnaires that may fulfil international guideline requirements. The fear of recurrences and the development of chronic symptoms, such as dyspnea or functional limitations, may further impair the mental health burden of PE patients. Mental health may be implicated by post-traumatic stress disorder, anxiety and depressive symptoms present following the acute event. Anxiety may persist for 2 years following diagnosis and may be exaggerated by persistent dyspnea and functional limitations. Younger patients are at higher risk of anxiety and trauma symptoms while elderly patients and patients with previous cardiopulmonary disease, cancer, obesity or persistent symptoms exhibit more frequently impaired QoL. The optimal strategy for the assessment of mental health in this patient pool is not well defined in the literature. Despite mental burden being common following a PE event, current guidelines have not incorporated the assessment or management of mental health issues. Further studies are warranted to longitudinally assess the psychological burden and elucidate the optimal follow-up approach.

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Section: Mental Health Aspects Of Pulmonary Embolismmentioning

confidence: 99%

Mental Health and Quality of Life in Pulmonary Embolism: A Literature Review

Gkena

Kirgou

Gourgoulianis

et al. 2023

Advances in Respiratory Medicine

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Comparison of important factors to patients recovering from pulmonary embolism and items covered in patient-reported outcome measures: A mixed-methods systematic review

Ingemann-Molden,

Caspersen,

Rolving

et al. 2024

Thrombosis Research

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Patient‐Reported Outcomes in Venous Thromboembolism: A Systematic Review of the Literature, Current Challenges, and Ways Forward

Snyder,

Zilinyi,

Cohen

et al. 2023

JAHA

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Background Venous thromboembolism (VTE) affects >1.2 million Americans annually. Although the clinical outcomes and economic burdens of VTE have been well described, the impact of VTE on patients' health status has yet to be summarized. This systematic review summarizes how patient‐reported outcome measures (PROMs) have been used in VTE to date. Methods and Results PubMed/MEDLINE was queried for literature published through March 2023 using PROMs in a population of patients with VTE. Studies were excluded if the reference was an editorial, review, or case report, or if the study included patients with conditions other than VTE. Qualitative analyses were performed. After screening and exclusion, 136 references were identified; 5 described PROM development, 20 focused on PROM validation, and 111 used PROMs in outcomes research. The most used generic PROMs were the 36‐item Short‐Form Health Survey and EuroQol 5‐dimensional questionnaire, and the most common disease‐specific PROMs were the Venous Insufficiency Epidemiological and Economic Study–Quality of Life/Symptoms and the Pulmonary Embolism Quality of Life Questionnaire. PROMs were used to quantify the changes in health status after diagnosis, characterize the trajectory of subsequent improvement, and identify drivers of continued impairments in health status like postthrombotic syndrome and postpulmonary embolism syndrome. PROMs were also used to investigate the impact of novel treatment modalities on quality of life. Conclusions This review demonstrates the many benefits of PROM use, including quantifying changes in health status with treatment, capturing patients' experiences with the treatment itself, and identifying complications of VTE. Incorporating PROMs into VTE care will be an essential component of evaluating the effectiveness of novel therapies and should lead to improved shared decision‐making for patients with VTE.

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Health-related quality of life associated with warfarin and direct oral anticoagulants in venous thromboembolism

Cited by 3 publications

References 17 publications

Mental Health and Quality of Life in Pulmonary Embolism: A Literature Review

Mental Health and Quality of Life in Pulmonary Embolism: A Literature Review

Comparison of important factors to patients recovering from pulmonary embolism and items covered in patient-reported outcome measures: A mixed-methods systematic review

Patient‐Reported Outcomes in Venous Thromboembolism: A Systematic Review of the Literature, Current Challenges, and Ways Forward

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