Health-related quality of life and its predictors among patients with rheumatoid arthritis

Wan, Su Wei; He, Hong; Mak, Anselm; Lahiri, Manjari; Luo, Nan; Cheung, Peter; Wang, Wenru

doi:10.1016/j.apnr.2015.07.004

Cited by 52 publications

(29 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…RA patients often have a high prevalence of emotional stress, depression and anxiety [2]. Thus, considerable physical and psychological challenges can seriously damage these patients’ overall health-related quality of life (HRQOL) [3, 4]. In general, HRQOL refers to the ways in which a given health condition affects a patient’s physical ability and capacity to function in various social and emotional roles, including physical functioning and mental well-being [5].…”

Section: Introductionmentioning

confidence: 99%

Disease activity, resilience and health-related quality of life in Chinese patients with rheumatoid arthritis: a multi-center, cross-sectional study

Liu

et al. 2017

Health Qual Life Outcomes

View full text Add to dashboard Cite

BackgroundPositive psychological constructs that can moderate or mediate the negative impact of disease activity on health-related quality of life (HRQOL) in patients with rheumatoid arthritis (RA) have not been explored widely. This study aimed to assess the associations of disease activity, resilience with HRQOL and the moderating and mediating roles of resilience among Chinese RA patients.MethodsA multi-center, cross-sectional study was conducted in RA inpatients in northeast of China. A total 298 subjects completed the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) and Ego-Resiliency Scale (ERS) to measure HRQOL and resilience. For the SF-36, physical function, physical role limitation, bodily pain and general health perception are gathered into physical component summary (PCS), while vitality, social functioning, emotional role limitation and mental health are gathered into mental component summary (MCS). Disease activity was evaluated by the Disease Activity Score 28-C-reactive protein (DAS28-CRP). Hierarchical regression analysis was applied to examine the associations of disease activity, resilience and the disease activity*resilience interaction with PCS and MCS, respectively. Asymptotic and resampling strategies were utilized to examine the mediating role of resilience.ResultsThe mean scores of PCS and MCS were 40.67 and 59.14, respectively. Disease activity was negatively associated with both PCS and MCS, and resilience was only positively associated with MCS. The disease activity*resilience interaction term were significantly associated with MCS (β = 0.144, P = 0.003). The associations between disease activity and MCS were gradually reduced in low (1 SD below the mean, β = −0.369, P < 0.001), mean (β = −0.218, P < 0.001) and high (1 SD above the mean, β = −0.068, P = 0.369) groups of resilience. Resilience acted as a partial mediator in the disease activity-MCS association (effect size was −0.085, BCa 95% CI: −0.159, −0.028).ConclusionsDisease activity was negatively associated with both physical and mental HRQOL, and resilience was only positively associated with mental HRQOL. Resilience could attenuate and mediate the association between disease activity and mental HRQOL. In addition to controlling disease activity, targeted intervention strategies designed for resilience should be strengthened to improve the HRQOL of this population.

show abstract

Section: Introductionmentioning

confidence: 99%

Disease activity, resilience and health-related quality of life in Chinese patients with rheumatoid arthritis: a multi-center, cross-sectional study

Liu

et al. 2017

Health Qual Life Outcomes

View full text Add to dashboard Cite

show abstract

“…Rheumatoid arthritis is undoubtedly a disease which leaves permanent consequences of a psychological nature, especially in the emotional area, and affects quality of life. 17,20,29 There are many premises suggesting that personal predispositions of a patient, their competence and approach to the disease may have a considerable influence on the further course of the disease and its prognoses. According to Abu Al-Fadl et al and Maiden et al, during the treatment of patients with RA, more attention should be paid to the identification of symptoms of depression because the emotional condition affects the quality of life of patients and treatment outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…21,23,24 It was also shown that the quality of life of patients with RA depends on many factors of physical, mental and social functioning sphere. 17,[19][20][21][23][24][25][26][27][28][29][30][31] Studies conducted by many authors have shown that poorer functioning of the respondents in the physical sphere is conditioned by the duration of the disease. 18,24,26,28,30 Studies by Baloglu et al and Wisłowska et al did not confirm this dependence.…”

Section: Discussionmentioning

confidence: 99%

Knowledge and selected variables as determinants of the quality of life and general health of patients with rheumatoid arthritis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Patients with RA often experience diminished health-related quality of life (HRQOL) with respect to both physical functioning and emotional state due to the pain, stiffness, fatigue and disability that can result from this inflammation. [1][2][3][4] The goal of treatment in patients with RA is to reduce disease activity and improve patients' HRQOL. Patient-reported outcomes (PROs) are important measures when determining response to therapy in patients with RA, and patients report that, from their perspective, these measures of HRQOL are more important than traditional measures of clinical disease activity.…”

Section: Rmd Openmentioning

confidence: 99%

Impact of tocilizumab monotherapy on patient-reported outcomes in patients with rheumatoid arthritis from two randomised controlled trials

Strand

Michalska²,

Birchwood³

et al. 2017

RMD Open

View full text Add to dashboard Cite

ObjectiveTwo randomised controlled trials, AMBITION (NCT00109408) and ADACTA (NCT01119859), showed tocilizumab (TCZ) monotherapy superior to methotrexate (MTX) and adalimumab (ADA) monotherapy, respectively, for improving rheumatoid arthritis (RA) disease activity. This study compared the benefit of TCZ versus MTX or ADA monotherapy for improving patient-reported outcomes (PROs) in patients with RA.MethodsPROs included patient global assessment (PtGA), pain, Health Assessment Questionnaire Disability Index (HAQ-DI), Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue and Short Form-36 (SF-36) physical component summary (PCS) and mental component summary (MCS) and eight domain scores. Outcomes included proportions of patients reporting changes from baseline in PRO scores ≥minimum clinically important differences (MCID) and ≥age-matched and gender-matched normative values at 24 weeks.ResultsIn AMBITION, TCZ-treated patients reported significantly greater mean improvements in HAQ (−0.7 vs −0.5), FACIT-Fatigue (8.7 vs 5.7), SF-36 PCS (9.8 vs 7.8) and five SF-36 domains at week 24 than with MTX; 45.0%–84.0% of TCZ-treated patients reported improvements ≥MCID, and 24.3%–52.1% reported scores ≥normative values across all PROs versus 39.4%–81.8% and 14.5%–45.0%, respectively, with MTX. In ADACTA, TCZ-treated patients reported significantly greater improvements in PtGA (−42.3 vs −31.8), pain (−40.1 vs −28.7), SF-36 MCS (7.9 vs 5.0) and three SF-36 domains than with ADA; 57.7%–83.3% of TCZ-treated patients reported improvements ≥MCID, and 22.1%–49.3% reported scores ≥normative values across all PROs versus 13.6%–37.8%, respectively, with ADA.ConclusionsTCZ monotherapy resulted in more patients reporting clinically meaningful PRO improvements and PRO scores ≥normative values compared with MTX or ADA monotherapy.Trial registration numbers NCT00109408 and NCT01119859; Post-results.

show abstract

Health-related quality of life and its predictors among patients with rheumatoid arthritis

Cited by 52 publications

References 71 publications

Disease activity, resilience and health-related quality of life in Chinese patients with rheumatoid arthritis: a multi-center, cross-sectional study

Disease activity, resilience and health-related quality of life in Chinese patients with rheumatoid arthritis: a multi-center, cross-sectional study

Knowledge and selected variables as determinants of the quality of life and general health of patients with rheumatoid arthritis

Impact of tocilizumab monotherapy on patient-reported outcomes in patients with rheumatoid arthritis from two randomised controlled trials

Contact Info

Product

Resources

About