Health-related Quality of Life and Mental Health of Adults With Atopic Dermatitis

Kwak, Yeunhee; Kim, Yoonjung

doi:10.1016/j.apnu.2017.06.001

Cited by 31 publications

(36 citation statements)

References 33 publications

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“…Among a total of 4 770 767 participants, 310 681 were patients with AD (52.7% female) and 4 460 086 served as controls (50.9% female) ( Table 1). Seven articles 18,20,23,24,[26][27][28] studied only adults, 2 articles 22,25 studied only children (<18 years old), 3 articles 16,17,21 studied both adults and children, and 3 articles 14,15,19 did not report the age of the participants. The study locations included North America (n = 1), Europe (n = 6), Africa (n = 1), and Asia (n = 7) ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…40,41 In studies 16,27 comparing patients with mild AD vs patients with moderate to severe AD, patients with moderate to severe AD were found to have a higher prevalence of suicidal ideation but not completed suicides. Greater disease severity of AD is associated with increased sleep loss, more severe pruritus, and higher depression and anxiety rates, which can all contribute to more A and B, Shown are 11 studies 14,15,18,[20][21][22][24][25][26][27][28] suicidal ideation. 42 Despite these findings, there is a shortage of studies investigating subpopulations, and more studies are needed to better understand these associations.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Atopic Dermatitis and Suicidality

Sandhu

Bui

et al. 2019

JAMA Dermatol

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IMPORTANCE Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with numerous psychiatric comorbidities. However, the association between AD and suicidality has not been well established. OBJECTIVE To synthesize the available literature to evaluate the association between AD and suicidality. DATA SOURCE The protocol was prospectively registered in the PROSPERO database (CRD42018105291). STUDY SELECTION Per PRISMA guidelines, PubMed, Embase, PsycINFO, and Cochrane databases were systematically searched for relevant articles published from 1946 to May 25, 2018. The search criteria for PubMed were as follows: (dermatitis, atopic [MeSH] OR eczema [MeSH]) AND (suicidal ideation [MeSH] OR suicide, attempted [MeSH] OR suicide [MeSH] OR suicidality OR suicidal behavior). The search criteria for Embase, PsycINFO, and Cochrane were as follows: (atopic dermatitis OR eczema) AND (suicidal ideation OR suicide attempt OR suicide OR suicidality OR suicidal behavior). DATA EXTRACTION AND SYNTHESIS This systematic review and meta-analysis performed in an academic medical setting included observational studies that evaluated suicidal ideation, suicide attempts, and completed suicide among patients with AD. MAIN OUTCOME AND MEASURE The quality of included studies was assessed using the Newcastle-Ottawa Scale for observational studies. RESULTS The analysis identified 15 studies with a total of 4 770 767 participants, of whom 310 681 were patients with AD (52.7% female) and 4 460 086 served as controls (50.9% female). In the meta-analyses, patients with AD were 44% more likely to exhibit suicidal ideation (pooled odds ratio, 1.44; 95% CI, 1.25-1.65) and 36% more likely to attempt suicide (pooled odds ratio, 1.36; 95% CI, 1.09-1.70) compared with patients without AD. Studies investigating completed suicides in patients with AD had inconsistent results. CONCLUSIONS AND RELEVANCE Results of this study suggest that patients with AD are at significantly increased risk of suicidal ideation and suicide attempts. It is important for dermatology providers to be aware of this risk, screen for suicidality in patients with AD, and make mental health referrals when necessary.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association Between Atopic Dermatitis and Suicidality

Sandhu

Bui

et al. 2019

JAMA Dermatol

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“…25 Again, it is not surpris-ing that the appearance and symptoms of both skin diseases can have a negative effect on mental well-being and quality of life. 26,27 Despite the prevalence of suicidal thoughts in both psoriasis patients 28 and patients with atopic dermatitis, 23 a recent study by Thyssen et al 29 has shown that these patients undergo no psychiatric consultation or treatment.…”

Section: Discussionmentioning

confidence: 99%

Skin Diseases in Patients with Primary Psychiatric Disorders

Mavrogiorgou

Mersmann

Gerlach

et al. 2020

Psychiatry Investig

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Objective The few psychodermatological studies of primary psychiatric populations so far suggest that parasitic-infectious skin diseases are the most common dermatological comorbidity in more than 70% of psychiatric patients, which should be studied here in a large data bank outside dermatological treatment facilities.Methods In a descriptive-explorative and retrospective study, more than 17,000 patients with primary psychiatric disorders were examined to investigate dermatological comorbidities.Results The proportion of patients with primary mental disorders and additional dermatological disease was 1.24% (n=212). Here, psoriasis (35.4%) and atopic dermatitis (22.6%) were the most frequent dermatological diseases among these 212 patients. Infectious-parasitic skin diseases were present in 13.2% of comorbid patients. The most common mental disorder was a depressive illness, seen in 42.5% (n=90) of patients.Conclusion Our results confirmed the frequent association of depression with psoriasis and atopic dermatitis, indicating the need for the early detection and treatment of such comorbid patients. In contrast, psychiatric inpatients do not appear to suffer from predominantly infectious-parasitic dermatoses.

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“…17,24,31,32,41,42 Quality of life in patients with AD compared to healthy controls or other patient groups A total of 15 studies compared adults with AD QoL to that of healthy controls. Ten studies used generic QoL scales such as the SF-36 to enable comparison across groups, 19,[23][24][25]32,34,39,40,42,43 three studies used dermatology-specific QoL scales to make comparisons, 22,26,44 and three studies 34,36,45 used both generic and dermatology-specific scales. Overall QoL was significantly poorer in those with AD compared to healthy controls, and domains such as mental health and social functioning were affected to a greater extent in AD patients.…”

Section: Quality Of Life and Disease Severitymentioning

confidence: 99%

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

2020

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Atopic dermatitis (AD) can affect quality of life (QoL) of adult patients in whom the condition can be severe and persistent. There are currently no systematic reviews of the impact of AD on adults. This paper provides the first systematic literature review and meta‐analysis of the impact of AD on QoL in adults. A systematic search was conducted using MEDLINE, Scopus, and Web of Science for articles published until October 2018. Inclusion criteria were a clinical diagnosis of AD, adult patients, and QoL as an outcome measure. Interventions were excluded. A total of 32 studies were included. While QoL was assessed using Dermatology Life Quality Index (DLQI) in 25 studies, there was heterogeneity in the tools used to measure disease severity across studies. Meta‐analysis of the seven studies that used the SCORAD to measure disease severity showed severity to be significantly related to poorer QoL. The remaining 18 studies also showed increased disease severity significantly related to poorer QoL. When compared to healthy controls, AD patients demonstrated significantly lower QoL, but findings were mixed in studies that compared QoL in AD to other skin conditions. The findings highlight the significant impact that AD has on QoL in adults and the need for validated and relevant QoL measures to be implemented in clinical assessments for AD. Areas that require further research include an exploration of gender differences in QoL and the use of longitudinal study designs to explore factors that may cause differences in QoL ratings.

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Health-related Quality of Life and Mental Health of Adults With Atopic Dermatitis

Cited by 31 publications

References 33 publications

Association Between Atopic Dermatitis and Suicidality

Association Between Atopic Dermatitis and Suicidality

Skin Diseases in Patients with Primary Psychiatric Disorders

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

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