Health-related Quality of Life and Utilities in Gastric Premalignant Conditions and Malignant Lesions: a Multicentre Study in a High Prevalence Country

Areia, Miguel; Alves, Sara; Brito, Daniel; Cadime, Ana Teresa; Carvalho, Rita; Saraiva, Sandra; Ferreira, Sara; Moleiro, Joana; Pereira, António Dias; Carrasquinho, J; Lopes, Luís; Ramada, José María; Marcos-Pinto, Ricardo; Pedroto, Isabel; Contente, Luís; Eliseu, Liliana; Vieira, Ana Cristina; Sampaio, Margarida; Sousa, Helena Tavares de; Almeida, Nuno; Gregório, Carlos; Portela, Francisco; Sofia, Carlos; Braga, V.; Baginha, Elisabete; Costa, Tiago Bana e; Chagas, Cristina; Mendes, Luís Lebre; Magalhães-Costa, Pedro; Matos, Leopoldo; Gonçalves, Francisco Rocha; Dinis-Ribeiro, Mário

doi:10.15403/jgld.2014.1121.234.hrq

Cited by 21 publications

(20 citation statements)

References 48 publications

(27 reference statements)

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“…However, the utility weights obtained from a general population in the current study were generally lower than those obtained in previous studies of gastric cancer patients. In several studies, patients who underwent surgery for gastric cancer reported utility weights of 0.77 13 and 0.80 22 with EQ-5D and 0.85 23 with TTO. Moreover, a utility weight of 0.83 was reported for patients undergoing chemo/radiotherapy, 13 and a study of patients who had attended 2–4 chemotherapy sessions, conducted at ≥20 days after the last session, reported utility weights of 0.55 for EQ-5D, 0.61 for SF-6D, and 0.69 for 15D.…”

Section: Discussionmentioning

confidence: 99%

“…Although many studies have measured the utility weights of gastric cancer-related health states, these studies were restricted to health states associated with particular stages of gastric cancer and to the viewpoint of gastric cancer patients. 13 The present study aimed to determine the utility weights of gastric cancer-related health states across a wide range of stages and treatment strategies from the perspective of the general population, using SG.…”

Section: Introductionmentioning

confidence: 99%

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Estimation of population-based utility weights for gastric cancer-related health states

Lee¹,

Ock²,

Kim³

et al. 2018

PPA

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BackgroundThis study aimed to generate utility weights of gastric cancer-related health states from the perspective of the Korean general population.MethodsThe Korean adults (age ≥19 years) included in the study were sampled using multistage quota sampling methods stratified by sex, age, and education level. Nine scenarios for hypothetical gastric cancer-related health states were developed and reviewed. After consenting to participate, the subjects were surveyed by trained interviewers using a computer-assisted personal interview method. Participants were asked to perform standard gamble tasks to measure the utility weights of 5 randomly assigned health states (from among nine scenarios). The mean utility weight was calculated for each health state.ResultsThree hundred twenty-six of the 407 adults who completed this study were included in the analysis. The mean utility weights from the standard gamble were 0.857 (no gastric cancer with Helicobacter pylori infection), 0.773 (early gastric cancer [EGC] with endoscopic surgery), 0.779 (EGC with subtotal gastrectomy), 0.767 (EGC with total gastrectomy), 0.602 (advanced gastric cancer with subtotal gastrectomy and adjuvant chemotherapy), 0.643 (advanced gastric cancer with total gastrectomy and adjuvant chemotherapy), 0.522 (advanced gastric cancer with extended gastrectomy and adjuvant chemotherapy), 0.404 (metastatic gastric cancer with palliative chemotherapy), and 0.399 (recurrent gastric cancer with palliative chemotherapy).ConclusionThis study was the first to comprehensively estimate the utility weights of gastric cancer-related health states in a general population. The utility weights derived from this study could be useful for future economic evaluations related to gastric cancer interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estimation of population-based utility weights for gastric cancer-related health states

Lee¹,

Ock²,

Kim³

et al. 2018

PPA

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“…Regarding geographical locations, there appears to be a variation in the prevalence of this tumour, suggesting the relevance of the study within a locality. For instance, in Portugal, 10.3% of patients were found to have gastric adenocarcinoma out of a total of 1434 patients [ 14 ]. This was a typical illustration of variations in the prevalence of this tumour at a given place, hence the need for this study to present the pattern of the disease in Ghana and inform prompt attention.…”

Section: Discussionmentioning

confidence: 99%

HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana

Simpong

Asmah

Krampah

et al. 2018

The Scientific World Journal

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The prognosis of gastric and oesophageal adenocarcinoma remains generally poor. However, mounting evidence suggests a positive role of human epidermal growth factor receptor-2 (HER-2) expression in the prognosis of patients with these cancers. In this work, the patterns of HER-2 protein expression were determined in patients with gastric or oesophageal adenocarcinoma. Retrospectively, we reviewed records of gastric and oesophageal biopsies received from 2008 to 2012 and their corresponding archived formalin-fixed paraffin-embedded tissue blocks selected for immunohistochemical analysis. The prevalence of gastric and oesophageal adenocarcinomas and their association with HER-2 protein overexpression were evaluated. Gastric adenocarcinoma made up 18.79% of the gastric biopsies reviewed, and majority of these cancers occurred in males. Regarding the tumour type, HER-2 overexpression was common in the intestinal subtype compared to the diffuse type. Although squamous cell carcinoma was observed to be the commonest (31%) tumour type in the oesophagus compared to adenocarcinoma (8.79%), HER-2 was overexpressed in 42.9% of oesophageal adenocarcinomas, like gastric adenocarcinoma (41.4%). There is a high prevalence of gastric and oesophageal adenocarcinoma, with significant overexpression of HER-2 in these tumours, a window of hope for the management of patients with these cancers.

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“…The following four clinical states were included in this model to represent the possible clinical states in the target populations: (i) no H. pylori infection; (ii) H. pylori infection; (iii) gastric cancer; (iv) dead ( Fig. 2) [17]. Each cycle length was 1 year.…”

Section: Markov Modelsmentioning

confidence: 99%

“…A QALY is a year of life lived in perfect health and 0 QALY is death. Health state utilities were obtained from the literatures and were calculated by using a utility weight (Table 1) [17].…”

Section: Costs Probabilities Effectiveness Utilities and Other Assmentioning

confidence: 99%

Cost-effectiveness ofHelicobacter pyloriscreening followed by eradication treatment for employees in Japan

Kowada¹

2018

Epidemiol. Infect.

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Gastric cancer is the third leading cause of cancer death worldwide. Gastric cancer screening using upper gastrointestinal series, endoscopy and serological testing has been performed in population-based (employee-based and community-based) and opportunistic cancer screening in Japan. There were 45 531 gastric cancer deaths in 2016, with the low screening and detection rates. Helicobacter pylori (H. pylori) screening followed by eradication treatment is recommended in high-risk population settings to reduce gastric cancer incidence. The aim of this study was to evaluate the cost-effectiveness of H. pylori screening followed by eradication treatment for a high-risk population in the occupational health setting. Decision trees and Markov models were developed for two strategies; H. pylori antibody test (HPA) screening and no screening. Targeted populations were hypothetical cohorts of employees aged 20, 30, 40, 50 and 60 years using a company health payer perspective on a lifetime horizon. Per-person costs and effectiveness (quality-adjusted life-years) were calculated and compared. HPA screening yielded greater benefits at the lower cost than no screening. One-way and probabilistic sensitivity analyses using Monte-Carlo simulation showed strong robustness of the results. H. pylori screening followed by eradication treatment is recommended to prevent gastric cancer for employees in Japan, on the basis of cost-effectiveness.

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Health-related Quality of Life and Utilities in Gastric Premalignant Conditions and Malignant Lesions: a Multicentre Study in a High Prevalence Country

Cited by 21 publications

References 48 publications

Estimation of population-based utility weights for gastric cancer-related health states

Estimation of population-based utility weights for gastric cancer-related health states

HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana

Cost-effectiveness ofHelicobacter pyloriscreening followed by eradication treatment for employees in Japan

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