Health-related quality of life and functional status in end-stage COPD: a longitudinal study

Habraken, Jolanda M.; Wal, Willem M. van der; Riet, Gerben ter; Weersink, Els J.M.; Toben, F. M. J.; Bindels, P. J. E.

doi:10.1183/09031936.00149309

Cited by 43 publications

(49 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients with COPD have impaired disease-specific health status1 2 that may deteriorate over time 3. The St George's Respiratory Questionnaire (SGRQ) is a disease-specific health status questionnaire reflecting a broad variety of health impacts in patients with chronic respiratory diseases 4.…”

Section: Introductionmentioning

confidence: 99%

One-year change in health status and subsequent outcomes in COPD

Wilke

Jones

Müllerová

et al. 2015

Thorax

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

One-year change in health status and subsequent outcomes in COPD

Wilke

Jones

Müllerová

et al. 2015

Thorax

View full text Add to dashboard Cite

“…These data demonstrate that both functional capacity -maximum potential to develop an activity -and performance -daily activities performed -are able to reflect the impact that the impairment of activities of daily living has on the quality of life of patients with COPD. the most functionally impaired had greater impact on quality of life, especially in the domains 'activities' (25). Whereas the removal of an activity in daily life depends on the need and/or convenience and on the intensity of symptoms associated with it (5), these findings suggest that the functional status exerts greater impact on quality of life of patients in more advanced stages of the disease.…”

Section: Resultsmentioning

confidence: 98%

Relationship between the functional status constructs and quality of life in COPD

et al. 2014

View full text Add to dashboard Cite

Introduction: Functional status is an important component of health related quality of life (QOL) in patients with chronic obstructive pulmonary disease (COPD). However there is a lack of studies aiming to evaluate the association between QOL and the different methods for assessing patient´s limitation to perform ADL. Objectives: To investigate the association between QOL and functional status, measured by four different instruments: London Chest Activity of Daily Living scale (LCADL), six-minute walking test (6MWT), Glittre ADL-test (TGlittre) and assessment of physical activities in daily living (PADL). Methods: Twenty-three patients with COPD, GOLD 2 to 4, were submitted to the following evaluations: spirometry, the Saint George Respiratory Questionnaire (SGRQ), LCADL, 6MWT, TGlittre and assessment of PADL. Pearson or Spearman correlation coefficients were used to verify the association between the variables. Results: It was observed correlation between all domains of the SGRQ and the 6MWT, between TGlittre and 'leisure' domain of LCADL; and between the domain 'activity' of the SGRQ with the total score of LCADL (r = 0.53), LCADL% (r =

show abstract

“…Most of these studies focused on HRQL changes of hospitalized patients (e.g. during acute exacerbations [33,34]), newly detected COPD cases [35], patients in the end-stage setting [15] or observed HRQL changes after pharmacological and non-pharmacological interventions [13,14]. In general, weak associations between changes in lung function and HRQL developments were found [36,37].…”

Section: Discussionmentioning

confidence: 99%

“…Most studies focus on HRQL changes after pharmacological and non-pharmacological interventions in selected patients groups [13-15]. …”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life and chronic obstructive pulmonary disease in early stages – longitudinal results from the population-based KORA cohort in a working age population

et al. 2014

View full text Add to dashboard Cite

BackgroundIt is widely recognized that health-related quality of life (HRQL) is impaired in patients with Chronic Obstructive Pulmonary Disease (COPD), but there is a lack of research on longitudinal associations of COPD and HRQL. This study examined the effects of COPD in early stages of disease on HRQL over ten years in a working-age general population setting in Southern Germany while considering the influence of common comorbidities.MethodsIn the population-based KORA F4 study (2006–08) 1,321 participants aged 41–61 years performed spirometry and reported information on HRQL (measured by the generic SF-12) and comorbidities. For the same participants, HRQL information was available seven years before and three years after the lung function test from the previous S4 (1999–2001) and the F4L follow-up study (2010). Using linear mixed models, the physical and mental component summary scores (PCS-12 / MCS-12) of the SF-12 were compared over time between COPD groups.Results7.8% of participants were classified as having COPD (according to the LLN definition and the Global Lungs Initiative), 59.4% of them in grade 1. Regression models showed a negative cross-sectional association of COPD grade 2+ with PCS-12 which persisted when comorbidities were considered. Adjusted mean PCS-12 scores for the COPD grade 2+ group were reduced (−3.5 (p = 0.008) in F4, −3.3 (p = 0.014) in S4 and −4.7 (p = 0.003) in F4L) compared to the group without airflow limitation. The size of the COPD effect in grade 2+ was similar to the effect of myocardial infarction and cancer. Over ten years, a small decline in PCS-12 was observed in all groups. This decline was larger in participants with COPD grade 2+, but insignificant. Regarding MCS-12, no significant cross-sectional or longitudinal associations with COPD were found.ConclusionDespite small HRQL differences between COPD patients in early disease stages and controls and small changes over ten years, our results indicate that it is important to prevent subjects with airflow limitation from progression to higher grades. Awareness of HRQL impairments in early stages is important for offering early interventions in order to maintain high HRQL in COPD patients.

show abstract

Health-related quality of life and functional status in end-stage COPD: a longitudinal study

Cited by 43 publications

References 37 publications

One-year change in health status and subsequent outcomes in COPD

One-year change in health status and subsequent outcomes in COPD

Relationship between the functional status constructs and quality of life in COPD

Health-related quality of life and chronic obstructive pulmonary disease in early stages – longitudinal results from the population-based KORA cohort in a working age population

Contact Info

Product

Resources

About