“…Upper extremity injury was also found to be a predictor for worse HRQoL, more disability, and reduced return to work in some studies [ 31 , 142 , 156 ], especially when the brachial plexus was injured [ 71 ]. Although some studies ( n = 10) indicated no (significant) correlation between (the severity of) head and/or neurological injuries and HRQoL [ 29 , 38 , 46 , 48 , 63 , 65 , 67 , 86 , 138 , 142 ], the majority (n = 16) of publications did [ 31 , 36 , 37 , 42 , 43 , 48 , 54 , 55 , 60 , 64 , 66 , 68 , 69 , 74 , 136 , 155 ]; especially mental and cognitive function were affected as well as the pain domain [ 36 , 43 , 48 , 54 , 55 , 64 , 66 , 69 , 156 ], with an initial lower Glasgow Coma Scale (GCS) predicting worse HRQoL [ 60 , 68 , 69 ]. GCS appeared to be a reliable predictor of HRQoL in some populations [ 60 , 68 ], and was negatively associated with self-reported physical health.…”