Health-related quality of life among disease-free stomach cancer survivors in Korea

Bae, Jae-Moon; Kim, Sung Hoon; Kim, Young Woo; Ryu, Keun Won; Lee, Jun Ho; Noh, Jae Hyung; Sohn, Tae-Sung; Hong, Seong‐Kwan; Park, Sang Min; You, Chang Hoon; Kim, Jung Hee; Lee, Myung Kyung; Yun, Young Ho

doi:10.1007/s11136-006-9000-8

Cited by 62 publications

(33 citation statements)

References 29 publications

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“…The association between postprandial symptoms and overly rapid drainage of the stomach was first described by Hertz [13], and the term ‘dumping' was introduced by Mix [14]. Many investigators have reported relationships between gastrectomy type and dumping syndrome [15,16,17,18,19,20,21,22,23], but most such studies were small and focused on only a few types of surgical procedures for gastric cancer. A large-scale study on dumping syndrome after gastrectomy was recently reported [24].…”

Section: Discussionmentioning

confidence: 99%

Specific Features of Dumping Syndrome after Various Types of Gastrectomy as Assessed by a Newly Developed Integrated Questionnaire, the PGSAS-45

et al. 2015

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Aim: Dumping syndrome is a well-known adverse outcome after gastrectomy, but the precise clinical features have not been described. The aim of this study was to examine global aspects of dumping syndrome and to explore factors affecting the intensity of dumping syndrome in a large cohort using a newly developed integrated questionnaire, the Post-Gastrectomy Syndrome Assessment Scale (PGSAS)-45. Methods: Eligible questionnaires retrieved from 2,368 patients after 6 types of gastrectomy were analyzed. The incidence, intensity and number of symptoms of early general, early abdominal and late dumping syndrome were examined across various types of gastrectomy, and clinical factors affecting the intensity of each category of dumping syndrome were identified by multiple regression analysis. Results: Dumping syndromes occurred most frequently and strongly in patients who underwent total gastrectomy with Roux-en-Y (TGRY), followed by proximal gastrectomy (PG), distal gastrectomy with Billroth-I, distal gastrectomy with Roux-en-Y, pylorus-preserving gastrectomy (PPG) and local resection (LR), in that order. Significant positive correlations among different categories of dumping syndromes were observed. TGRY, female sex, younger age, division of the celiac branch of the vagus nerve, PG and shorter postoperative period were independently related to worse dumping syndrome. Conclusions: Dumping syndromes were most common after TGRY and least common after PPG and LR among the various gastrectomy procedures. Type of gastrectomy and several clinical factors were related to the intensity of dumping syndrome. PGSAS-45 could offer a useful tool for evaluating dumping syndrome after gastrectomy.

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Section: Discussionmentioning

confidence: 99%

Specific Features of Dumping Syndrome after Various Types of Gastrectomy as Assessed by a Newly Developed Integrated Questionnaire, the PGSAS-45

et al. 2015

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“…The largest studies to date have been cross-sectional, assessing QOL in patients from six months to five years following gastric resection 5, 6, 8, 9 . These well-powered studies concluded that some patients have impaired QOL after curative gastrectomy.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life After Gastrectomy for Adenocarcinoma

et al. 2013

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Background Gastrectomy remains a major operation with potential for significant deterioration in patients’ health-related quality of life (QOL). This study assessed differences in QOL among patients following distal (DG), proximal (PG) or total (TG) gastrectomy. Methods We prospectively enrolled patients undergoing gastrectomy at our institution between 2002 and 2007. Participants completed the EORTC cancer (QLQ-C30) and gastric (QLQ-STO22) questionnaires preoperatively and at five postoperative intervals up to 18 months. We compared changes from baseline in patients based on extent of resection (proximal, distal, or total) using generalized linear models, adjusting for age, stage of disease, and (neo)adjuvant therapy. We converted QOL raw scores to reflect the proportion of patients with clinically significant deterioration based on the minimal important difference (MID). Results We included 134 patients: 82 DG, 16 PG, and 36 TG. In the immediate postoperative period, 55% of patients suffered significant impairment in their global QOL. This improved in most patients by six months, although 20-35% continued to have substantially worse QOL than prior to surgery. Patients who underwent PG suffered from significantly more clinical reflux (70% vs 35% (DG), 40% (TG)), nausea/vomiting (60% vs 25%, 30%), and global QOL impairment (60% vs 30%, 30%) than DG or TG patients, whose QOL scores were similar. These differences persisted up to 18 months postoperatively. Conclusions Surgeons should discuss expectations of QOL impairment with their patients prior to gastrectomy and reassure them that most symptoms resolve by six months following operation. Patients who undergo PG suffer from worse QOL impairment than patients who undergo DG or TG.

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“…Comorbidities are important factors in the QoL of survivors of a variety of primary cancers [7, 39, 40]. In this study, we focused on the role of specific comorbidities in the QoL of the cervical cancer survivors.…”

Section: Discussionmentioning

confidence: 99%

Comorbidity in Disease-Free Survivors of Cervical Cancer Compared with the General Female Population

Shin¹,

Nam

Kwon³

et al. 2008

Oncology

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Objectives: We aimed to investigate the prevalence of comorbidities in cervical cancer survivors compared with the general population and to identify risk factors and impact on their quality of life (QoL). Methods: 860 female cervical cancer survivors enrolled at six tertiary hospitals and 994 women from the general population were surveyed on current comorbidities and QoL (EORTC QLQ-C30 and QLQ-CX24). Results: Compared with the general female population, the cervical cancer survivors reported higher prevalence of comorbidities (0.93 ± 2.91 vs. 0.37 ± 0.67, p < 0.01), significantly more heart disease (adjusted odds ratio (aOR), 2.64; 95% confidence interval (CI), 1.38–5.07), liver disease (aOR, 3.29; 95% CI, 1.54–7.02), hypertension (aOR, 1.72; 95% CI, 1.30–2.27), gastrointestinal disease (aOR, 1.79; 95% CI, 1.37–2.33) and musculoskeletal disease (aOR, 1.94; 95% CI, 1.45–2.59). Heart and renal disease significantly influenced QoL in many subscales. Patients with diabetes or cerebrovascular disease had an increased likelihood of sexual problems. Conclusions: The cervical cancer survivors had more comorbidities than the general population, and that in turn affected their QoL. Vigilant follow-up of comorbidities should be incorporated into in the care of cancer survivors.

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Health-related quality of life among disease-free stomach cancer survivors in Korea

Cited by 62 publications

References 29 publications

Specific Features of Dumping Syndrome after Various Types of Gastrectomy as Assessed by a Newly Developed Integrated Questionnaire, the PGSAS-45

Specific Features of Dumping Syndrome after Various Types of Gastrectomy as Assessed by a Newly Developed Integrated Questionnaire, the PGSAS-45

Quality of Life After Gastrectomy for Adenocarcinoma

Comorbidity in Disease-Free Survivors of Cervical Cancer Compared with the General Female Population

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