Health-related quality of life among adults with symptoms of overactive bladder: results from a U.S. community-based survey

Liberman, Joshua N.; Hunt, Timothy; Stewart, Walter F.; Wein, Alan J.; Zhou, Zhiyuan; Herzog, A. Regula; Lipton, Richard B.; Diokno, Ananias C.

doi:10.1016/s0090-4295(01)00986-4

Cited by 228 publications

(136 citation statements)

References 18 publications

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“…Moreover, women with GSI or OAB syndrome show an increased tendency to be depressed due to their voiding problems. 27,28 Based on this fact, we suggest that a lack of self-confidence and a negative body image due to voiding symptoms are secondary causes of a subdued sexual life and the avoidance of sexual activity.…”

Section: Discussionmentioning

confidence: 94%

The effect of overactive bladder syndrome on the sexual quality of life in Korean young and middle aged women

2004

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Some reports showed that urinary incontinence (UI) or female lower urinary tract symptoms (LUTS) affect life quality and sexual activity. In clinical practice, it is commonly found that not only the symptoms of UI but also overactive bladder (OAB) syndrome affect daily lifestyle and sexual activity, especially in women in the most active era in their social and personal life. However, there is lack of data proving the effect of OAB syndrome on sexual activity or sexual life quality in sexually active age group. This study aimed at evaluating the effect of OAB syndrome and UI on the sexual activity and on the sexual quality of life (QoL) of Korean women age from 20s to 40s. We investigated 3372 women aged between 20 and 49 y, enrolled via a multicenter internet survey. A structured questionnaire was used to collect data about their LUTS and sexual activities. The prevalence of OAB syndrome and UI in 3372 women was 12.7 and 21.0%, respectively. Mean subject age was 26.474.8 y and 79.5% of subjects were 20-29 y old. Having OAB syndrome or UI were found to be significant predictors of sexual life problems (OAB syndrome: OR ¼ 5.08, 95% CI ¼ 3.68-7.01; UI: OR ¼ 4.16, 95% CI ¼ 3.06-5.67). Sexual activity was significantly reduced in OAB syndrome and UI versus the asymptomatic group (OAB syndrome: OR ¼ 4.8, 95% CI ¼ 3.14-6.83; UI: OR ¼ 3.9, 95% CI ¼ 2. 81-5.27). This study is the first internet-based study concerning the sexual QoL in UI and OAB syndrome. In this study, OAB syndrome was found to cause a greater deterioration in the sexual QoL than UI. These results suggest that these symptoms have a significant impact upon women's personal and social lives and markedly affect the QoL.

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Section: Discussionmentioning

confidence: 94%

The effect of overactive bladder syndrome on the sexual quality of life in Korean young and middle aged women

2004

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“…Urge incontinence may occur if intravesical pressure exceeds urethral closure pressure and is present in 30-50% of people with OAB [Appell et al 2001, Latifpour et al 1992, Liberman et al 2001. Health care estimates for the cost of urinary incontinence in the USA exceed 26.3 billion dollars in 1995 [Wagner et al 1998].…”

Section: Introductionmentioning

confidence: 99%

Direct inhibition of rat detrusor muscle contraction by erythromycin

England¹,

Norman²,

Elliott³

2004

Neurourology and Urodynamics

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PurposeDetrusor instability is a common problem in the elderly, which is usually treated with anti-cholinergic medication. This study investigates the effect of erythromycin on rat detrusor muscle contractile response to characterise its potential as an alternative inhibitor of bladder muscle contraction. Materials and MethodsStrips of rat detrusor muscle were suspended in a perfusion organ bath. The ResultsErythromycin 5 × 10 -4 M inhibited the maximum contractile response to EFS, carbachol and potassium by 38% (p<0.01), 62% (p<0.001) and 17% (p<0.05)respectively, but did not significantly reduce the response to direct muscle stimulation. The atropine-resistant component of EFS-evoked contraction was inhibited by 19.5% (p<0.01) in the presence of erythromycin. In calcium-free Krebs solution, the maximum contractile response to carbachol was reduced by 42% of control (p<0.0001) and nifedipine 10 -8 M had no additional effect. When erythromycin 5 × 10 -4 M was added together with nifedipine 10 -8 M, the response to carbachol was inhibited by a further 25% (p<0.005). ConclusionsErythromycin inhibits rat detrusor muscle contraction through the inhibition of calcium influx and the modulation of intracellular calcium movement.

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“…[29] Because cognitive function is not routinely evaluated by practitioners treating OAB, the true rate of cognitive impairment associated with anticholinergic use is unknown. [4] Evaluation of baseline urinary symptoms in our clinic population demonstrated that most women are severely affected by OAB and have tried at least one prior anticholinergic medication prior to seeking care with a specialist. This may be helpful in understanding baseline disease severity in women seeking specialty care for management of OAB.…”

Section: Discussionmentioning

confidence: 99%

“…[1,2] OAB has farreaching consequences for both physical and mental health: skin breakdown due to leakage, sleep disturbance, fall-related injuries, depression, prolonged hospital stays, admission to a nursing home and lower quality of life. [1,[3][4][5] OAB is an embarrassing condition that interferes with not only social functioning but also a wide range of activities of daily living. [4 ] Annual direct costs of OAB in the US --including diagnostic tests, physician visits, medications, treatment procedures, supplies such as pads, diapers and home care --totaled over $12 billion in 2005.…”

Section: Introductionmentioning

confidence: 99%

“…[1,[3][4][5] OAB is an embarrassing condition that interferes with not only social functioning but also a wide range of activities of daily living. [4 ] Annual direct costs of OAB in the US --including diagnostic tests, physician visits, medications, treatment procedures, supplies such as pads, diapers and home care --totaled over $12 billion in 2005. [6 ] This is comparable to breast cancer ($12.7 billion) and osteoporosis ($13.8 billion).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Anticholinergic Use for the Treatment of Overactive Bladder on Cognitive Function in Postmenopausal Women

et al. 2012

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Health-related quality of life among adults with symptoms of overactive bladder: results from a U.S. community-based survey

Cited by 228 publications

References 18 publications

The effect of overactive bladder syndrome on the sexual quality of life in Korean young and middle aged women

The effect of overactive bladder syndrome on the sexual quality of life in Korean young and middle aged women

Direct inhibition of rat detrusor muscle contraction by erythromycin

Effect of Anticholinergic Use for the Treatment of Overactive Bladder on Cognitive Function in Postmenopausal Women

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