Health-related quality of life after pancreatic resection for malignancy

Heerkens, H.D.; Tseng, Dorine S.J.; Lips, Irene M.; Santvoort, Hjalmar C. van; Vriens, Menno R.; Hagendoorn, Jeroen; Meijer, G.J.; Rinkes, Inne H.M. Borel; Vulpen, Marco van; Molenaar, I. Quintus

doi:10.1002/bjs.10032

Cited by 63 publications

(79 citation statements)

References 27 publications

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“…Based on SEER-18, for 96.8% of unresected patients, resection was not recommended by clinicians. QoL decreases considerably in the early postoperative phase and its full recovery might take up to half a year 45. However, overall resection does not worsen and even benefits QoL in most PaC survivors in the longer term 46…”

Section: Discussionmentioning

confidence: 99%

Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations

Huang

Jansen

Balavarca

et al. 2017

Gut

163

121

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Section: Discussionmentioning

confidence: 99%

Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations

Huang

Jansen

Balavarca

et al. 2017

Gut

163

121

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“…17,18 Indeed, QOL after abdominal procedures decreases considerably in the early postoperative phase, and that full recovery is achieved up to 6 months after surgery. 2,4,15,19 …”

Section: Introductionmentioning

confidence: 99%

Wireless Monitoring Program of Patient-Centered Outcomes and Recovery Before and After Major Abdominal Cancer Surgery

et al. 2017

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Importance A combined objective and subjective wireless monitoring program of patient-centered outcomes can be carried out in patients before and after major abdominal surgery. Objective To conduct a proof-of-concept study of a wireless, patient-centered outcomes monitoring program before and after major abdominal cancer surgery. Design Patients wore wristband pedometers and completed online patient-reported outcome surveys (symptoms, QOL) 3 to 7 days before surgery, through hospitalization, and for two weeks post-discharge. Alerts were generated for all moderate to severe scores for symptoms and QOL. Surgery-related data was collected via electronic medical chart and complications were calculated using the Clavien-Dindo classification. Setting The study was carried out in the inpatient and outpatient surgical oncology unit of one NCI designated comprehensive cancer center. Participants Eligible patients were scheduled to undergo curative resection for hepatobiliary and gastrointestinal malignancies, English-speaking, and 18 years or older. Twenty participants were enrolled over 4 months. Main Outcomes and Measures Outcomes included 1) adherence with wearing the pedometer; 2) adherence with completing the surveys (MDASI and EQ-5D-5L), and 3) satisfaction with the monitoring program. Results Pedometer adherence (88% pre-op versus 83% post-discharge) was higher than survey adherence (75% completed). The median number of steps at day 7 was 1689 (19% of steps at baseline). This correlated with the comprehensive complication index (CCI), for which the median was 15/100 (r = −0.64, p<0.05). Post-discharge overall symptom severity (2.3/10) and symptom interference with activities (3.5/10) were mild. Pain, fatigue, and appetite loss were moderate after surgery (4.4, 4.7, 4.0). QOL scores were lowest at discharge (66.6/100), but improved at week 2 (73.9/100). While patient-reported outcomes returned to baseline at 2 weeks, the number of steps was only one third of pre-operative baseline. Conclusions and Relevance Wireless monitoring of combined subjective and objective patient-centered outcomes can be carried out in the surgical oncology setting. Pre- and post-operative patient-centered outcomes have the potential of identifying high risk populations who may need additional interventions to support postoperative functional and symptom recovery.

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“…Previous studies have shown that in the period 1-3 months after major pancreatic operations, there is an obvious decrease in QoL. [3][4][5][6] It takes 3-6 months for QoL to fully recover after surgery. 3,[5][6][7] Literature has reported negative effects of complications on QoL in oesophageal and (colo)rectal cancer.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6] It takes 3-6 months for QoL to fully recover after surgery. 3,[5][6][7] Literature has reported negative effects of complications on QoL in oesophageal and (colo)rectal cancer. [8][9][10] Complications might also influence QoL in patients with pancreatic cancer.…”

Section: Introductionmentioning

confidence: 99%

Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications

Heerkens

Berkel

Tseng

et al. 2018

HPB

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Health-related quality of life after pancreatic resection for malignancy

Abstract: QoL after pancreatic resection for malignant and premalignant tumours decreased considerably in the early postoperative phase. Full recovery of QoL took up to 6 months after the operation.

Cited by 63 publications

References 27 publications

Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations

Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations

Wireless Monitoring Program of Patient-Centered Outcomes and Recovery Before and After Major Abdominal Cancer Surgery

Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications

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