Health related quality of life in patients with chronic gastritis and peptic ulcer and factors with impact: a longitudinal study

Zhang, Wen; Li, Xiaomei; Lü, Qian; Brunson, Julie A.; Zhao, Miao; Tan, Jianfeng; Wan, Chonghua; Lei, Pingguang

doi:10.1186/1471-230x-14-149

Cited by 30 publications

(31 citation statements)

References 29 publications

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“…Studies conducted on adults with gastrointestinal diseases, such as peptic ulcers and gastroesophageal reflux, have reported lower life quality scores than the normal population, but also found significantly increased life quality scores after the treatment (26,27). A study on adults showed that patients with chronic gastritis had lower average scores when compared to those patients with peptic ulcers in all the life quality subscales, except for the physical functioning scale score (10). When compared with the normal population, both groups of patients had lower qualities of life scores (10).…”

Section: Discussionmentioning

confidence: 99%

“…Gastritis can affect an individual's daily activities, and this creates an important health problem from both the social and economic points of view. Gastritis may lead to an observable worsening in the quality of life (QoL) and affect the quality of sleep for adult patients (10,11). There are no studies in the contemporary international literature that are focused on the quality of sleep and life in children and adolescents with gastritis.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Chronic Gastritis on Sleep and Quality of Life in Adolescents

Appak¹,

Özyurt²,

Karakoyun³

et al. 2019

jpr

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This study aims to evaluate the sleep quality and the quality of life (QoL) of adolescents with chronic gastritis, and determine the related factors. Materials and Methods: This study included patients who were diagnosed with chronic gastritis both clinically and histopathologically. The Pittsburgh Sleep Quality Index and Epworth Sleepiness scale were used to assess sleep quality, and the Pediatric Quality of Life Inventory was used to assess QoL. The control group included healthy volunteers with no chronic diseases and no gastrointestinal system complaints. Results: Fifty-six patients with gastritis and 55 healthy volunteers were included. The patients with gastritis were found to have significantly lower overall QoL subscale, and total scale scores, except for the social functioning total score. Except for the subjective sleep quality, significant differences were seen between the groups in the sleep quality subscale, total scale, and sleepiness scale averages. The total score of the sleep quality scale was significantly higher in patients who had lower incomes than expenditure. There were no significant differences between the obese or overweight patients with gastritis and the rest of the gastritis patients in the study sample. There were no significant differences found between the Helicobacter pylori positive and negative gastritis patients in terms of the total QoL and sleepiness scale scores. Conclusion: This study is important because it is the first study in adolescents in this respect. The sleep and QoL scores of those adolescents with chronic gastritis were lower than the control group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Chronic Gastritis on Sleep and Quality of Life in Adolescents

Appak¹,

Özyurt²,

Karakoyun³

et al. 2019

jpr

View full text Add to dashboard Cite

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“…Wen et al (2014) also reported that patients with chronic gastritis had poor QOL compared to patients with peptic ulcers (except for PF domain), and both groups had lower QOL score compared to population norms (except for MH domain). After treatment, both groups experienced improved QOL after treatments (except for RP domain for both diseases) [27] . In a recent study by Kabakambira et al (2018) evaluated the impact of HR QOL using the Short Form Nepean Dyspepsia Index (SF-NDI) questionnnaire of PUD patients on standard antibiotic based triple therapy for 10 days, the improvement was much less in the metronidazole-based triple therapy than in the standard of care [28] .…”

Section: Assessment Of Qol Of Pud Patients On H Pylori Eradication Tmentioning

confidence: 96%

The Effect of Probiotic Supplement as Adjuvant Therapy on Dyspeptic Symptoms and Quality of Life during Helicobacter pylori Eradication Therapy in a Sample of Iraqi Patients with Peptic Ulcer Disease

2018

AJPS

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Infection with Helicobacter pylori (H. pylori) had been associated with development of certain symptoms in addition to the use of standard eradication triple therapy has resulted in the increased incidence of undesirable side effects, which can lead to reduced compliance. Probiotics have been proposed to contribute to their efficacy in increasing H. pylori eradication and decreasing side effects when used together with eradication therapy. This study was intended to minimize the side effects of antibiotics therapy and the symptoms associated with peptic ulcer disease (PUD) and improving patient's quality of life (QOL). This interventional prospective randomized- controlled, open-label study was carried out on 77 patients diagnosed with positive H. pylori infection during the period from September 2017 to April 2018. The incidence and intensity of symptom score that caused by adverse effects of both infection and therapy were highly significantly decrease in terms of epigastric pain, bloating, flatulence, taste disturbance, loss of appetite, nausea, vomiting, and heartburn after 2 months of treatment within each study group correspondingly all domains of the quality of life were significantly improved in all patients after H. pylori eradication within each study group. From the present study concluded that the administra¬tion of probiotics as adjuvant to standard triple therapy may suggest a role in improving the symptoms and reduce the adverse effects accompanying with the eradication therapy for H. pylori thus improving patient's quality of life.

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“…It is well known that alcohol abuse may cause acute erosive hemorrhagic gastritis, and long-term drinking could cause stomach disorders and chronic atrophic gastritis [5][6][7]. In general, gastritis is mainly due to the imbalance between aggressive and defensive factors of the gastric mucosa, which causes a variety of issues, from local defects to active inflammation [8][9][10][11]. This kind of chronic inflammation is increasingly recognized to have significant tumor-promoting potential [12,13].…”

Section: Introductionmentioning

confidence: 99%

A New Participant in the Pathogenesis of Alcoholic Gastritis: Pyroptosis

Zhu

Cao

et al. 2018

Cell Physiol Biochem

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Background/Aims: Alcohol abuse exerts deleterious effects on the internal organs of the body, and alcohol-related gastritis is a common disease for which prompt treatment is essential to prevent the condition from growing worse. However, the therapeutic methods have some adverse effects. Determining the pathogenic mechanisms of alcoholic gastritis is therefore essential. Methods: The MTT assay was developed in order to determine the optimal concentration of alcohol needed to treat gastric mucosal cells. The effects of alcohol on the gastric mucosal cells were determined by qRT-PCR and western blot. The release of IL-1β and IL-18 were determined by ELISA assay. The immunofluorescence assay was used to detect caspase-1 activation levels, while immunohistochemical assay and HE staining were performed to identify the effectiveness of the caspase-1 inhibitor on alcoholic gastritis. The TUNEL assay was used to determine DNA fragmentation. Results: Here, we clarified that ethanol treatment could cause cell DNA damage, activate caspase-1, and promote the generation and release of IL-1β and IL-18. In other words, ethanol could induce pyroptosis. Interestingly, a caspase-1 inhibitor could significantly suppress pyroptosis, decrease the release of inflammatory cytokines induced by ethanol, and cause no side effects in vivo and in vitro. Conclusion: Collectively, our results showed that pyroptosis is involved in the pathogenesis of alcohol-induced gastritis and that caspase-1 inhibitor Ac-yvad-cmk could effectively decrease the damage caused by alcohol, making it a potentially promising agent for the treatment of alcoholic gastritis.

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Health related quality of life in patients with chronic gastritis and peptic ulcer and factors with impact: a longitudinal study

Cited by 30 publications

References 29 publications

Effects of Chronic Gastritis on Sleep and Quality of Life in Adolescents

Effects of Chronic Gastritis on Sleep and Quality of Life in Adolescents

The Effect of Probiotic Supplement as Adjuvant Therapy on Dyspeptic Symptoms and Quality of Life during Helicobacter pylori Eradication Therapy in a Sample of Iraqi Patients with Peptic Ulcer Disease

A New Participant in the Pathogenesis of Alcoholic Gastritis: Pyroptosis

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