Health-promoting properties of <i>Saccharomyces cerevisiae var. boulardii</i> as a probiotic; characteristics, isolation, and applications in dairy products

Ansari, Fereshteh; Samakkhah, Shohreh Alian; Bahadori, Ali; Jafari, Seyedeh Maedeh; Ziaee, Mojtaba; Khodayari, Mohammad Taghi; Pourjafar, Hadi

doi:10.1080/10408398.2021.1949577

Cited by 43 publications

(26 citation statements)

References 225 publications

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“…boulardii showed significant modulation in the host early immune response, through this, the host body can show resistance against most microbial communities. It can also keep the equilibrium between pro and anti-inflammatory immune responses by the upregulation of several cytokines and inhibit the immune cell proliferation and maturation [ 8 ].…”

Section: Clinical Significance Of S Cerevisiae Var...mentioning

confidence: 99%

“…boulardii is used preferably due to its unique digestible properties of starch and proteins. Reduction in trypsin-inhibitor activity and phytic acid content is responsible for its digestible behavior [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…3 µm thickness and 2.5–10.5 µm length. This yeast is able to reproduce sexually and asexually by budding and unification [ 8 ]. The cell wall of S. cerevisiae var.…”

Section: Introductionmentioning

confidence: 99%

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Probiotic Yeast Saccharomyces: Back to Nature to Improve Human Health

Abid¹,

Waseem

Ali

et al. 2022

JoF

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Saccharomyces cerevisiae var. boulardii is best known for its treatment efficacy against different gastrointestinal diseases. This probiotic yeast can significantly protect the normal microbiota of the human gut and inhibit the pathogenicity of different diarrheal infections. Several clinical investigations have declared S. cerevisiae var. boulardii a biotherapeutic agent due to its antibacterial, antiviral, anti-carcinogenic, antioxidant, anti-inflammatory and immune-modulatory properties. Oral or intramuscular administration of S. cerevisiae var. boulardii can remarkably induce health-promoting effects in the host body. Different intrinsic and extrinsic factors are responsible for its efficacy against acute and chronic gut-associated diseases. This review will discuss the clinical and beneficial effects of S. cerevisiae var. boulardii in the treatment and prevention of different metabolic diseases and highlight some of its health-promising properties. This review article will provide fundamental insights for new avenues in the fields of biotherapeutics, antimicrobial resistance and one health.

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Section: Clinical Significance Of S Cerevisiae Var...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Probiotic Yeast Saccharomyces: Back to Nature to Improve Human Health

Abid¹,

Waseem

Ali

et al. 2022

JoF

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“…Saccharomyces cerevisiae var. boulardii which is anti-carcinogenic, antibacterial antiviral, antioxidant, and able to reduce serum cholesterol level, has been used for treating various gut-related diseases ( 88 ). Saccharomyces boulardii administration attenuates acute liver injury ( 89 ).…”

Section: Treatmentsmentioning

confidence: 99%

The Role of Gut Bacteria and Fungi in Alcohol-Associated Liver Disease

et al. 2022

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Cirrhosis and liver cancer caused by alcohol-associated liver disease (ALD) are serious threats to people's health. In addition to hepatic cell apoptosis and liver inflammation caused by oxidative stress during alcohol metabolism, intestinal microbiota disorders are also involved in the onset and development of ALD. Ethanol and its' oxidative and non-oxidative metabolites, together with dysbiosis-caused-inflammation, destroys the intestinal barrier. Changes of several microbial metabolites, such as bile acids, short-chain fatty acids, and amino acid, are closely associated with gut dysbiosis in ALD. The alcohol-caused dysbiosis can further influence intestinal barrier-related proteins, such as mucin2, bile acid-related receptors, and aryl hydrocarbon receptor (AhR), and these abnormal changes also participate in the injury of the intestinal barrier and hepatic steatosis. Gut-derived bacteria, fungi, and their toxins, such as lipopolysaccharide (LPS) and β-glucan translocate into the liver through the damaged intestinal barrier and promote the progression of inflammation and fibrosis of ALD. Thus, the prevention of alcohol-induced disruption of intestinal permeability has a beneficial effect on ALD. Currently, multiple therapeutic treatments have been applied to restore the gut microbiota of patients with ALD. Fecal microbial transplantation, probiotics, antibiotics, and many other elements has already shown their ability of restoring the gut microbiota. Targeted approaches, such as using bacteriophages to remove cytolytic Enterococcus faecalis, and supplement with Lactobacillus, Bifidobacterium, or boulardii are also powerful therapeutic options for ALD.

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“…The most commonly used probiotics include strains of the Bifidobacterium and Lactobacillus genera ( Vlasova et al, 2016 ). Some fungal strains belonging to Saccharomyces have also been used in probiotic formulations ( Ansari et al, 2021 ). Probiotics are traditionally added to dairy products, such as cheeses ( Sharifi et al, 2021 ), yogurts ( Afzaal et al, 2019 ), and milk ( Abesinghe et al, 2020 ), but recently non-dairy products, such as meats, bread, juices, and chocolates have also been explored as probiotic delivery matrices ( Aspri et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%