Health Problems in Adolescents With Alcohol Use Disorders: Self-Report, Liver Injury, and Physical Examination Findings and Correlates

Clark, Duncan B.; Lynch, Kevin G.; Donovan, James M.; Block, Geoffrey D.

doi:10.1097/00000374-200109000-00016

Cited by 16 publications

(16 citation statements)

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“…We examined overall functioning from clinical scores on the Global Assessment of Function (GAF). Because symptoms of disturbed sleep and anxiety can represent distinct subtypes of major depression (Moritz et al, 2004),(Fawcett et al, 1990) and substance use disorders (Clark et al, 2001), we examined sleep disturbance and maternal anxiety subscales (Moritz et al, 2004),(Fawcett et al, 1990) from the SIGH-ADS and EPDS measures. For sleep disturbance we examined the SIGH-ADS sleep items on early, middle and late insomnia (items H6, H7 and H8), hypersomnia (item A6) and wake time after sleep onset (WASO) more than 20 minutes.…”

Section: Methodsmentioning

confidence: 99%

“…For sleep disturbance we examined the SIGH-ADS sleep items on early, middle and late insomnia (items H6, H7 and H8), hypersomnia (item A6) and wake time after sleep onset (WASO) more than 20 minutes. We constructed a categorical measure of insomnia (score of 2 on any of the 3 insomnia items), and a composite 6-point subscale for sleep (Clark et al, 2001; Fawcett et al, 1990) comprised of the SIGH-ADS sleep items plus EPDS item 7 “I’ve been so unhappy I’ve had difficulty sleeping”. We explored maternal anxiety symptoms (Wisner et al, 2013) with the SIGH-ADS items for anxiety: agitation, psychic anxiety, somatic symptoms, hypochondriasis and obsessive thoughts or compulsive behaviors (items H17, H12, H13, H14, and H21), and a composite 7-point anxiety subscale (Clark et al, 2001; Fawcett et al, 1990; Moritz et al, 2004) comprised of the SIGH-ADS anxiety items plus EPDS items 4 and 5, “I’ve been anxious or worried for no good reason and “I’ve felt scared or panicky for no very good reason”.…”

Section: Methodsmentioning

confidence: 99%

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Suicidal ideation in depressed postpartum women: Associations with childhood trauma, sleep disturbance and anxiety

Sit

Luther

Buysse

et al. 2015

Journal of Psychiatric Research

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Background Suicide is one of the leading causes of death in postpartum women. Identifying modifiable factors related to suicide risk in mothers after delivery is a public health priority. Our study aim was to examine associations between suicidal ideation (SI) and plausible risk factors (experience of abuse in childhood or as an adult, sleep disturbance, and anxiety symptoms) in depressed postpartum women. Methods This secondary analysis included 628 depressed mothers at 4–6 weeks postpartum. Diagnosis was confirmed with the Structured Clinical Interview for DSM-IV. We examined SI from responses to the Edinburgh Postnatal Depression Scale-EPDS item 10; depression levels on the Structured Interview Guide for the Hamilton Depression Rating Scale, Atypical Depression Symptoms (SIGH-ADS); plus sleep disturbance and anxiety levels with subscales from the EPDS and SIGH-ADS items on sleep and anxiety symptoms.. Results Of the depressed mothers, 496 (79%) ‘never’ had thoughts of self-harm; 98 (15.6%) ‘hardly ever’; and 34 (5.4%) ‘sometimes’ or ‘quite often’. Logistic regression models indicated that having frequent thoughts of self-harm was related to childhood physical abuse (odds ratio-OR=1.68, 95% CI=1.00, 2.81); in mothers without childhood physical abuse, having frequent self-harm thoughts was related to sleep disturbance (OR=1.15, 95%CI=1.02, 1.29) and anxiety symptoms (OR=1.11, 95%CI=1.01, 1.23). Discussion Because women with postpartum depression can present with frequent thoughts of self-harm and a high level of clinical complexity, conducting a detailed safety assessment, that includes evaluation of childhood abuse history and current symptoms of sleep disturbance and anxiety, is a key component in the management of depressed mothers.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Suicidal ideation in depressed postpartum women: Associations with childhood trauma, sleep disturbance and anxiety

Sit

Luther

Buysse

et al. 2015

Journal of Psychiatric Research

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“…The assessment at age 25 included 528 (75%) of the initial 709 participants. Details about recruitment procedures and attrition analyses have been published in prior publications (e.g., Clark, Lynch, Donovan, & Block, 2001; Clark, Thatcher, & Martin, 2010). Participants who missed the young-adult assessment, compared with those who completed the visit, were more likely to be male, were older at baseline, were more likely to be African American, had a lower socioeconomic status (SES), were less likely to have been recruited from the community, and were more likely to have adolescent AUDs.…”

Section: Methodsmentioning

confidence: 99%

Solitary Alcohol Use in Teens Is Associated With Drinking in Response to Negative Affect and Predicts Alcohol Problems in Young Adulthood

Creswell

Chung

Clark

et al. 2013

Clinical Psychological Science

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Adolescent solitary drinking may represent an informative divergence from normative behavior, with important implications for understanding risk for alcohol-use disorders later in life. Within a self-medication framework, we hypothesized that solitary alcohol use would be associated with drinking in response to negative affect and that such a pattern of drinking would predict alcohol problems in young adulthood. We tested these predictions in a longitudinal study in which we examined whether solitary drinking in adolescence (ages 12–18) predicted alcohol-use disorders in young adulthood (age 25) in 466 alcohol-using teens recruited from clinical programs and 243 alcohol-using teens recruited from the community. Findings showed that solitary drinking was associated with drinking in response to negative affect during adolescence and predicted alcohol problems in young adulthood. Results indicate that drinking alone is an important type of alcohol-use behavior that increases risk for the escalation of alcohol use and the development of alcohol problems.

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“…In 703 South African adolescents, overall sleep problems (trouble falling or staying sleep, tiredness in the morning, and/or daytime sleepiness) were associated with greater lifetime alcohol and drug use, and this association was independent of the effect of learning difficulties (Fakier & Wild, 2011). Comparing adolescents with AUDs and a reference group, Clark and colleagues (Clark, Lynch, Donovan, & Block, 2001) found self-reported sleep problems (5 items) to be significantly associated with AUD, negative emotionality, and tobacco involvement. The association between AUD and sleep problems remained statistically significant after controlling for negative emotionality and tobacco involvement.…”

Section: Cross-sectional Associations Between Sleep Circadian Rhythmmentioning

confidence: 99%

Sleep and circadian contributions to adolescent alcohol use disorder

Hasler

Soehner

Clark

2015

Alcohol

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Adolescence is a time of marked changes across sleep, circadian rhythms, brain function, and alcohol use. Starting at puberty, adolescents’ endogenous circadian rhythms and preferred sleep times shift later, often leading to a mismatch with the schedules imposed by secondary education. This mismatch induces circadian misalignment and sleep loss, which have been associated with affect dysregulation, increased drug and alcohol use, and other risk-taking behaviors in adolescents and adults. In parallel to developmental changes in sleep, adolescent brains are undergoing structural and functional changes in the circuits subserving the pursuit and processing of rewards. These developmental changes in reward processing likely contribute to the initiation of alcohol use during adolescence. Abundant evidence indicates that sleep and circadian rhythms modulate reward function, suggesting that adolescent sleep and circadian disturbance may contribute to altered reward function, and in turn, alcohol involvement. In this review, we summarize the relevant evidence and propose that these parallel developmental changes in sleep, circadian rhythms, and neural processing of reward interact to increase risk for alcohol use disorder (AUD).

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Health Problems in Adolescents With Alcohol Use Disorders: Self-Report, Liver Injury, and Physical Examination Findings and Correlates

Abstract: These results indicated that AUDs during adolescence were associated with health problems, including modest but demonstrable liver injury. Self-reported health problems were probably best understood, in this context, as a negative emotionality manifestation.

Cited by 16 publications

References 54 publications

Suicidal ideation in depressed postpartum women: Associations with childhood trauma, sleep disturbance and anxiety

Suicidal ideation in depressed postpartum women: Associations with childhood trauma, sleep disturbance and anxiety

Solitary Alcohol Use in Teens Is Associated With Drinking in Response to Negative Affect and Predicts Alcohol Problems in Young Adulthood

Sleep and circadian contributions to adolescent alcohol use disorder

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